Search Results - "Simpson, Carrie"

In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles by Simpson, Carrie A., PhD, Salleng, Kenneth J., DVM, Cliffel, David E., PhD, Feldheim, Daniel L., PhD

“…Abstract Gold nanoparticles are emerging as promising materials from which to construct nanoscale therapeutics and therapeutic delivery systems. However,…”
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Short-Chain PEG Mixed Monolayer Protected Gold Clusters Increase Clearance and Red Blood Cell Counts by Simpson, Carrie A, Agrawal, Amanda C, Balinski, Andrzej, Harkness, Kellen M, Cliffel, David E

“…Monolayer-protected gold nanoparticles have great potential as novel building blocks for the design of new drugs and therapeutics based on the easy ability to…”
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Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-like Nano-Particle by Royal, Joshua M., Simpson, Carrie A., McCormick, Alison A., Phillips, Amanda, Hume, Steve, Morton, Josh, Shepherd, John, Oh, Youngjun, Swope, Kelsi, DeBeauchamp, Jennifer L., Webby, Richard J., Cross, Robert W., Borisevich, Viktoriya, Geisbert, Thomas W., Demarco, Jennifer K., Bratcher, Barry, Haydon, Hugh, Pogue, Gregory P.

“…Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a…”
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Nanoscale Structure–Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics by Bresee, Jamee, Bond, Constance M, Worthington, Roberta J, Smith, Candice A, Gifford, Jennifer C, Simpson, Carrie A, Carter, Carly J, Wang, Guankui, Hartman, Jesse, Osbaugh, Niki A, Shoemaker, Richard K, Melander, Christian, Feldheim, Daniel L

“…The emergence of resistance to multiple antimicrobial agents by pathogenic bacteria has become a significant global public health threat. Multi-drug-resistant…”
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Gastrointestinal Bioavailability of 2.0 nm Diameter Gold Nanoparticles by Smith, Candice A, Simpson, Carrie A, Kim, Ganghyeok, Carter, Carly J, Feldheim, Daniel L

“…The use of gold nanoparticles as imaging agents and therapeutic delivery systems is growing rapidly. However, a significant limitation of gold nanoparticles…”
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Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration by Kirby, Brett S., Voyles, Wyatt F., Simpson, Carrie B., Carlson, Rick E., Schrage, William G., Dinenno, Frank A.

“…Age-related increases in oxidative stress impair endothelium-dependent vasodilatation in humans, leading to the speculation that endothelial dysfunction…”
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Unexpected Toxicity of Monolayer Protected Gold Clusters Eliminated by PEG-Thiol Place Exchange Reactions by Simpson, Carrie A, Huffman, Brian J, Gerdon, Aren E, Cliffel, David E

“…Monolayer protected clusters (MPCs) are small, metal nanoparticles capped with thiolate ligands that have been widely studied for their size-dependent…”
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Reproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana by Swope, Kelsi, Morton, Josh, Pogue, Gregory P, Burden, Leigh, Partain, Nicholas, Hume, Steve, Shepherd, John, Simpson, Carrie A, Brennan, Miles B, Furman, Thomas C, Kingrey-Gebe, Sheila, Martinez, Theresa, McDonough, Jim, Pauly, Michael H, Whaley, Kevin J, Zeitlin, Larry, Bratcher, Barry, Haydon, Hugh

“…The ongoing SARS-CoV-2 coronavirus pandemic of 2020-2021 underscores the need for manufacturing platforms that can rapidly produce monoclonal antibody (mAb)…”
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Gold nanoparticles to improve HIV drug delivery by Garrido, Carolina, Simpson, Carrie A, Dahl, Noelle P, Bresee, Jamee, Whitehead, Daniel C, Lindsey, Erick A, Harris, Tyler L, Smith, Candice A, Carter, Carly J, Feldheim, Daniel L, Melander, Christian, Margolis, David M

“…Antiretroviral therapy (ART) has improved lifespan and quality of life of patients infected with the HIV-1. However, ART has several potential limitations,…”
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Student Perceptions of Hybrid Courses in Higher Education by Unger, Sanne, Simpson, Carrie, Lecher, Alanna, Goudreau, Shara B.

“…Online open-ended and closed-ended surveys were conducted in 2014-2016 among 191 students at a small, private university located in South Florida. Our main…”
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Safety Effectiveness of Flashing Yellow Arrow: Evaluation of 222 Signalized Intersections in North Carolina by Simpson, Carrie L., Troy, Shawn A.

“…The purpose of this project was to develop crash modification factors (CMFs) for the implementation of a flashing yellow arrow (FYA) on the basis of the…”
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Tiopronin Gold Nanoparticle Precursor Forms Aurophilic Ring Tetramer by Simpson, Carrie A, Farrow, Christopher L, Tian, Peng, Billinge, Simon J. L, Huffman, Brian J, Harkness, Kellen M, Cliffel, David E

“…In the two step synthesis of thiolate-monolayer protected clusters (MPCs), the first step of the reaction is a mild reduction of gold(III) by thiols that…”
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CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated Immunopathology by DeMarco, Jennifer K, Royal, Joshua M, Severson, William E, Gabbard, Jon D, Hume, Steve, Morton, Josh, Swope, Kelsi, Simpson, Carrie A, Shepherd, John W, Bratcher, Barry, Palmer, Kenneth E, Pogue, Gregory P

“…We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of…”
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A Structural Mass Spectrometry Strategy for the Relative Quantitation of Ligands on Mixed Monolayer-Protected Gold Nanoparticles by Harkness, Kellen M, Hixson, Brian C, Fenn, Larissa S, Turner, Brian N, Rape, Amanda C, Simpson, Carrie A, Huffman, Brian J, Okoli, Tracy C, McLean, John A, Cliffel, David E

“…It is becoming increasingly common to use gold nanoparticles (AuNPs) protected by a heterogeneous mixture of thiolate ligands, but many ligand mixtures on…”
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Manufacturing plant-made monoclonal antibodies for research or therapeutic applications by Swope, Kelsi, Morton, Josh, Pogue, Gregory P, Hume, Steve, Pauly, Michael H, Shepherd, John, Simpson, Carrie A, Bratcher, Barry, Whaley, Kevin J, Zeitlin, Larry, Davis, Keith R, Haydon, Hugh

“…Monoclonal antibodies (mAbs) hold great promise for treating diseases ranging from cancer to infectious disease. Manufacture of mAbs is challenging, expensive,…”
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Safety Effectiveness of “Vehicle Entering When Flashing” Signs: Evaluation of 74 Stop-Controlled Intersections in North Carolina by Simpson, Carrie L., Troy, Shawn A.

“…This project evaluated the safety effectiveness of “Vehicle Entering When Flashing” (VEWF) intersection conflict warning systems (ICWSs) at stop-controlled…”
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Safety Evaluation of Dual Left-Turn Lane Installations in North Carolina by Nye, Timothy, Simpson, Carrie

“…Crash modification factors (CMFs) were calculated for the conversion of a single left-turn lane to a dual or double left-turn lane (DLTL). Despite their…”
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Evaluation of Effectiveness of School Zone Flashers in North Carolina by Simpson, Carrie L.

“…The North Carolina Department of Transportation has been placing flashing beacons on school zone signs where warranted in an attempt to provide more awareness…”
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Dynamic All-Red Extension: An Innovative Safety Countermeasure to Treat Red Light Running Crashes by Simpson, Carrie L.

“…The purpose of this project was to evaluate the safety effectiveness of Dynamic All-Red Extension (DARE) systems. North Carolina Department of Transportation…”
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In vivo testing for gold nanoparticle toxicity by Simpson, Carrie A, Huffman, Brian J, Cliffel, David E

“…A technique for measuring the toxicity of nanomaterials using a murine model is described. Blood samples are collected via submandibular bleeding while urine…”
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