Search Results - "Simpson, Karen D."

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients by Michalovich, David, Rodriguez-Perez, Noelia, Smolinska, Sylwia, Pirozynski, Michal, Mayhew, David, Uddin, Sorif, Van Horn, Stephanie, Sokolowska, Milena, Altunbulakli, Can, Eljaszewicz, Andrzej, Pugin, Benoit, Barcik, Weronika, Kurnik-Lucka, Magdalena, Saunders, Ken A., Simpson, Karen D., Schmid-Grendelmeier, Peter, Ferstl, Ruth, Frei, Remo, Sievi, Noriane, Kohler, Malcolm, Gajdanowicz, Pawel, Graversen, Katrine B., Lindholm Bøgh, Katrine, Jutel, Marek, Brown, James R., Akdis, Cezmi A., Hessel, Edith M., O’Mahony, Liam

“…In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease…”
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nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines by Gibbs, Julie E, Blaikley, John, Beesley, Stephen, Matthews, Laura, Simpson, Karen D, Boyce, Susan H, Farrow, Stuart N, Else, Kathryn J, Singh, Dave, Ray, David W, Loudon, Andrew S. I

“…Diurnal variation in inflammatory and immune function is evident in the physiology and pathology of humans and animals, but molecular mechanisms and mediating…”
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Obesity dysregulates the pulmonary antiviral immune response by Almond, Mark, Farne, Hugo A., Jackson, Millie M., Jha, Akhilesh, Katsoulis, Orestis, Pitts, Oliver, Tunstall, Tanushree, Regis, Eteri, Dunning, Jake, Byrne, Adam J., Mallia, Patrick, Kon, Onn Min, Saunders, Ken A., Simpson, Karen D., Snelgrove, Robert J., Openshaw, Peter J. M., Edwards, Michael R., Barclay, Wendy S., Heaney, Liam M., Johnston, Sebastian L., Singanayagam, Aran

“…Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms underlying susceptibility are poorly understood. Here, we identify…”
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The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD by Russell, Kirsty E, Chung, Kian Fan, Clarke, Colin J, Durham, Andrew L, Mallia, Patrick, Footitt, Joseph, Johnston, Sebastian L, Barnes, Peter J, Hall, Simon R, Simpson, Karen D, Starkey, Malcolm R, Hansbro, Philip M, Adcock, Ian M, Wiegman, Coen H

“…Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with acute and chronic inflammatory disorders and corticosteroid…”
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Increased Nerve Fiber Expression of Sensory Sodium Channels Nav1.7, Nav1.8, and Nav1.9 in Rhinitis by Keh, Siew M., Facer, Paul, Simpson, Karen D., Sandhu, Guri, Saleh, Hesham A., Anand, Praveen

“…Introduction: Voltage‐gated sodium channels Nav1.7, Nav1.8, and Nav1.9 are involved in nerve action potentials and have been proposed to underlie neuronal…”
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The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages by Lea, Simon R, Reynolds, Sophie L, Kaur, Manminder, Simpson, Karen D, Hall, Simon R, Hessel, Edith M, Singh, Dave

“…COPD is a progressive inflammatory airway disease characterized by increased numbers of alveolar macrophages in the lungs. Bacterial colonization of the lungs…”
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Neuronal Markers in Allergic Rhinitis: Expression and Correlation With Sensory Testing by O'Hanlon, Stephen, Facer, Paul, Simpson, Karen D., Sandhu, Guri, Saleh, Hesham A., Anand, Praveen

“…Introduction: Although the role of immunoglobulin E‐mediated hypersensitivity reactions in allergic rhinitis is well known, the relative contribution of…”
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A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function by Trebble, Peter J, Woolven, James M, Saunders, Ken A, Simpson, Karen D, Farrow, Stuart N, Matthews, Laura C, Ray, David W

“…The ubiquitously expressed glucocorticoid receptor (GR) is a major drug target for inflammatory disease, but issues of specificity and target tissue…”
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Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK by Maddi, Satyanarayana, Kolsum, Umme, Jackson, Sarah, Barraclough, Richard, Maschera, Barbara, Simpson, Karen D, Pascal, Thierry G, Durviaux, Serge, Hessel, Edith M, Singh, Dave

“…is commonly isolated from the airways of COPD patients. Antibiotic treatment may cause the emergence of resistant strains, particularly ampicillin-resistant…”
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The nuclear receptor REV-ERB[alpha] mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines by Gibbs, Julie E, Blaikley, John, Beesley, Stephen, Matthews, Laura, Simpson, Karen D, Boyce, Susan H, Farrow, Stuart N, Else, Kathryn J, Singh, Dave, Ray, David W, Loudon, Andrew S I

“…Diurnal variation in inflammatory and immune function is evident in the physiology and pathology of humans and animals, but molecular mechanisms and mediating…”
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Increased Nerve Fiber Expression of Sensory Sodium Channels Navl.7, Navl.8, and Navl.9 in Rhinitis by KEH, Siew M, FACER, Paul, SIMPSON, Karen D, SANDHU, Guri, SALEH, Hesham A, ANAND, Praveen

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84. Patient Delivered Expedited Partner Therapy: Is this Acceptable to Adolescents and Young Adults? by Simpson, Karen, MD, FAAP, Silber, Tomas, MD, MASS, D'Angelo, Lawrence, MD, MPhH, Tuchman, Lisa, MD, MPH

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Intestinal type adenocarcinoma: a previously unrecognized histologic variant of ductal carcinoma of the pancreas by Albores-Saavedra, Jorge, MD, Simpson, Karen, MD, Dancer, Yeong-Ju, MD, Hruban, Ralph, MD

“…Abstract Adenocarcinomas with intestinal differentiation have been described in a wide variety of anatomical sites. To our knowledge, however, ductal…”
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Unusual findings in papillary thyroid microcarcinoma suggesting partial regression: a study of two cases by Simpson, Karen W., MD, Albores-Saavedra, Jorge, MD

“…Abstract Histologic changes of regression have been recognized in many malignant tumors, although they have not been documented in thyroid carcinoma. We…”
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