Search Results - "Simpson, Ann"

PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy by Haddadi, Nahal, Lin, Yiguang, Travis, Glena, Simpson, Ann M, Nassif, Najah T, McGowan, Eileen M

“…Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the integrity of fundamental cellular processes, cell growth,…”
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Anxiety Linked to COVID-19: A Systematic Review Comparing Anxiety Rates in Different Populations by Saeed, Hafsah, Eslami, Ardalan, Nassif, Najah T, Simpson, Ann M, Lal, Sara

“…The COVID-19 pandemic has incited a rise in anxiety, with uncertainty regarding the specific impacts and risk factors across multiple populations. A…”
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903-P: Correlation of Gene Expression and Cellular Pathways in Insulin-Expressing Mouse Liver Cells Transduced with an Integrating Adeno-associated Viral Vector (AAV) by JOSHUA, SERGIO, NASSIF, NAJAH T., SIMPSON, ANN M.

“…Gene therapy is being considered as a treatment/cure for type 1 diabetes (T1D). Previously we used a clinically-applicable AAV to deliver furin cleavable…”
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"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer by Haddadi, Nahal, Lin, Yiguang, Simpson, Ann M, Nassif, Najah T, McGowan, Eileen M

“…Sphingosine kinase (SphK) is a lipid enzyme that maintains cellular lipid homeostasis. Two SphK isozymes, SphK1 and SphK2, are expressed from different…”
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Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse by Lund, Maria E, O'Brien, Bronwyn A, Hutchinson, Andrew T, Robinson, Mark W, Simpson, Ann M, Dalton, John P, Donnelly, Sheila

“…Infections with helminth parasites prevent/attenuate auto-inflammatory disease. Here we show that molecules secreted by a helminth parasite could prevent Type…”
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Heart Rate Variability as a Biomarker for Predicting Stroke, Post-stroke Complications and Functionality by Lees, Ty, Shad-Kaneez, Fatima, Simpson, Ann M, Nassif, Najah T, Lin, Yiguang, Lal, Sara

“…Background: Heart rate variability (HRV) is a non-invasive measure of the function of the autonomic nervous system, and its dynamic nature may provide a means…”
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Short-chain fatty acids and insulin sensitivity: a systematic review and meta-analysis by Pham, Nhan H T, Joglekar, Mugdha V, Wong, Wilson K M, Nassif, Najah T, Simpson, Ann M, Hardikar, Anandwardhan A

“…Abstract Context There is substantial evidence that reduced short-chain fatty acids (SCFAs) in the gut are associated with obesity and type 2 diabetes,…”
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Luciferase-based reporting of suicide gene activity in murine mesenchymal stem cells by Gerace, Dario, Martiniello-Wilks, Rosetta, Habib, Rosaline, Simpson, Ann Margaret

“…Due to their ease of isolation, gene modification and tumor-homing properties, mesenchymal stem cells (MSCs) are an attractive cellular vehicle for the…”
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PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision Targeting in Cancer Therapeutics by Travis, Glena, McGowan, Eileen M., Simpson, Ann M., Marsh, Deborah J., Nassif, Najah T.

“…The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a well characterised tumour suppressor, playing a critical role in the maintenance of…”
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Antiphospholipid Antibodies and Recurrent Thrombotic Events: Persistence and Portfolio by Amory, Colum F, Levine, Steven R, Brey, Robin L, Gebregziabher, Mulugeta, Tuhrim, Stanley, Tilley, Barbara C, Simpson, Ann-Catherin C, Sacco, Ralph L, Mohr, Jay P

“…There are very limited prospective data on the significance of persistent antiphospholipid antibodies (aPL) and recurrent thrombo-occlusive events (TOEs). We…”
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Spatial patterns of international migrant resident settlement and incorporation in Winnipeg Manitoba by Simpson, Sheryl‐Ann

“…Comparing the settlement patterns of two cohorts of international movers (2001–2006 and 2010–2011) in Winnipeg, Manitoba, highlights the relationships between…”
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Unraveling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks by John, Alka Rachel, Singh, Avinash K., Do, Tien-Thong Nguyen, Eidels, Ami, Nalivaiko, Eugene, Gavgani, Alireza Mazloumi, Brown, Scott, Bennett, Murray, Lal, Sara, Simpson, Ann M., Gustin, Sylvia M., Double, Kay, Walker, Frederick Rohan, Kleitman, Sabina, Morley, John, Lin, Chin-Teng

“…Modern work environments have extensive interactions with technology and greater cognitive complexity of the tasks, which results in human operators…”
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Histopathological Changes Induced by Malassezin: A Novel Natural Microbiome Indole for Treatment of Facial Hyperpigmentation by Grimes, Pearl, Bhawan, Jag, Howell, Michael, Desai, Seemal, Coryell, Edna, Einziger, Michael, Simpson, Ann, Yaroshinsky, Alex, McCraw, Tim

“…Malassezin is a natural indole compound produced by the fungus Malassezia furfur and preclinical investigations have demonstrated an ability to suppress…”
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A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis by Lund, Maria E., Greer, Judith, Dixit, Aakanksha, Alvarado, Raquel, McCauley-Winter, Padraig, To, Joyce, Tanaka, Akane, Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., O’Brien, Bronwyn A., Dalton, John P., Donnelly, Sheila

“…Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of…”
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Severe weather over the Highveld of South Africa during November 2016 by Simpson, Lee-ann, Dyson, Liesl

“…November months are notorious for severe weather over the Highveld of South Africa. November 2016 was no exception and a large number of severe events…”
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Toward Systems Pathology for PTEN Diagnostics by Haddadi, Nahal, Travis, Glena, Nassif, Najah T, Simpson, Ann M, Marsh, Deborah J

“…Germline alterations of the tumor suppressor PTEN have been extensively characterized in patients with PTEN hamartoma tumor syndromes, encompassing subsets of…”
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Transcriptomic Analysis of Insulin-Secreting Murine Hepatocytes Transduced with an Integrating Adeno-Associated Viral Vector by Mahoney, Alexandra L. G., Joshua, Sergio, Nassif, Najah T., Simpson, Ann M.

“…Type 1 Diabetes (T1D) is a chronic metabolic disorder for which current treatments are unable to prevent the onset of complications. Previously, we used an…”
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Incidence of death and potentially life‐threatening near‐miss events in living donor hepatic lobectomy: A world‐wide survey by Cheah, Yee Lee, Simpson, Mary Ann, Pomposelli, James J., Pomfret, Elizabeth A.

“…The incidence of morbidity and mortality after living donor liver transplantation (LDLT) is not well understood because reporting is not standardized and…”
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Pancreatic Transdifferentiation Using β-Cell Transcription Factors for Type 1 Diabetes Treatment by Mahoney, Alexandra L. G., Nassif, Najah T., O’Brien, Bronwyn A., Simpson, Ann M.

“…Type 1 diabetes is a chronic illness in which the native beta (β)-cell population responsible for insulin release has been the subject of autoimmune…”
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Pancreatic Transdifferentiation and Glucose-Regulated Production of Human Insulin in the H4IIE Rat Liver Cell Line by Ren, Binhai, Tao, Chang, Swan, Margaret Anne, Joachim, Nichole, Martiniello-Wilks, Rosetta, Nassif, Najah T, O'Brien, Bronwyn A, Simpson, Ann M

“…Due to the limitations of current treatment regimes, gene therapy is a promising strategy being explored to correct blood glucose concentrations in diabetic…”
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