Search Results - "Simpson, Norman R"

Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635 by PARSEY, Ramin V, OQUENDO, Maria A, SIMPSON, Norman R, OGDEN, R. Todd, VAN HEERTUM, Ronald, ARANGO, Victoria, MANN, J. John

“…Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain…”
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Synthesis and in vivo evaluation of [ 18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression by Prabhakaran, Jaya, Underwood, Mark D., Parsey, Ramin V., Arango, Victoria, Majo, Vattoly J., Simpson, Norman R., Van Heertum, Ronald, Mann, J. John, Kumar, J.S. Dileep

“…Synthesis of [ 18F]4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide ([ 18F]celecoxib), a selective COX-2 inhibitor, is achieved via…”
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Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide by Youssef, Mariam M, Underwood, Mark D, Huang, Yung-Yu, Hsiung, Shu-Chi, Liu, Yan, Simpson, Norman R, Bakalian, Mihran J, Rosoklija, Gorazd B, Dwork, Andrew J, Arango, Victoria, Mann, J John

“…Brain-derived neurotrophic factor is implicated in the pathophysiology of major depressive disorder and suicide. Both are partly caused by early life…”
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Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates by Kumar, J S Dileep, Prabhakaran, Jaya, Majo, Vattoly J, Milak, Matthew S, Hsiung, Shu-Chi, Tamir, Hadassah, Simpson, Norman R, Van Heertum, Ronald L, Mann, J John, Parsey, Ramin V

“…Serotonin1A (5-HT1A) receptors exist in high- and low-affinity states, and agonist ligands bind preferentially to the high-affinity state of the receptor and…”
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A general method for the synthesis of aryl [ 11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression by Majo, Vattoly J., Prabhakaran, Jaya, Simpson, Norman R., Van Heertum, Ronald L., Mann, J. John, Dileep Kumar, J.S.

“…A general one-pot method has been developed for the conversion of an aryl thiol moiety masked as the butyrate ester to the corresponding 11C-labeled…”
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A Stress Protein–Based Suicide Prediction Score and Relationship to Reported Early-Life Adversity and Recent Life Stress by Underwood, Mark D, Galfalvy, Hanga, Hsiung, Shu-chi, Liu, Yan, Simpson, Norman R, Bakalian, Mihran J, Rosoklija, Gorazd B, Dwork, Andrew J, Arango, Victoria, Mann, J John

“…Abstract Background The hypothalamic-pituitary-adrenal (HPA) axis is a major stress response system, and excessive HPA responses can impact major depressive…”
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Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors by DILEEP KUMAR, J. S, MAJO, Vattoly J, SULLIVAN, Gregory M, PRABHAKARAN, Jaya, SIMPSON, Norman R, VAN HEERTUM, Ronald L, MANN, J. John, PARSEY, Ramin V

“…Synthesis and evaluation of [O-methyl-11C](4-methoxy-2-methylphenyl)[1-(1-methoxymethylpropyl)-6-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-4-yl]amine or…”
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Radiosynthesis and in vivo evaluation of [11C]MOV as a PET imaging agent for COX-2 by Prabhakaran, Jaya, Underwood, Mark, Zanderigo, Francesca, Simpson, Norman R., Cooper, Anna R., Matthew, Jeffrey, Rubin-Falcone, Harry, Parsey, Ramin V., Mann, J. John, Dileep Kumar, J.S.

“…[Display omitted] •Induced COX-2 expression is one of the pathophysiology of inflammation.•Upregulation of COX-2 expression is a biomarker for…”
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Synthesis of [11C]celecoxib: a potential PET probe for imaging COX-2 expression by Prabhakaran, Jaya, Majo, Vattoly J., Simpson, Norman R., Van Heertum, Ronald L., Mann, J. John, Kumar, J. S. Dileep

“…[11C]Labeling of celecoxib, a COX‐2 selective inhibitor and prescription drug for arthritis and pain has been achieved. The precursor molecule for the…”
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In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter by Severance, Alin J, Milak, Matthew S, Kumar, J S Dileep, Prabhakaran, Jaya, Majo, Vattoly J, Simpson, Norman R, Van Heertum, Ronald L, Arango, Victoria, Mann, J John, Parsey, Ramin V

“…Antagonism of norepinephrine reuptake is now an important pharmacological strategy in the treatment of anxiety and depressive disorders, and many…”
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Synthesis and in vitro evaluation of [18F]FECIMBI-36: A potential agonist PET ligand for 5-HT2A/2C receptors by Prabhakaran, Jaya, Underwood, Mark D., Kumar, J.S. Dileep, Simpson, Norman R., Kassir, Suham A., Bakalian, Mihran J., Mann, J. John, Arango, Victoria

“…[Display omitted] Radiosynthesis and in vitro evaluation of [18F]-2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-(2-fluoroethoxy)benzyl)ethanamine, ([18F]FECIMBI-36) or…”
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In vivo evaluation of IGF1R/IR PET ligand [18F]BMS-754807 in rodents by Prabhakaran, Jaya, Dewey, Stephen L., McClure, Richard, Simpson, Norman R., Tantawy, Mohammed N., Mann, J. John, Pham, Wellington, Kumar, J.S. Dileep

“…[Display omitted] In vivo evaluation of [18F]BMS-754807 binding in mice and rats using microPET and biodistribution methods is described herein. The…”
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Synthesis and in vivo evaluation of [18F]2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione ([18F]FECUMI-101) as an imaging probe for 5-HT1A receptor agonist in nonhuman primates by Majo, Vattoly J., Milak, Matthew S., Prabhakaran, Jaya, Mali, Pratap, Savenkova, Lyudmila, Simpson, Norman R., Mann, J. John, Parsey, Ramin V., Kumar, J. S. Dileep

“…The 5-HT1AR partial agonist PET radiotracer, [11C]CUMI-101, has advantages over an antagonist radiotracer as it binds preferentially to the high affinity state…”
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Synthesis of [O-methyl-11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB1 receptors by Kumar, J S Dileep, Prabhakaran, Jaya, Arango, Victoria, Parsey, Ramin V, Underwood, Mark D, Simpson, Norman R, Kassir, Suham A, Majo, Vattoly J, Van Heertum, Ronald L, Mann, J John

“…Synthesis and in vitro evaluation of [O-methyl-(11)C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide…”
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Synthesis and in vitro evaluation of [18F]BMS-754807: A potential PET ligand for IGF-1R by Majo, Vattoly J., Arango, Victoria, Simpson, Norman R., Prabhakaran, Jaya, Kassir, Suham A., Underwood, Mark D., Bakalian, Mihran, Canoll, Peter, John Mann, J., Dileep Kumar, J.S.

“…Radiosynthesis and in vitro evaluation of…”
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Autoradiographic evaluation of [3H]CUMI-101, a novel, selective 5-HT1AR ligand in human and baboon brain by Kumar, J.S. Dileep, Parsey, Ramin V., Kassir, Suham A., Majo, Vattoly J., Milak, Matthew S., Prabhakaran, Jaya, Simpson, Norman R., Underwood, Mark D., Mann, J. John, Arango, Victoria

“…[11C]CUMI-101 is the first selective serotonin receptor (5-HT1AR) partial agonist radiotracer for positron emission tomography (PET) tested in vivo in nonhuman…”
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Autoradiographic Evaluation of [18F]FECUMI-101, a High Affinity 5‑HT1AR Ligand in Human Brain by Kumar, J. S. Dileep, Underwood, Mark D, Simpson, Norman R, Kassir, Suham A, Prabhakaran, Jaya, Majo, Vattoly J, Bakalian, Mihran J, Parsey, Ramin V, Mann, J. John, Arango, Victoria

“…[18F]­FECUMI-101 ([18F]1) is a 5HT1AR ligand demonstrating specific binding in brain regions corresponding to the distribution of 5-HT1AR in baboons. However,…”
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Radiosynthesis of [18F]ATPFU: a potential PET ligand for mTOR by Majo, Vattoly J., Simpson, Norman R., Prabhakaran, Jaya, Mann, J. John, Kumar, J. S. Dileep

“…Mammalian target of rapamycin (mTOR) plays a pivotal role in many aspects of cellular proliferation, and recent evidence suggests that an altered mTOR…”
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Synthesis and in Vivo Validation of [O-Methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione:  A Novel 5-HT1A Receptor Agonist Positron Emission Tomography Ligand by Kumar, J. S. Dileep, Majo, Vattoly J, Hsiung, Shu-Chi, Millak, Matthew S, Liu, Kuo-Peing, Tamir, Hadassah, Prabhakaran, Jaya, Simpson, Norman R, Van Heertum, Ronald L, Mann, J. John, Parsey, Ramin V

“…Antagonist 5-HT1A PET ligands are available, but an agonist ligand would give more information about signal transduction capacity. Synthesis and in vivo…”
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Synthesis and in vitro evaluation of [18F](R)-FEPAQ: A potential PET ligand for VEGFR2 by Prabhakaran, Jaya, Arango, Victoria, Majo, Vattoly J., Simpson, Norman R., Kassir, Suham A., Underwood, Mark D., Polavarapu, Hanish, Bruce, Jeffrey N., Canoll, Peter, John Mann, J., Dileep Kumar, J.S.

“…Synthesis and in vitro evaluation of [18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine…”
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