Search Results - "Simpson, Laura W"

Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues by Simpson, Laura W., Good, Theresa A., Leach, Jennie B.

“…In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded,…”
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Impact of Four Common Hydrogels on Amyloid‑β (Aβ) Aggregation and Cytotoxicity: Implications for 3D Models of Alzheimer’s Disease by Simpson, Laura W, Szeto, Gregory L, Boukari, Hacene, Good, Theresa A, Leach, Jennie B

“…The physiochemical properties of hydrogels utilized in 3D culture can be used to modulate cell phenotype and morphology with a striking resemblance to cellular…”
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Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects by Simpson, Laura W., Szeto, Gregory L., Boukari, Hacene, Good, Theresa A., Leach, Jennie B.

“…Alzheimer's disease (AD) is the most common form of dementia and is associated with the accumulation of amyloid-β (Aβ), a peptide whose aggregation has been…”
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Direct, Real-Time Detection of Adenosine Triphosphate Release from Astrocytes in Three-Dimensional Culture Using an Integrated Electrochemical Aptamer-Based Sensor by Santos-Cancel, Mirelis, Simpson, Laura W, Leach, Jennie B, White, Ryan J

“…In this manuscript, we describe the development and application of electrochemical aptamer-based (E-AB) sensors directly interfaced with astrocytes in…”
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Bioengineered Models of Alzheimer's Disease: Studying Amyloid Beta (αβ) Protein Aggregation within 3D Scaffolds by Simpson, Laura W

“…Alzheimer’s disease (AD) is the most common form of dementia and is associated with the accumulation of amyloid-β (Aβ), a peptide that can aggregate into…”
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Direct, Real-Time Detection of Adenosine Triphosphate Release from Astrocytes in 3-Dimensional Culture Using an Integrated Electrochemical, Aptamer-Based Sensor by Santos-Cancel, Mirelis, Simpson, Laura W., Leach, Jennie B., White, Ryan J.

“…In this manuscript, we describe the development and application of electrochemical, aptamer-based (E-AB) sensors directly interfaced with astrocytes in…”
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