Search Results - "Simpson, Kenneth W"

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota by Arthur, Janelle C., Perez-Chanona, Ernesto, Mühlbauer, Marcus, Tomkovich, Sarah, Uronis, Joshua M., Fan, Ting-Jia, Campbell, Barry J., Abujamel, Turki, Dogan, Belgin, Rogers, Arlin B., Rhodes, Jonathan M., Stintzi, Alain, Simpson, Kenneth W., Hansen, Jonathan J., Keku, Temitope O., Fodor, Anthony A., Jobin, Christian

“…Inflammation alters host physiology to promote cancer, as seen in colitis-associated colorectal cancer (CRC). Here, we identify the intestinal microbiota as a…”
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Complex disease and phenotype mapping in the domestic dog by Hayward, Jessica J., Castelhano, Marta G., Oliveira, Kyle C., Corey, Elizabeth, Balkman, Cheryl, Baxter, Tara L., Casal, Margret L., Center, Sharon A., Fang, Meiying, Garrison, Susan J., Kalla, Sara E., Korniliev, Pavel, Kotlikoff, Michael I., Moise, N. S., Shannon, Laura M., Simpson, Kenneth W., Sutter, Nathan B., Todhunter, Rory J., Boyko, Adam R.

“…The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and…”
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Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation by Viladomiu, Monica, Metz, Maeva L., Lima, Svetlana F., Jin, Wen-Bing, Chou, Lance, Guo, Chun-Jun, Diehl, Gretchen E., Simpson, Kenneth W., Scherl, Ellen J., Longman, Randy S.

“…Adherent-invasive E. coli (AIEC) are enriched in the intestinal microbiota of patients with Crohn’s disease (CD) and promote intestinal inflammation. Yet, how…”
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Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease by Craven, Melanie, Egan, Charlotte E, Dowd, Scot E, McDonough, Sean P, Dogan, Belgin, Denkers, Eric Y, Bowman, Dwight, Scherl, Ellen J, Simpson, Kenneth W

“…Understanding the interplay between genetic susceptibility, the microbiome, the environment and the immune system in Crohn's Disease (CD) is essential for…”
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Specific Strains of Escherichia coli Are Pathogenic for the Endometrium of Cattle and Cause Pelvic Inflammatory Disease in Cattle and Mice by Sheldon, I. Martin, Rycroft, Andrew N, Dogan, Belgin, Craven, Melanie, Bromfield, John J, Chandler, Alyssa, Roberts, Mark H, Price, Sian B, Gilbert, Robert O, Simpson, Kenneth W

“…Background: Escherichia coli are widespread in the environment and pathogenic strains cause diseases of mucosal surfaces including the female genital tract…”
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Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival by Sun, Shengyi, Shi, Guojun, Han, Xuemei, Francisco, Adam B., Ji, Yewei, Mendonça, Nuno, Liu, Xiaojing, Locasale, Jason W., Simpson, Kenneth W., Duhamel, Gerald E., Kersten, Sander, Yates, John R., Long, Qiaoming, Qi, Ling

“…Suppressor/Enhancer of Lin-12-like (Sel1L) is an adaptor protein for the E3 ligase hydroxymethylglutaryl reductase degradation protein 1 (Hrd1) involved in…”
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Escherichia coli‐associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling by Manchester, Alison C., Dogan, Belgin, Guo, Yongli, Simpson, Kenneth W.

“…Background Eradication of intramucosal Escherichia coli correlates with remission of periodic acid‐Schiff‐positive E coli‐associated granulomatous colitis…”
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Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease by Simpson, Kenneth W, Jergens, Albert E

“…Inflammatory bowel disease (IBD) is the collective term for a group of chronic enteropathies characterized by persistent or recurrent gastrointestinal (GI)…”
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Long-read sequencing to interrogate strain-level variation among adherent-invasive Escherichia coli isolated from human intestinal tissue by Wang, Jeremy, Bleich, Rachel M, Zarmer, Sandra, Zhang, Shiying, Dogan, Belgin, Simpson, Kenneth W, Arthur, Janelle C

“…Adherent-invasive Escherichia coli (AIEC) is a pathovar linked to inflammatory bowel diseases (IBD), especially Crohn's disease, and colorectal cancer. AIEC…”
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Inflammation-associated adherent-invasive Escherichia coli are enriched in pathways for use of propanediol and iron and M-cell translocation by Dogan, Belgin, Suzuki, Haruo, Herlekar, Deepali, Sartor, R Balfour, Campbell, Barry J, Roberts, Carol L, Stewart, Katrina, Scherl, Ellen J, Araz, Yasemin, Bitar, Paulina P, Lefébure, Tristan, Chandler, Brendan, Schukken, Ynte H, Stanhope, Michael J, Simpson, Kenneth W

“…Perturbations of the intestinal microbiome, termed dysbiosis, are linked to intestinal inflammation. Isolation of adherent-invasive Escherichia coli (AIEC)…”
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A high-throughput integrated biofilm-on-a-chip platform for the investigation of combinatory physicochemical responses to chemical and fluid shear stress by Nguyen, Ann V, Shourabi, Arash Yahyazadeh, Yaghoobi, Mohammad, Zhang, Shiying, Simpson, Kenneth W, Abbaspourrad, Alireza

“…Physicochemical conditions play a key role in the development of biofilm removal strategies. This study presents an integrated, double-layer, high-throughput…”
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Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum by Baumgart, Martin, Dogan, Belgin, Rishniw, Mark, Weitzman, Gil, Bosworth, Brian, Yantiss, Rhonda, Orsi, Renato H, Wiedmann, Martin, McDonough, Patrick, Kim, Sung Guk, Berg, Douglas, Schukken, Ynte, Scherl, Ellen, Simpson, Kenneth W

“…Intestinal bacteria are implicated increasingly as a pivotal factor in the development of Crohn's disease, but the specific components of the complex…”
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Randomized controlled trial of hydrolyzed fish diets in dogs with chronic enteropathy by Simpson, Kenneth W., Miller, Meredith L., Loftus, John P., Rishniw, Mark, Frederick, Carol E., Wakshlag, Joseph J.

“…Background The role of diet in the pathogenesis and treatment of chronic enteropathies (CE) in dogs is unresolved. Objectives To compare the ability of diets…”
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Short Chain Fatty Acids Modulate the Growth and Virulence of Pathosymbiont Escherichia coli and Host Response by Zhang, Shiying, Dogan, Belgin, Guo, Cindy, Herlekar, Deepali, Stewart, Katrina, Scherl, Ellen J., Simpson, Kenneth W.

“…Short chain fatty acids (SCFA), principally acetate, propionate, and butyrate, are produced by fermentation of dietary fibers by the gut microbiota. SCFA…”
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Genome-wide association studies of inflammatory bowel disease in German shepherd dogs by Peiravan, Atiyeh, Bertolini, Francesca, Rothschild, Max F, Simpson, Kenneth W, Jergens, Albert E, Allenspach, Karin, Werling, Dirk

“…Canine Inflammatory Bowel Disease (IBD) is considered a multifactorial disease caused by complex interactions between the intestinal immune system, intestinal…”
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5-Aminosalicylic acid downregulates the growth and virulence of Escherichia coli associated with IBD and colorectal cancer, and upregulates host anti-inflammatory activity by Zhang, Shiying, Fu, Jing, Dogan, Belgin, Scherl, Ellen J., Simpson, Kenneth W.

“…5-aminosalicylate (5-ASA) is widely prescribed for the treatment of inflammatory bowel disease (IBD) and prevention of inflammation-associated colorectal…”
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Imputation of canine genotype array data using 365 whole-genome sequences improves power of genome-wide association studies by Hayward, Jessica J, White, Michelle E, Boyle, Michael, Shannon, Laura M, Casal, Margret L, Castelhano, Marta G, Center, Sharon A, Meyers-Wallen, Vicki N, Simpson, Kenneth W, Sutter, Nathan B, Todhunter, Rory J, Boyko, Adam R

“…Genomic resources for the domestic dog have improved with the widespread adoption of a 173k SNP array platform and updated reference genome. SNP arrays of this…”
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Dietary l-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut by Kitamoto, Sho, Alteri, Christopher J., Rodrigues, Michael, Nagao-Kitamoto, Hiroko, Sugihara, Kohei, Himpsl, Stephanie D., Bazzi, Malak, Miyoshi, Mao, Nishioka, Tatsuki, Hayashi, Atsushi, Morhardt, Tina L., Kuffa, Peter, Grasberger, Helmut, El-Zaatari, Mohamad, Bishu, Shrinivas, Ishii, Chiharu, Hirayama, Akiyoshi, Eaton, Kathryn A., Dogan, Belgin, Simpson, Kenneth W., Inohara, Naohiro, Mobley, Harry L. T., Kao, John Y., Fukuda, Shinji, Barnich, Nicolas, Kamada, Nobuhiko

“…Metabolic reprogramming is associated with the adaptation of host cells to the disease environment, such as inflammation and cancer. However, little is known…”
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Rifaximin decreases virulence of Crohn’s disease-associated Escherichia coli and epithelial inflammatory responses by Dogan, Belgin, Fu, Jing, Zhang, Shiying, Scherl, Ellen J., Simpson, Kenneth W.

“…Escherichia coli with an adherent and invasive pathotype (AIEC) is implicated in the pathogenesis of Crohn’s disease (CD). Rifaximin improves symptoms in…”
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Rifaximin Resistance in Escherichia coli Associated with Inflammatory Bowel Disease Correlates with Prior Rifaximin Use, Mutations in rpoB, and Activity of Phe-Arg-β-Naphthylamide-Inhibitable Efflux Pumps by KOTHARY, Vishesh, SCHERL, Ellen J, BOSWORTH, Brian, JIANG, Zhi-Dong, DUPONT, Herbert L, HAREL, Josee, SIMPSON, Kenneth W, DOGAN, Belgin

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