Search Results - "Simons, R W"

Cost-effectiveness of immediate versus delayed sequential bilateral cataract surgery in the Netherlands (the BICAT-NL study): study design of a prospective multicenter randomised controlled trial by Spekreijse, L S, Simons, R W P, Winkens, B, van den Biggelaar, F J H M, Dirksen, C D, Nuijts, R M M A

“…Cataract surgery is one of the most frequently performed types of surgery. Most patients suffer from bilateral cataract and while cataract surgery of only one…”
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A population-based European cohort study of persistence in newly diagnosed hypertensive patients by HASFORD, J, MIMRAN, A, SIMONS, W. R

“…This study assessed the percentage of patients after 1 year who persisted on initially prescribed antihypertensive therapy. Medical records of 2416 patients…”
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Cold‐temperature induction of Escherichia coli polynucleotide phosphorylase occurs by reversal of its autoregulation by Beran, Rudolf K., Simons, Robert W.

“…When Escherichia coli cells are shifted to low temperatures (e.g. 15°C), growth halts while the ‘cold shock response’ (CSR) genes are induced, after which…”
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Improved single and multicopy lac-based cloning vectors for protein and operon fusions by Simons, R W, Houman, F, Kleckner, N

“…We describe several new vectors for the construction of operon and protein fusions to the Escherichia coli lacZ gene. In vitro constructions utilize multicopy…”
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Does rapid transition to insulin therapy in subjects with newly diagnosed type 2 diabetes mellitus benefit glycaemic control and diabetes-related complications? A German population-based study by Simons, W R, Vinod, H D, Gerber, R A, Bolinder, B

“…The aim of this study was to assess whether earlier transition to insulin in subjects with newly diagnosed type 2 diabetes improves glycaemic control and…”
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Variations in compliance among hypertensive patients by drug class: implications for health care costs by Rizzo, John A., Robert Simons, W.

“…Health care decision-makers require more information on differences in compliance rates associated with alternative classes of antihypertensive drugs and the…”
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Antisense RNA control in bacteria, phages, and plasmids by GERHART, E, WAGNER, H, SIMONS, R. W

“…Antisense RNA control is now recognized as an efficient and specific means of regulating gene expression at the posttranscriptional level. Almost all naturally…”
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Biological Regulation by Antisense RNA in Prokaryotes by Simons, R W, Kleckner, N

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Insertion sequence IS10 anti-sense pairing initiates by an interaction between the 5' end of the target RNA and a loop in the anti-sense RNA by Kittle, J D, Simons, R W, Lee, J, Kleckner, N

“…Transposition of insertion sequence IS10 is regulated by an anti-sense RNA which inhibits transposase expression when IS10 is present in multiple copies per…”
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Decay of the IS10 antisense RNA by 3' exoribonucleases: evidence that RNase II stabilizes RNA-OUT against PNPase attack by Pepe, C M, Maslesa-Galić, S, Simons, R W

“…RNA-OUT, the 69-nucleotide antisense RNA that regulates Tn10/IS10 transposition folds into a simple stem-loop structure. The unusually high metabolic stability…”
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Reverse Transcriptase-Mediated Tropism Switching in Bordetella Bacteriophage by Liu, Minghsun, Deora, Rajendar, Doulatov, Sergei R., Gingery, Mari, Eiserling, Frederick A., Preston, Andrew, Maskell, Duncan J., Simons, Robert W., Cotter, Peggy A., Parkhill, Julian, Miller, Jeff F.

“…Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that…”
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Translational control of IS10 transposition by Simons, R W, Kleckner, N

“…We present genetic evidence that insertion sequence IS10, the active element in transposon Tn10, can negatively control expression of its own transposase…”
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Effect of improved disease management strategies on hospital length of stay in the treatment of congestive heart failure by Simons, W.Roberts, Haim, Muriel, Rizzo, John, Zannad, Faiez

“…Congestive heart failure (CHF) afflicts more than 4.6 million people in the United States and increases at a rate of 400,000 newly diagnosed patients per year…”
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The IS10 antisense RNA blocks ribosome binding at the transposase translation initiation site by Ma, C., Simons, R.W.

“…Transposase (tnp) expression from insertion sequence IS10 is controlled, in part, by an antisense RNA, RNA‐OUT, which pairs to the translation initiation…”
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Chromosomal supercoiling in Escherichia coli by Miller, W G, Simons, R W

“…The Escherichia coli chromosome is compacted into 40-50 negatively supercoiled domains. It has been proposed that these domains differ in superhelical density…”
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The unusual stability of the IS10 anti‐sense RNA is critical for its function and is determined by the structure of its stem‐domain by Case, C.C., Roels, S.M., Jensen, P.D., Lee, J., Kleckner, N., Simons, R.W.

“…IS10 transposition is regulated by an approximately 70 nt anti‐sense RNA, RNA‐OUT. RNA‐OUT folds into a duplex ‘stem‐domain’ topped by a loosely paired…”
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DNA Sequence Organization of IS10-Right of TN10 and Comparison with IS10-Left by Halling, S. M., Simons, R. W., Way, J. C., Walsh, R. B., Kleckner, N.

“…Tn10 is 9,300 base pairs long and has inverted repeats of an insertion sequence (IS)-like sequence (IS10) at its ends. IS10-right provides all of the…”
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Structure and regulation of the Salmonella typhimurium rnc-era-recO operon by Anderson, P.E., Matsunaga, J., Simons, E.L., Simons, R.W.

“…The Escherichia coli rnc-era-recO operon encodes ribonuclease III (RNase III; a dsRNA endonuclease involved in rRNA and mRNA processing and decay), Era (an…”
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DNA from diverse sources manifests cryptic low-level transcription in Escherichia coli by Miller, W G, Simons, R W

“…We present evidence that DNA from diverse prokaryotic and eukaryotic sources gives rise to low-level fusion expression in Escherichia coli promoter-probe…”
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Health economics and outcomes research with retrospective data by Simons, W R, Smith, M E

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