Search Results - "Simons, Paul"

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology by Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia

“…The development of new therapies to slow down or halt the progression of Parkinson’s disease is a health care priority. A key pathological feature is the…”
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Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway by Killick, R, Ribe, E M, Al-Shawi, R, Malik, B, Hooper, C, Fernandes, C, Dobson, R, Nolan, P M, Lourdusamy, A, Furney, S, Lin, K, Breen, G, Wroe, R, To, A W M, Leroy, K, Causevic, M, Usardi, A, Robinson, M, Noble, W, Williamson, R, Lunnon, K, Kellie, S, Reynolds, C H, Bazenet, C, Hodges, A, Brion, J-P, Stephenson, J, Paul Simons, J, Lovestone, Simon

“…Although the mechanism of Aβ action in the pathogenesis of Alzheimer’s disease (AD) has remained elusive, it is known to increase the expression of the…”
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Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis by Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R., Gilbertson, Janet A., Botcher, Nicola, Canetti, Diana, Taylor, Graham W., Rendell, Nigel, Tennent, Glenys A., Verona, Guglielmo, Porcari, Riccardo, Mangione, P. Patrizia, Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio, Hawkins, Philip N., Al-Shawi, Raya, Simons, J. Paul

“…Cardiac ATTR amyloidosis, a serious but much under-diagnosed form of cardiomyopathy, is caused by deposition of amyloid fibrils derived from the plasma protein…”
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Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity by Parkinson, David B, Feltri, M Laura, Jessen, Kristján R, D'Antonio, Maurizio, Wilton, Daniel K, Mirsky, Rhona, Meijer, Dies, Woodhoo, Ashwin, Radtke, Freddy, Shen, Jie, Droggiti, Anna, Simons, Paul, Alonso, Maria B Duran, Guillemot, Francois, Wrabetz, Lawrence, Turmaine, Mark, Al-Shawi, Raya

“…Although the role of Notch signaling in CNS glial development is well established, its participation in peripheral glial development is still unclear. This…”
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C‐reactive protein is essential for innate resistance to pneumococcal infection by Paul Simons, J., Loeffler, Jutta M., Al‐Shawi, Raya, Ellmerich, Stephan, Hutchinson, Winston L., Tennent, Glenys A., Petrie, Aviva, Raynes, John G., Souza, J. Brian, Lawrence, Rachel A., Read, Kevin D., Pepys, Mark B.

“…Summary No deficiency of human C‐reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not…”
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Pathogenetic mechanisms of amyloid A amyloidosis by Simons, J. Paul, Al-Shawib, Raya, Ellmerich, Stephan, Speck, Ivana, Aslam, Samrina, Hutchinson, Winston L., Mangione, Palma P., Disterer, Petra, Gilbertson, Janet A., Hunt, Toby, Millar, David J., Minogue, Shane, Bodin, Karl, Pepys, Mark B., Hawkins, Philip N.

“…Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited…”
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Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice by Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al-Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El-Andaloussi, Samir, Alvarez-Erviti, Lydia

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Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells by Lopes da Silva, Mafalda, O'Connor, Marie N, Kriston-Vizi, Janos, White, Ian J, Al-Shawi, Raya, Simons, J Paul, Mössinger, Julia, Haucke, Volker, Cutler, Daniel F

“…Weibel-Palade bodies (WPBs) are endothelial storage organelles that mediate the release of molecules involved in thrombosis, inflammation and angiogenesis,…”
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Arthroscopic Minced Cartilage Implantation for Chondral Lesions at the Talus: A Technical Note by Roth, Klaus Edgar, Ossendorff, Robert, Klos, Kajetan, Simons, Paul, Drees, Philipp, Salzmann, Gian M.

“…In the past few years, autologous chondrocyte implantation has been shown to be the most suitable cartilage reconstructive technique with the best tissue…”
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Biomechanical investigation of two plating systems for medial column fusion in foot by Simons, Paul, Sommerer, Theresia, Zderic, Ivan, Wahl, Dieter, Lenz, Mark, Skulev, Hristo, Knobe, Matthias, Gueorguiev, Boyko, Richards, R Geoff, Klos, Kajetan

“…Arthrodesis of the medial column (navicular, cuneiform I and metatarsal I) is performed for reasons such as Charcot arthropathy, arthritis, posttraumatic…”
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A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo by Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio

“…Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of…”
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Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity by Kimura, Atsuko, Stevenson, Paula L., Carter, Roderick N., MacColl, Gavin, French, Karen L., Paul Simons, J., Al-Shawi, Raya, Kelly, Valerie, Chapman, Karen E., Holmes, Megan C.

“…The 5‐HT2C receptor has been implicated in mood and eating disorders. In general, it is accepted that 5‐HT2C receptor agonists increase anxiety behaviours and…”
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Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β2-Microglobulin by Halabelian, Levon, Ricagno, Stefano, Giorgetti, Sofia, Santambrogio, Carlo, Barbiroli, Alberto, Pellegrino, Sara, Achour, Adnane, Grandori, Rita, Marchese, Loredana, Raimondi, Sara, Mangione, P. Patrizia, Esposito, Gennaro, Al-Shawi, Raya, Simons, J. Paul, Speck, Ivana, Stoppini, Monica, Bolognesi, Martino, Bellotti, Vittorio

“…To form extracellular aggregates, amyloidogenic proteins bypass the intracellular quality control, which normally targets unfolded/aggregated polypeptides…”
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Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo by Al-Shawi, Raya, Tennent, Glenys A., Millar, David J., Richard-Londt, Angela, Brandner, Sebastian, Werring, David J., Simons, J. Paul, Pepys, Mark B.

“…Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid…”
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The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle by Ates, Kenan, Yang, Shi Yu, Orrell, Richard W., Sinanan, Andrea C.M., Simons, Paul, Solomon, Andrew, Beech, Steven, Goldspink, Geoffrey, Lewis, Mark P.

“…The effects of muscle splice variants of insulin-like growth factor I (IGF-I) on proliferation and differentiation were studied in human primary muscle cell…”
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Oligonucleotide-mediated gene editing is underestimated in cells expressing mutated green fluorescent protein and is positively associated with target protein expression by Disterer, Petra, Papaioannou, Ioannis, Evans, Vanessa C., Paul Simons, J., Owen, James S.

“…Background Single‐stranded DNA oligonucleotides (ssODNs) can introduce small, specific sequence alterations into genomes. Potential applications include…”
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Influence of tibialis posterior muscle activation on foot anatomy under axial loading: A biomechanical CT human cadaveric study by Dullaert, Koen, MD, Hagen, Jennifer E., MD, Simons, Paul, MD, Gras, Florian, MD PD, Gueorguiev, Boyko, PhD, Richards, R. Geoff, PhD, Klos, Kajetan, MD PD

“…Highlights • Effect weight bearing has on foot configuration investigated. • Actuation of TP tendon does not reconstitute medial longitudinal arch integrity…”
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First Tarsometatarsal Arthrodesis: An Anatomic Evaluation of Dorsomedial Versus Plantar Plating by Simons, Paul, Dr med, Fröber, Rosemarie, Dr med, Loracher, Clemens, Dr med, Knobe, Matthias, PD Dr med habil, Gras, Florian, PD Dr med habil, Hofmann, Gunther O., Prof Dr med Dr rer nat, Klos, Kajetan, PD Dr med habil

“…Abstract Fusion of the first tarsometatarsal joint is a widely used procedure for the correction of hallux valgus deformity. Although dorsomedial H -shaped…”
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Lateral soft-tissue release through a medial incision: Anatomic comparison of two techniques by Simons, Paul, Klos, Kajetan, Loracher, Clemens, Skulev, Hristo K, Gras, Florian, Hofmann, Gunther O, Fröber, Rosemarie

“…Highlights • Techniques for a lateral release via a medial incision were examined. • Release was performed using a transarticular approach or a dorsal flap. •…”
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Reconstruction of the lateral tibia plateau fracture with a third triangular support screw: A biomechanical study by Moran, Eduardo, Zderic, Ivan, Klos, Kajetan, Simons, Paul, Triana, Miguel, Richards, R. Geoff, Gueorguiev, Boyko, Lenz, Mark

“…Split fractures of the lateral tibia plateau in young patients with good bone quality are commonly treated using two minimally invasive percutaneous lag…”
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