Search Results - "Simonian, R A"

Inhibition of the alternative oxidase stimulates H2O2 production in plant mitochondria by Popov, V.N, Simonian, R.A, Skulachev, V.P, Starkov, A.A

“…The hypothesis that a non‐coupled alternative oxidase of plant mitochondria operates as an antioxygen defence mechanism [Purvis, A.C. and Shewfelt, R.L.,…”
Get full text

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism by Khomutov, A. R, Keinanen, T. A, Grigorenko, N. A, Hyvonen, M. T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A. R, Khomutov, M. A, Vepsalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine…”
Get full text

Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase by Grigorenko, N. A., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was…”
Get full text

Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus by Korovina, A. N., Tunitskaya, V. L., Khomutov, M. A., Simonian, A. R., Khomutov, A. R., Ivanov, A. V., Kochetkov, S. N.

“…Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV)…”
Get full text

Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase by Khomutov, M. A., Simonian, A. R., Weisell, J., Vepsalainen, J., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown hydroxylamine-containing analogues of 1-guanidino-7-aminohepane (GC7) containing the free aminooxy group (1-aminooxy-6-guanidinohexane),…”
Get full text

Inhibition of agmatine transport in liver mitochondria by new charge-deficient agmatine analogues by Grillo, M A, Battaglia, V, Colombatto, S, Rossi, C A, Simonian, A R, Salvi, M, Khomutov, A R, Toninello, A

“…The charge of the agmatine analogues AO-Agm [N-(3-aminooxypropyl)guanidine], GAPA [N-(3-aminopropoxy)guanidine] and NGPG [N-(3-guanidinopropoxy)guanidine] is…”
Get more information

Leishmania donovani: Structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamines by Mandal, S., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Madhubala, R.

“…The ability of α-, ν-, γ- and ω-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and…”
Get full text

Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism by Khomutov, A R, Keinanen, T A, Grigorenko, N A, Hyvonen, M T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A R, Khomutov, M A, Verspalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the…”
Get more information

Thyroxine induces cyclosporin A‐insensitive, Ca2+‐dependent reversible permeability transition pore in rat liver mitochondria by Malkevitch, N.V, Dedukhova, V.I, Simonian, R.A, Skulachev, V.P, Starkov, A.A

“…The effect of thyroxine on Ca2+‐dependent mitochondrial permeability transition has been examined. It is shown that 40 μM thyroxine induces high amplitude…”
Get full text

Novel agmatine analogue, g-guanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels by Singh, S, Jhingran, A, Sharma, A, Simonian, A R, Soininen, P, Vepsalainen, J, Khomutov, A R, Madhubala, R

“…The efficacy of g-guanidinooxypropylamine (GAPA), a novel agmatine analogue against protozoan parasite, Leishmaniadonovani was evaluated. Wild-type and…”
Get full text

Novel metabolically stable and functionally active mimetic of spermidine by Khomutov, M. A., Hyvönen, M. T., Simonian, A. R., Vepsäläinen, J., Alhonen, L., Kochetkov, S. N., Keinänen, T. A.

“…Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase…”
Get full text

Novel metabolically stable functionally-active mimetic of spermidine by Khomutov, M A, Khivonen, M T, Simonian, A R, Vepsäläinen, Ĭ, Alkhonen, L, Kochetkov, S N, Keinänen, T A

“…Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine…”
Get more information

Aminooxy analogues of spermine and their monoacetyl derivatives by Simonian, A R, Vespalainen, J, Khomutov, A R

“…Convenient methods of synthesis of 1-aminooxy-3,8-diaza-11-aminoundecane, its earlier unknown N1-and N1 -acetyl derivatives, and also…”
Get more information

Uncoupling effect of lauryl sulfate on mitochondria can be mediated by release of bound endogenous fatty acids by Simonian, R A, Pustovidko, A V, Vyssokikh, M Iu, Skulachev, V P

“…The mechanism of uncoupling by lauryl sulfate (LS) has been studied. The very fact that uncoupling by low concentration of LS (a strong acid) resembles very…”
Get full text

New charge-deficient agmatine analogs by Simonian, A R, Grigorenko, N A, Vepsalainen, J, Khomutov, A R

“…N,N'-Di-Boc-N"-triflylguanidine was demonstrated to be an efficient guanidinylation reagent for O-substituted hydroxylamines. N-(3-Aminooxypropyl)- and…”
Get more information

Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives by Ivanov, A V, Simonian, A R, Belanov, E F, Aleksandrova, L A

“…New 5-azole- and 5-oxime-substituted analogues of 2'-deoxyuridine are synthesized. The analogues with azole ring manifest low toxicities and antiherpetic…”
Get more information

New oxaanalogues of spermine by Khomutov, A R, Simonian, A R, Vespalainen, J, Keinanen, T A, Alhonen, L, Janne, J

“…A new isosteric charge-deficient spermine analogue, 1,12-diamino-4,9-diaza-5-oxadodecan, and O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal, a stable analogue…”
Get more information

Coupling effect of 6-ketocholestanol on mitochondria, hydrolyzing adenosine triphosphate in the presence of uncoupling agents-protonophores by Mansurova, S E, Simonian, R A, Skulachev, V P, Starkov, A A

Get more information

Alpha-ketoglutarate carboxylation in brain and liver subcellular fractions of the hen during ontogeny by Arutiunian, L A, Simonian, R A, Movsesian, N O, Simonian, A A

“…Studies have been made of the role of NADPH and NADH in carboxylation of alpha-ketoglutarate to isocytrate in the cytoplasm and mitochondria of the brain and…”
Get more information