Search Results - "Simons, Karin H"

Vein graft failure: from pathophysiology to clinical outcomes by de Vries, Margreet R., Simons, Karin H., Jukema, J. Wouter, Braun, Jerry, Quax, Paul H. A.

“…Key Points Thrombosis, constrictive remodelling, intimal hyperplasia, and unstable atherosclerotic lesions are the critical mechanisms contributing to vein…”
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bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3Leiden mice by Parma, Laura, Peters, Hendrika A. B., Sluiter, Thijs J., Simons, Karin H., Lazzari, Paolo, de Vries, Margreet R., Quax, Paul H. A.

“…Intraplaque angiogenesis increases the chance of unstable atherosclerotic plaque rupture and thrombus formation leading to myocardial infarction. Basic…”
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Circulating Small Non-coding RNAs as Biomarkers for Recovery After Exhaustive or Repetitive Exercise by Håkansson, Kjell E J, Sollie, Ove, Simons, Karin H, Quax, Paul H A, Jensen, Jørgen, Nossent, A Yaël

“…Circulating microRNAs have proven to be reliable biomarkers, due to their high stability, both in the circulation, and during sample preparation and storage…”
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Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia by van der Kwast, Reginald V.C.T., Parma, Laura, van der Bent, M. Leontien, van Ingen, Eva, Baganha, Fabiana, Peters, Hendrika A.B., Goossens, Eveline A.C., Simons, Karin H., Palmen, Meindert, de Vries, Margreet R., Quax, Paul H.A., Nossent, A. Yaël

“…Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public…”
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miRMap: Profiling 14q32 microRNA Expression and DNA Methylation Throughout the Human Vasculature by Goossens, Eveline A C, de Vries, Margreet R, Simons, Karin H, Putter, Hein, Quax, Paul H A, Nossent, A Yaël

“…MicroRNAs are regulators of (patho)physiological functions with tissue-specific expression patterns. However, little is known about inter-vascular differences…”
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Short-Term Clinical Outcome of Hemiarthroplasty Versus Arthrodesis for End-Stage Hallux Rigidus by Simons, Karin H., MD, van der Woude, Pieter, MD, Faber, Frank W.M., MD, PhD, van Kampen, Paulien M., PhD, Thomassen, Bregje J.W., PhD

“…Abstract Few data are available to compare the outcomes of first metatarsophalangeal joint (MTPJ) hemiarthroplasty and arthrodesis. We included 46 patients who…”
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CD8+ T Cells Protect During Vein Graft Disease Development by Simons, Karin H, de Vries, Margreet R, Peters, Hendrika A B, Jukema, J Wouter, Quax, Paul H A, Arens, Ramon

“…Vein grafts are frequently used conduits for arterial reconstruction in patients with cardiovascular disease. Unfortunately, vein graft disease (VGD) causes…”
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T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword by Simons, Karin H., de Jong, Alwin, Jukema, J. Wouter, de Vries, Margreet R., Arens, Ramon, Quax, Paul H. A.

“…The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and…”
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IRF3 and IRF7 mediate neovascularization via inflammatory cytokines by Simons, Karin H., Vries, Margreet R., Jong, Rob C. M., Peters, Hendrika A. B., Jukema, J. Wouter, Quax, Paul H. A.

“…Objective To elucidate the role of interferon regulatory factor (IRF)3 and IRF7 in neovascularization. Methods Unilateral hind limb ischaemia was induced in…”
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Abstract 15552: Interferon Regulatory Factors 3 and 7 Regulate Vein Graft Remodeling via Tumor Necrosis Factor Induced Macrophage Accumulation by Simons, Karin H, de Vries, Margreet R, Peters, Erna A, Hamming, Jaap F, Jukema, J W, Quax, Paul H

“…IntroductionVein grafts are used to bypass atherosclerotic lesions; however, patency rates of these grafts are poor. Inflammation driven by toll like receptors…”
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