Search Results - "Simpson, Alexander P."

Fcγ receptors and immunomodulatory antibodies in cancer by Galvez-Cancino, Felipe, Simpson, Alexander P., Costoya, Cristobal, Matos, Ignacio, Qian, Danwen, Peggs, Karl S., Litchfield, Kevin, Quezada, Sergio A.

“…The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) as negative regulators of antitumour…”
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FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms by Simpson, Alexander P., Roghanian, Ali, Oldham, Robert J., Chan, H.T. Claude, Penfold, Christine A., Kim, Hyung J., Inzhelevskaya, Tatyana, Mockridge, C. Ian, Cox, Kerry L., Bogdanov, Yury D., James, Sonya, Tutt, Alison L., Rycroft, Daniel, Morley, Peter, Dahal, Lekh N., Teige, Ingrid, Frendeus, Björn, Beers, Stephen A., Cragg, Mark S.

“…Many therapeutic antibodies deplete target cells and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These…”
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