Search Results - "Simons, W. W"

Nanotechnology applications in cancer by Nie, Shuming, Xing, Yun, Kim, Gloria J, Simons, Jonathan W

“…Cancer nanotechnology is an interdisciplinary area of research in science, engineering, and medicine with broad applications for molecular imaging, molecular…”
Get full text

Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer by Yochum, Zachary A., Cades, Jessica, Wang, Hailun, Chatterjee, Suman, Simons, Brian W., O’Brien, James P., Khetarpal, Susheel K., Lemtiri-Chlieh, Ghali, Myers, Kayla V., Huang, Eric H.-B., Rudin, Charles M., Tran, Phuoc T., Burns, Timothy F.

“…Patients with EGFR- mutant non-small-cell lung cancer (NSCLC) have significantly benefited from the use of EGFR tyrosine kinase inhibitors (TKIs). However,…”
Get full text

Tracking the clonal origin of lethal prostate cancer by Haffner, Michael C, Mosbruger, Timothy, Esopi, David M, Fedor, Helen, Heaphy, Christopher M, Walker, David A, Adejola, Nkosi, Gürel, Meltem, Hicks, Jessica, Meeker, Alan K, Halushka, Marc K, Simons, Jonathan W, Isaacs, William B, De Marzo, Angelo M, Nelson, William G, Yegnasubramanian, Srinivasan

“…Recent controversies surrounding prostate cancer overtreatment emphasize the critical need to delineate the molecular features associated with progression to…”
Get full text

Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee by ITTMANN, Michael, JIAOTI HUANG, LODA, Massimo, THOMAS, George, BOROWSKY, Alexander, CARDIFF, Robert D, RADAELLI, Enrico, MARTIN, Philip, SIGNORETTI, Sabina, SULLIVAN, Ruth, SIMONS, Brian W, WARD, Jerrold M, ROBINSON, Brian D, CHU, Gerald C

“…Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue…”
Get full text

Long-term impacts of rising sea temperature and sea level on shallow water coral communities over a ~40 year period by Brown, B. E., Dunne, R. P., Somerfield, P. J., Edwards, A. J., Simons, W. J. F., Phongsuwan, N., Putchim, L., Anderson, L., Naeije, M. C.

“…Effects of combined rising sea temperature and increasing sea level on coral reefs, both factors associated with global warming, have rarely been addressed. In…”
Get full text

A Transient in Surface Motions Dominated by Deep Afterslip Subsequent to a Shallow Supershear Earthquake: The 2018 Mw7.5 Palu Case by N. Nijholt, W. J. F. Simons, J. Efendi, D. A. Sarsito, R. E. M. Riva

“…Abstract The 2018 Mw7.5 Palu earthquake is a remarkable strike‐slip event due to its nature as a shallow supershear fault rupture across several segments and a…”
Get full text

TWIST1-WDR5- Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis by Malek, Reem, Gajula, Rajendra P, Williams, Russell D, Nghiem, Belinda, Simons, Brian W, Nugent, Katriana, Wang, Hailun, Taparra, Kekoa, Lemtiri-Chlieh, Ghali, Yoon, Arum R, True, Lawrence, An, Steven S, DeWeese, Theodore L, Ross, Ashley E, Schaeffer, Edward M, Pienta, Kenneth J, Hurley, Paula J, Morrissey, Colm, Tran, Phuoc T

“…TWIST1 is a transcription factor critical for development that can promote prostate cancer metastasis. During embryonic development, TWIST1 and HOXA9 are…”
Get full text

In vivo molecular and cellular imaging with quantum dots by Gao, Xiaohu, Yang, Lily, Petros, John A, Marshall, Fray F, Simons, Jonathan W, Nie, Shuming

“…Quantum dots (QDs), tiny light-emitting particles on the nanometer scale, are emerging as a new class of fluorescent probe for in vivo biomolecular and…”
Get full text

Insight into the 2004 Sumatra-Andaman earthquake from GPS measurements in southeast Asia by Vigny, C, Simons, W. J. F, Abu, S, Bamphenyu, Ronnachai, Satirapod, Chalermchon, Choosakul, Nithiwatthn, Subarya, C, Socquet, A, Omar, K, Abidin, H. Z, Ambrosius, B. A. C

“…Data collected at approximately 60 Global Positioning System (GPS) sites in southeast Asia show the crustal deformation caused by the 26 December 2004…”
Get full text

Clinical Evaluation and Validation of the Dutch Crosslinking for Keratoconus Score by Wisse, Robert P L, Simons, Rob W P, van der Vossen, Martijn J B, Muijzer, Marc B, Soeters, Nienke, Nuijts, Rudy M M A, Godefrooij, Daniel A

“…Defining keratoconus progression is fundamental in clinical decision making because crosslinking treatments are indicated when the disease is considered…”
Get more information

Hypoxia-inducible factor-1 in human breast and prostate cancer by Kimbro, K S, Simons, J W

“…The tumor microenvironment is best characterized as a fluctuation of hypoxia and nutrient deprivation, which leads to epigenetic and genetic adaptation of…”
Get full text

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression by Hughes, Robert M, Simons, Brian W, Khan, Hamda, Miller, Rebecca, Kugler, Valentina, Torquato, Samantha, Theodros, Debebe, Haffner, Michael C, Lotan, Tamara, Huang, Jessie, Davicioni, Elai, An, Steven S, Riddle, Ryan C, Thorek, Daniel L J, Garraway, Isla P, Fertig, Elana J, Isaacs, John T, Brennen, W Nathaniel, Park, Ben H, Hurley, Paula J

“…Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple cell types within the tumor microenvironment. Here…”
Get full text

Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells by Graham, Tisheeka R, Zhau, Haiyen E, Odero-Marah, Valerie A, Osunkoya, Adeboye O, Kimbro, K Sean, Tighiouart, Mourad, Liu, Tongrui, Simons, Jonathan W, O'Regan, Ruth M

“…The epithelial-to-mesenchymal transition (EMT) is crucial for the migration and invasion of many epithelial tumors, including prostate cancer. Although it is…”
Get full text

A decade of GPS in Southeast Asia: Resolving Sundaland motion and boundaries by Simons, W. J. F., Socquet, A., Vigny, C., Ambrosius, B. A. C., Haji Abu, S., Promthong, Chaiwat, Subarya, C., Sarsito, D. A., Matheussen, S., Morgan, P., Spakman, W.

“…A unique GPS velocity field that spans the entire Southeast Asia region is presented. It is based on 10 years (1994–2004) of GPS data at more than 100 sites in…”
Get full text

SPHY v2.0: Spatial Processes in HYdrology by Terink, W, Lutz, A. F, Simons, G. W. H, Immerzeel, W. W, Droogers, P

“…This paper introduces and presents the Spatial Processes in HYdrology (SPHY) model (v2.0), its development background, its underlying concepts, and some…”
Get full text

Importance of horizontal seafloor motion on tsunami height for the 2011 Mw=9.0 Tohoku-Oki earthquake by Hooper, A., Pietrzak, J., Simons, W., Cui, H., Riva, R., Naeije, M., Terwisscha van Scheltinga, A., Schrama, E., Stelling, G., Socquet, A.

“…It is now clear that the 2011 Tohoku-Oki earthquake ruptured the subduction interface all the way to the Japan Trench. However, there is significant…”
Get full text

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer by Graham, Mindy K., Wang, Rulin, Chikarmane, Roshan, Abel, Bulouere, Vaghasia, Ajay, Gupta, Anuj, Zheng, Qizhi, Hicks, Jessica, Sysa-Shah, Polina, Pan, Xin, Castagna, Nicole, Liu, Jianyong, Meyers, Jennifer, Skaist, Alyza, Zhang, Yan, Rubenstein, Michael, Schuebel, Kornel, Simons, Brian W., Bieberich, Charles J., Nelson, William G., Lupold, Shawn E., DeWeese, Theodore L., De Marzo, Angelo M., Yegnasubramanian, Srinivasan

“…How prostate cancer cells and their precursors mediate changes in the tumor microenvironment (TME) to drive prostate cancer progression is unclear, in part due…”
Get full text

SHRINE: enabling nationally scalable multi-site disease studies by McMurry, Andrew J, Murphy, Shawn N, MacFadden, Douglas, Weber, Griffin, Simons, William W, Orechia, John, Bickel, Jonathan, Wattanasin, Nich, Gilbert, Clint, Trevvett, Philip, Churchill, Susanne, Kohane, Isaac S

“…Results of medical research studies are often contradictory or cannot be reproduced. One reason is that there may not be enough patient subjects available for…”
Get full text

[18F]-Labeled PARP-1 PET imaging of PSMA targeted alpha particle radiotherapy response by Zhang, Hanwen, Abou, Diane, Lu, Peng, Hasson, Abbie Meghan, Villmer, Alexandria, Benabdallah, Nadia, Jiang, Wen, Ulmert, David, Carlin, Sean, Rogers, Buck E., Turtle, Norman F., McDevitt, Michael R., Baumann, Brian, Simons, Brian W., Dehdashti, Farrokh, Zhou, Dong, Thorek, Daniel L. J.

“…The growing interest and clinical translation of alpha particle (α) therapies brings with it new challenges to assess target cell engagement and to monitor…”
Get full text

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF by Mabjeesh, Nicola J., Escuin, Daniel, LaVallee, Theresa M., Pribluda, Victor S., Swartz, Glenn M., Johnson, Michelle S., Willard, Margaret T., Zhong, Hua, Simons, Jonathan W., Giannakakou, Paraskevi

“…Inhibition of angiogenesis is an important new modality for cancer treatment. 2-methoxyestradiol (2ME2) is a novel antitumor and antiangiogenic agent,…”
Get full text