Search Results - "Simpson, Joshua D"

Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice by Chen, Liyu, Simpson, Joshua D, Fuchs, Adrian V, Rolfe, Barbara E, Thurecht, Kristofer J

“…Nanoscaled polymeric materials are increasingly being investigated as pharmaceutical products, drug/gene delivery vectors, or health-monitoring devices…”
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Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus by Shang, Pengcheng, Simpson, Joshua D., Taylor, Gwen M., Sutherland, Danica M., Welsh, Olivia L., Aravamudhan, Pavithra, Natividade, Rita Dos Santos, Schwab, Kristina, Michel, Joshua J., Poholek, Amanda C., Wu, Yijen, Rajasundaram, Dhivyaa, Koehler, Melanie, Alsteens, David, Dermody, Terence S.

“…Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and…”
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Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface by Simpson, Joshua D, Smith, Samuel A, Thurecht, Kristofer J, Such, Georgina

“…Nanomedicine has generated significant interest as an alternative to conventional cancertherapy due to the ability for nanoparticles to tune cargo release…”
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Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform by Arno, Maria C, Simpson, Joshua D, Blackman, Lewis D, Brannigan, Ruairí P, Thurecht, Kristofer J, Dove, Andrew P

“…Polymer-drug conjugates are widely investigated to enhance the selectivity of therapeutic drugs to cancer cells, as well as increase circulation lifetime and…”
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Role of the Redox State of Human Peroxiredoxin-5 on Its TLR4-Activating DAMP Function by Poncin, Mégane A, Van Meerbeeck, Pierre, Simpson, Joshua D, Clippe, André, Tyckaert, François, Bouillenne, Fabrice, Degand, Hervé, Matagne, André, Morsomme, Pierre, Knoops, Bernard, Alsteens, David

“…Human peroxiredoxin-5 (PRDX5) is a unique redox-sensitive protein that plays a dual role in brain ischemia-reperfusion injury. While intracellular PRDX5 has…”
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Single-Molecule Investigation of the Binding Interface Stability of SARS-CoV‑2 Variants with ACE2 by Ray, Ankita, Minh Tran, Thu Thi, Santos Natividade, Rita dos, Moreira, Rodrigo A., Simpson, Joshua D., Mohammed, Danahe, Koehler, Melanie, L Petitjean, Simon J., Zhang, Qingrong, Bureau, Fabrice, Gillet, Laurent, Poma, Adolfo B., Alsteens, David

“…The SARS-CoV-2 pandemic spurred numerous research endeavors to comprehend the virus and mitigate its global severity. Understanding the binding interface…”
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Cyanine-5-Driven Behaviours of Hyperbranched Polymers Designed for Therapeutic Delivery Are Cell-Type Specific and Correlated with Polar Lipid Distribution in Membranes by Simpson, Joshua D., Currin-Ross, Denni L., Ediriweera, Gayathri R., Schirra, Horst Joachim, Fletcher, Nicholas L., Bell, Craig A., Arno, Maria C., Thurecht, Kristofer J.

“…The ability to predict the behaviour of polymeric nanomedicines can often be obfuscated by subtle modifications to the corona structure, such as incorporation…”
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Atomic force microscopy applied to interrogate nanoscale cellular chemistry and supramolecular bond dynamics for biomedical applications by Simpson, Joshua D, Ray, Ankita, Koehler, Melanie, Mohammed, Danahe, Alsteens, David

“…Understanding biological interactions at a molecular level grants valuable information relevant to improving medical treatments and outcomes. Among the suite…”
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Single-Molecule Analysis of SARS-CoV‑2 Binding to C‑Type Lectin Receptors by Simpson, Joshua D., Ray, Ankita, Marcon, Claire, dos Santos Natividade, Rita, Dorrazehi, Gol Mohammad, Durlet, Kimberly, Koehler, Melanie, Alsteens, David

“…Despite intense scrutiny throughout the pandemic, development of efficacious drugs against SARS-CoV-2 spread remains hindered. Understanding the underlying…”
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Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic by Pearce, Amanda K., Simpson, Joshua D., Fletcher, Nicholas L., Houston, Zachary H., Fuchs, Adrian V., Russell, Pamela J., Whittaker, Andrew K., Thurecht, Kristofer J.

“…The therapeutic potential of hyperbranched polymers targeted to prostate cancer and loaded with doxorubicin was investigated. Polyethylene glycol hyperbranched…”
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Modulating Macrophage Clearance of Nanoparticles: Comparison of Small-Molecule and Biologic Drugs as Pharmacokinetic Modifiers of Soft Nanomaterials by Mills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J., Fletcher, Nicholas L.

“…Nanomedicines show benefits in overcoming the limitations of conventional drug delivery systems by reducing side effects, toxicity, and exhibiting enhanced…”
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Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics by Zhao, Yongmei, Houston, Zachary H, Simpson, Joshua D, Chen, Liyu, Fletcher, Nicholas L, Fuchs, Adrian V, Blakey, Idriss, Thurecht, Kristofer J

“…Theranostics is a strategy that combines multiple functions such as targeting, stimulus-responsive drug release, and diagnostic imaging into a single platform,…”
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Deciphering molecular mechanisms stabilizing the reovirus-binding complex by Dos Santos Natividade, Rita, Koehler, Melanie, Gomes, Priscila S F C, Simpson, Joshua D, Smith, Sydni Caet, Gomes, Diego E B, de Lhoneux, Juliette, Yang, Jinsung, Ray, Ankita, Dermody, Terence S, Bernardi, Rafael C, Ogden, Kristen M, Alsteens, David

“…Mammalian orthoreoviruses (reoviruses) serve as potential triggers of celiac disease and have oncolytic properties, making these viruses potential cancer…”
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Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery by Ediriweera, Gayathri R, Simpson, Joshua D, Fuchs, Adrian V, Venkatachalam, Taracad K, Van De Walle, Matthias, Howard, Christopher B, Mahler, Stephen M, Blinco, James P, Fletcher, Nicholas L, Houston, Zachary H, Bell, Craig A, Thurecht, Kristofer J

“…There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug…”
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Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells by Simpson, Joshua D, Ediriweera, Gayathri R, Howard, Christopher B, Fletcher, Nicholas L, Bell, Craig A, Thurecht, Kristofer J

“…As polymeric nanomedicines grow increasingly complex in design, an effective therapeutic release is often inherently tied to localisation to specific…”
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Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies by Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M., Thurecht, Kristofer J.

“…Targeted nanomaterials promise improved therapeutic efficacy, however their application in nanomedicine is limited due to complexities associated with protein…”
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Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models by Simpson, Joshua D, Monteiro, Patrícia F, Ediriweera, Gayathri R, Prior, Amber R, Sonderegger, Stefan E, Bell, Craig A, Fletcher, Nicholas L, Alexander, Cameron, Thurecht, Kristofer J

“…Improving our understanding of how design choices in materials synthesis impact biological outcomes is of critical importance in the development of…”
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Targeted Nanomaterials: Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv. Healthcare Mater. 16/2016) by Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M., Thurecht, Kristofer J.

“…Christopher B. Howard, and co‐workers report the generation of targeted nanomaterials for cancer theranostics by mixing of hyperbranched polyethylene glycol…”
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Oral Delivery of Multicompartment Nanomedicines for Colorectal Cancer Therapeutics: Combining Loco‐Regional Delivery with Cell‐Target Specificity by Akhter, Dewan T., Simpson, Joshua D., Fletcher, Nicholas L., Houston, Zachary H., Fuchs, Adrian V., Bell, Craig A., Thurecht, Kristofer J.

“…Nanomaterials for targeted delivery of chemotherapeutics have received significant attention owing to their potential to enhance the accumulation of…”
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