Search Results - "Simpson, Peter J"

Specific DNA recognition mediated by a type IV pilin by Cehovin, Ana, Simpson, Peter J., McDowell, Melanie A., Brown, Daniel R., Noschese, Rossella, Pallett, Mitchell, Brady, Jacob, Baldwin, Geoffrey S., Lea, Susan M., Matthews, Stephen J., Pelicic, Vladimir

“…Natural transformation is a dominant force in bacterial evolution by promoting horizontal gene transfer. This process may have devastating consequences, such…”
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Ion Beam Modification for Si Photonics by Goncharova, Lyudmila V., Simpson, Peter J.

“…Ion implantation has played a significant role in semiconductor device fabrication and is growing in significance in the fabrication of Si photonic devices. In…”
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Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans by Salgado, Paula S., Yan, Robert, Taylor, Jonathan D., Burchell, Lynn, Jones, Rhian, Hoyer, Lois L., Matthews, Steve J., Simpson, Peter J., Cota, Ernesto

“…Candida albicans is the most prevalent fungal pathogen in humans and a major source of life-threatening nosocomial infections. The Ais (a̲gglutinin-l̲ike…”
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A New Labeling Method for Methyl Transverse Relaxation-Optimized Spectroscopy NMR Spectra of Alanine Residues by Isaacson, Rivka L, Simpson, Peter J, Liu, Minhao, Cota, Ernesto, Zhang, Xiaodong, Freemont, Paul, Matthews, Stephen

“…The development of specific methyl labeling schemes and transverse relaxation-optimized spectroscopy (TROSY) has extended the molecular size range for the…”
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Atomic Resolution Insights into Curli Fiber Biogenesis by Taylor, Jonathan D., Zhou, Yizhou, Salgado, Paula S., Patwardhan, Ardan, McGuffie, Matt, Pape, Tillmann, Grabe, Grzegorz, Ashman, Elisabeth, Constable, Sean C., Simpson, Peter J., Lee, Wei-chao, Cota, Ernesto, Chapman, Matthew R., Matthews, Steve J.

“…Bacteria produce functional amyloid fibers called curli in a controlled, noncytotoxic manner. These extracellular fimbriae enable biofilm formation and promote…”
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Enzymatic activities and functional interdependencies of Bacillus subtilis lipoteichoic acid synthesis enzymes by Wörmann, Mirka E., Corrigan, Rebecca M., Simpson, Peter J., Matthews, Steve J., Gründling, Angelika

“…Summary Lipoteichoic acid (LTA) is an important cell wall polymer in Gram‐positive bacteria. The enzyme responsible for polyglycerolphosphate LTA synthesis is…”
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Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus by Garnett, James A, Martínez-Santos, Verónica I, Saldaña, Zeus, Pape, Tillmann, Hawthorne, William, Chan, Jennifer, Simpson, Peter J, Cota, Ernesto, Puente, José L, Girón, Jorge A, Matthews, Steve

“…Bacteria have evolved a variety of mechanisms for developing community-based biofilms. These bacterial aggregates are of clinical importance, as they are a…”
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Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing by Joshi, Amar, Coelho, Miguel B., Kotik-Kogan, Olga, Simpson, Peter J., Matthews, Stephen J., Smith, Christopher W.J., Curry, Stephen

“…The polypyrimidine tract-binding protein (PTB) is an important regulator of alternative splicing. PTB-regulated splicing of α-tropomyosin is enhanced by…”
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Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins by Simon, Aline C., Simpson, Peter J., Goldstone, Rachael M., Krysztofinska, Ewelina M., Murray, James W., High, Stephen, Isaacson, Rivka L.

“…Small, glutamine-rich, tetratricopeptide repeat protein 2 (Sgt2) is the first known port of call for many newly synthesized tail-anchored (TA) proteins…”
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The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex by Bergeron, Julien R C, Huthoff, Hendrik, Veselkov, Dennis A, Beavil, Rebecca L, Simpson, Peter J, Matthews, Stephen J, Malim, Michael H, Sanderson, Mark R

“…The HIV-1 viral infectivity factor (Vif) protein recruits an E3 ubiquitin ligase complex, comprising the cellular proteins elongin B and C (EloBC), cullin 5…”
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Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A by Darby, John F, Krysztofinska, Ewelina M, Simpson, Peter J, Simon, Aline C, Leznicki, Pawel, Sriskandarajah, Newran, Bishop, David S, Hale, Lisa R, Alfano, Caterina, Conte, Maria R, Martínez-Lumbreras, Santiago, Thapaliya, Arjun, High, Stephen, Isaacson, Rivka L

“…The BAG6 complex resides in the cytosol and acts as a sorting point to target diverse hydrophobic protein substrates along their appropriate paths, including…”
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Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins by Leen, Eoin N, Kwok, K Y Rex, Birtley, James R, Simpson, Peter J, Subba-Reddy, Chennareddy V, Chaudhry, Yasmin, Sosnovtsev, Stanislav V, Green, Kim Y, Prater, Sean N, Tong, Michael, Young, Joanna C, Chung, Liliane M W, Marchant, Jan, Roberts, Lisa O, Kao, C Cheng, Matthews, Stephen, Goodfellow, Ian G, Curry, Stephen

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting by Simpson, Peter J., Schwappach, Blanche, Dohlman, Henrik G., Isaacson, Rivka L.

“…The GET pathway, using several proteins (Gets 1-5 and probably Sgt2), posttranslationally conducts tail-anchored (TA) proteins to the endoplasmic reticulum…”
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Automated Assignment in Selectively Methyl-Labeled Proteins by Xu, Yingqi, Liu, Minhao, Simpson, Peter J, Isaacson, Rivka, Cota, Ernesto, Marchant, Jan, Yang, Daiwen, Zhang, Xiaodong, Freemont, Paul, Matthews, Stephen

“…Specific methyl labeling schemes and transverse relaxation optimized spectroscopy (TROSY) has extended the molecular size range for the application of NMR…”
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Structure and RNA Interactions of the N-Terminal RRM Domains of PTB by Simpson, Peter J., Monie, Tom P., Szendröi, Andrea, Davydova, Natalia, Tyzack, Jonathan K., Conte, Maria R., Read, Christopher M., Cary, Peter D., Svergun, Dmitri I., Konarev, Peter V., Curry, Stephen, Matthews, Stephen

“…The polypyrimidine tract binding protein (PTB) is an important regulator of alternative splicing that also affects mRNA localization, stabilization,…”
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Surface Debye temperature determination from LEED: correlation to defects in epitaxial films by Adam, Matheus C., Darukhanawalla, Nazban, Gaudet, James M., O’Hara, Guenevere, Harford, Paige, Hall, Greg, Ociepa, Jozef, Weber, Marc H., Simpson, Peter J., Goncharova, Lyudmila V.

“…•Surface Debye T depends on defect density in the surface and near-surface layers.•Larger defect concentration results in lower surface Debye temperature.•LEED…”
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Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches by Darby, John F., Vidler, Lewis R., Simpson, Peter J., Al-Lazikani, Bissan, Matthews, Stephen J., Sharp, Swee Y., Pearl, Laurence H., Hoelder, Swen, Workman, Paul

“…Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an important role in tumour biology by promoting the stabilisation and activity of oncogenic…”
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Solution Structure of the CBM10 Cellulose Binding Module from Pseudomonas Xylanase A by Raghothama, S, Simpson, Peter J, Szabó, Lóránd, Nagy, Tibor, Gilbert, Harry J, Williamson, Michael P

“…Plant cell wall hydrolases generally have a modular structure consisting of a catalytic domain linked to one or more noncatalytic carbohydrate-binding modules…”
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The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase by Tabib-Salazar, Aline, Liu, Bing, Doughty, Philip, Lewis, Richard A, Ghosh, Somadri, Parsy, Marie-Laure, Simpson, Peter J, O'Dwyer, Kathleen, Matthews, Steve J, Paget, Mark S

“…RbpA is a small non-DNA-binding transcription factor that associates with RNA polymerase holoenzyme and stimulates transcription in actinobacteria, including…”
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A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity by Simpson, Peter J, Bolam, David N, Cooper, Alan, Ciruela, Antonio, Hazlewood, Geoffrey P, Gilbert, Harry J, Williamson, Michael P

“…Background: Many enzymes that digest polysaccharides contain separate polysaccharide-binding domains. Structures have been previously determined for a number…”
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