Search Results - "Simonian, N A"

Eight-year follow-up study of brain atrophy in patients with MS by FISHER, E, RUDICK, R. A, SIMONIAN, N. A, SIMON, J. H, CUTTER, G, BAIER, M, LEE, J.-C, MILLER, D, WEINSTOCK-GUTTMAN, B, MASS, M. K, DOUGHERTY, D. S

“…To characterize whole-brain atrophy in relapsing-remitting MS (RRMS) patients over an 8-year period. The specific goals of this study were to determine if…”
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Oxidative stress in neurodegenerative diseases by Simonian, N A, Coyle, J T

“…Oxidative stress refers to the cytopathologic consequences of a mismatch between the production of free radicals and the ability of the cell to defend against…”
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Use of the multiple sclerosis Functional Composite to predict disability in relapsing MS by RUDICK, R. A, CUTTER, G, BAIER, M, FISHER, E, DOUGHERTY, D, WEINSTOCK-GUTTMAN, B, MASS, M. K, MILLER, D, SIMONIAN, N. A

“…To determine whether the MS Functional Composite (MSFC) can predict future disease progression in patients with relapsing remitting MS (RR-MS). The MSFC was…”
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Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis by RUDICK, R. A, SIMONIAN, N. A, MASS, M. K, RICHERT, J. R, SALAZAR, A. M, MUNSCHBAUER, F. E, COOKFAIR, D. L, SIMON, J. H, JACOBS, L. D, ALAM, J. A, CAMPION, M, SCARAMUCCI, J. O, JONES, W, COATS, M. E, GOODKIN, D. E, WEINSTOCK-GUTTMAN, B, HERNDON, R. M

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Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage by AKOPOV, S. E, SIMONIAN, N. A, GRIGORIAN, G. S

“…This study was performed to study the dynamics of polymorphonuclear leukocyte (PMNL) accumulation in human cerebral infarction and its association with…”
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Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients by Fisher, E., Rudick, R.A., Cutter, G., Baier, M., Miller, D., Weinstock-Guttman, B., Mass, M.K., Dougherty, D.S., Simonian, N.A.

“…Brain atrophy measurement can provide an estimate of the amount of tissue destruction due to the pathologic processes in multiple sclerosis. The potential…”
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Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis by RUDICK, R. A, GOODKIN, D. E, ALAM, J. J, SIMONIAN, N. A, CAMPION, M. K, BARTOSZAK, D. M, BOURDETTE, D. N, BRAIMAN, J, BROWNSCHEIDLE, C. M, COATS, M. E, COHAN, S. L, DOUGHERTY, D. S, JACOBS, L. D, KINKEL, R. P, MASS, M. K, MUNSCHAUER, F. E, PRIORE, R. L, PULLICINO, P. M, SCHEROKMAN, B. J, WEISTOCK-GUTTMAN, B, WHITHAM, R. H, COOKFAIR, D. L, HERNDON, R. M, RICHERT, J. R, SALAZAR, A. M, FISCHER, J. S, GRANGER, C. V, SIMON, J. H

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Benefit of interferon β-1a on MSFC progression in secondary progressive MS by COHEN, J. A, CUTTER, G. R, TSAO, E. C, WHITAKER, J. N, FISCHER, J. S, GOODMAN, A. D, HEIDENREICH, F. R, KOOIJMANS, M. F, SANDROCK, A. W, RUDICK, R. A, SIMON, J. H, SIMONIAN, N. A

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Kainic acid induces apoptosis in neurons by Simonian, N.A, Getz, R.L, Leveque, J.C, Konradi, C, Coyle, J.T

“…Growing evidence suggests that non- N-methyl- d-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases…”
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Kainate induces apoptosis in neurons by Simonian, N.A, Getz, R.L, Leveque, J.C, Konradi, C, Coyle, J.T

“…Growing evidence suggests that non- N-methyl- d-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases…”
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Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation by Simonian, N A, Hyman, B T

“…The activity of cytochrome oxidase (CO), the terminal enzyme of the electron transport chain, has been reported to be decreased in the brains of individuals…”
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Benefit of interferon beta-1a on MSFC progression in secondary progressive MS by Cohen, J A, Cutter, G R, Fischer, J S, Goodman, A D, Heidenreich, F R, Kooijmans, M F, Sandrock, A W, Rudick, R A, Simon, J H, Simonian, N A, Tsao, E C, Whitaker, J N

“…Interferon beta-1a (IFNbeta-1a, Avonex) is efficacious in relapsing forms of MS. Studies of other IFNbeta preparations in secondary progressive MS (SPMS)…”
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Functional alterations in Alzheimer's disease: decreased glucose transporter 3 immunoreactivity in the perforant pathway terminal zone by Harr, S D, Simonian, N A, Hyman, B T

“…Positron emission tomography (PET) studies measuring glucose utilization have demonstrated cerebral hypometabolism in Alzheimer's disease (AD). The anatomic…”
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Functional alterations in Alzheimer's disease: diminution of cytochrome oxidase in the hippocampal formation by Simonian, N A, Hyman, B T

“…In Alzheimer's disease, the relationship between structural alterations such as neurofibrillary tangles and senile plaques and neuronal function is unknown…”
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Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons by Simonian, N A, Elvhage, T, Czernik, A J, Greengard, P, Hyman, B T

“…Alterations in protein phosphorylation may be important in the pathogenesis of Alzheimer's disease and recent observations suggest that a subset of protein…”
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“Summary measure” statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis by SIMONIAN, NANCY A, MCALLISTER, ARTHUR, LULL, JULIA

“…From a clinical perspective, the question should be raised, "Do we want to consider the disability of these patients to be the same by using the AUC summary…”
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Comparison of Isradipine and Enalapril Effects on Regional Carotid Circulation in Patients with Hypertension with Unilateral Internal Carotid Artery Stenosis by Akopov, Sergey E, Simonian, Nune A

“…This randomized, double-blind, placebo-controlled study was aimed at detecting cerebrovascular effects of isradipine and enalapril in patients with moderate…”
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Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis: Multiple sclerosis by RUDICK, R. A, GOODKIN, D. E, ALAM, J. J, SIMONIAN, N. A, CAMPION, M. K, BARTOSZAK, D. M, BOURDETTE, D. N, BRAIMAN, J, BROWNSCHEIDLE, C. M, COATS, M. E, COHAN, S. L, DOUGHERTY, D. S, JACOBS, L. D, KINKEL, R. P, MASS, M. K, MUNSCHAUER, F. E, PRIORE, R. L, PULLICINO, P. M, SCHEROKMAN, B. J, WEISTOCK-GUTTMAN, B, WHITHAM, R. H, COOKFAIR, D. L, HERNDON, R. M, RICHERT, J. R, SALAZAR, A. M, FISCHER, J. S, GRANGER, C. V, SIMON, J. H

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Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients by Fisher, E, Rudick, R A, Cutter, G, Baier, M, Miller, D, Weinstock-Guttman, B, Mass, M K, Dougherty, D S, Simonian, N A

“…Brain atrophy measurement can provide an estimate of the amount of tissue destruction due to the pathologic processes in multiple sclerosis. The potential…”
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Functional alterations in neural circuits in Alzheimer's disease by Simonian, Nancy A., Hyman, Bradley T.

“…While a correlation exists at the regional level between the distribution of neurofibrillary tangles and the predicted sites of brain dysfunction based on…”
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