Search Results - "Simpson, Jean F."

Continued observation of the natural history of low-grade ductal carcinoma in situ reaffirms proclivity for local recurrence even after more than 30 years of follow-up by Sanders, Melinda E, Schuyler, Peggy A, Simpson, Jean F, Page, David L, Dupont, William D

“…Opportunities to study the natural history of ductal carcinoma in situ are rare. A few studies of incompletely excised lesions in the premammographic era,…”
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Prognostic Factors in Breast Cancer by Fitzgibbons, Patrick L, Page, David L, Weaver, Donald, Thor, Ann D, Allred, D. Craig, Clark, Gary M, Ruby, Stephen G, O'Malley, Frances, Simpson, Jean F, Connolly, James L, Hayes, Daniel F, Edge, Stephen B, Lichter, Allen, Schnitt, Stuart J

“…Abstract Background.—Under the auspices of the College of American Pathologists, a multidisciplinary group of clinicians, pathologists, and statisticians…”
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Metaplastic Spindle Cell Breast Tumors Arising within Papillomas, Complex Sclerosing Lesions, and Nipple Adenomas by Gobbi, Helenice, Simpson, Jean F, Jensen, Roy A, Olson, Sandra J, Page, David L

“…Micropapillomas/papillomas and complex sclerosing lesions of the breast have been associated with a slightly increased risk for subsequent carcinoma, although…”
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Neoadjuvant Concurrent Paclitaxel and Radiation in Stage II/III Breast Cancer by CHAKRAVARTHY, A. Bapsi, KELLEY, Mark C, JONES, Catherine, PIETENPOL, Jennifer A, MCLAREN, Bernadette, TRUICA, Cristina I, BILLHEIMER, Dean, MAYER, Ingrid A, GRAU, Ana M, JOHNSON, David H, SIMPSON, Jean F, BEAUCHAMP, R. Daniel

“…Purpose: The aim of this study was to determine the safety and pathologic response rates following neoadjuvant paclitaxel and radiation in patients with stage…”
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Artifactual Displacement of Ductal Carcinoma In Situ (ADDCIS) (Toothpaste Effect): A Mimicker of Invasive Ductal Carcinoma by Shabihkhani, Maryam, Simpson, Jean F., White, Marissa J., Cimino-Mathews, Ashley, Argani, Pedram

“…Needle tract displacement is a recognized mimicker of invasive ductal carcinoma (IDC). Artifactual displacement of ductal carcinoma in situ (ADDCIS)…”
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Blockade of the Epidermal Growth Factor Receptor Tyrosine Kinase Suppresses Tumorigenesis in MMTV/Neu + MMTV/TGF-α Bigenic Mice by Anne E. G. Lenferink, Simpson, Jean F., Shawver, Laura K., Coffey, Robert J., Forbes, James T., Arteaga, Carlos L.

“…Overexpression of ErbB-2/Neu has been causally associated with mammary epithelial transformation. Here we report that blockade of the epidermal growth factor…”
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Liposarcomatous differentiation in malignant phyllodes tumours is unassociated with MDM2 or CDK4 amplification by Lyle, Pamela L, Bridge, Julia A, Simpson, Jean F, Cates, Justin M, Sanders, Melinda E

“…Aims Breast sarcomas are rare, usually occurring in the setting of malignant phyllodes tumour (MPT). Heterologous differentiation commonly resembles…”
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Update on atypical epithelial hyperplasia and ductal carcinoma in situ by Simpson, Jean F.

“…Atypical ductal hyperplasia (ADH) as an indicator of increased risk for developing breast cancer is well established. Refinement in its molecular…”
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Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo by MOULDER, Stacy L, YAKES, F. Michael, MUTHUSWAMY, Senthil K, BIANCO, Roberto, SIMPSON, Jean F, ARTEAGA, Carlos L

“…Aberrrant signaling by the epidermal growth factor receptor [EGFR (HER1, erbB1)] and/or HER2/neu tyrosine kinases is present in a cohort of breast carcinomas…”
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The pathologist as a teacher by Simpson, Jean F, Washington, Kay

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Atypical lobular hyperplasia as a unilateral predictor of breast cancer risk: a retrospective cohort study by Page, David L, Schuyler, Peggy A, Dupont, William D, Jensen, Roy A, Plummer, W Dale, Simpson, Jean F

“…Clinical decisions about atypical lobular hyperplasia are based on the belief that later invasive breast-cancer risk is equal in both breasts. We aimed to show…”
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Histologic Associations and Long-term Cancer Risk in Columnar Cell Lesions of the Breast : A Retrospective Cohort and a Nested Case-Control Study by BOULOS, Fouad I, DUPONT, William D, SIMPSON, Jean F, SCHUYLER, Peggy A, SANDERS, Melinda E, FREUDENTHAL, Marcia E, PAGE, David L

“…Mammary columnar cell lesions with atypia have been receiving increased scrutiny in view of their association with atypical hyperplasia (AH) and carcinoma…”
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Differential Diagnosis of Proliferative Breast Lesions by Simpson, Jean F., MD, Boulos, Fouad I., MD

“…Abstract The correct diagnosis of proliferations within the mammary terminal duct-lobular unit has paramount prognostic and therapeutic implications…”
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Selective use of intraoperative touch prep analysis of sentinel nodes in breast cancer by Forbes, Rachel C, Pitchford, Clovis, Simpson, Jean F, Balch, Glen C, Kelley, Mark C

“…Imprint cytology (touch prep) is often used for intraoperative examination of sentinel nodes in breast cancer. This allows axillary lymph node dissection…”
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Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells by KUROKAWA, Hirokazu, LENFERINK, Anne E. G, SIMPSON, Jean F, PISACANE, Paul I, SLIWKOWSKI, Mark X, FORBES, James T, ARTEAGA, Carlos L

“…HER2/neu (erbB-2) overexpression has been causally associated with tamoxifen resistance in human breast cancer cells. Forced expression of HER2 in MCF-7 breast…”
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Intranodal Papillary Epithelial Proliferations: A Local Process With a Spectrum of Morphologies and Frequent Association With Papillomas in the Breast by Boulos, Fouad I., Granja, Nara M., Simpson, Jean F., O’Malley, Frances P., Saadeldine, Mothana M., Page, David L., Sanders, Melina E.

“…Lymph nodes, particularly those draining in major anatomic sites like axilla, pelvis, and neck are potential sites for the occasional presence of ectopic…”
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Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies by Sanders, Melinda E., Page, David L., Simpson, Jean F., Schuyler, Peggy A., Dale Plummer, W., Dupont, William D.

“…BACKGROUND Radial scars (RS) are benign breast lesions that have been implicated as independent risk factors for invasive breast carcinoma (IBC). METHODS A…”
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Definitive Diagnosis for High-Risk Breast Lesions Without Open Surgical Excision: The Intact Percutaneous Excision Trial (IPET) by Whitworth, Pat W., Simpson, Jean F., Poller, William R., Schonholz, Steven M., Turner, John F., Phillips, Rogsbert F., Johnson, Joel M., McEachin, F. David

“…Background Open surgical excision (OSE) is generally recommended when image-guided core-needle breast biopsy demonstrates a high-risk lesion (HRL). We…”
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Clinicopathologic Characteristics of Carcinomas That Develop After a Biopsy Containing Columnar Cell Lesions: Evidence Against a Precursor Role by BOULOS, Fouad I, DUPONT, William D, SCHUYLER, Peggy A, SANDERS, Melinda E, PAGE, David L, FEDDA, Faysal A, SIMPSON, Jean F

“…Columnar cell lesions are frequently associated with atypical ductal hyperplasia, lobular neoplasia, and tubular carcinoma, and have been suggested as a…”
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A Response to the “Call to Action” on Pathologic Reporting of Lymph Node Metastases in Differentiated Thyroid Cancer from the College of American Pathologists by Seethala, Raja R., Baker, Thomas P., Simpson, Jean F.

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