Search Results - "Simoni‐Nieves, Arturo"

Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis by Domínguez‐Pérez, Mayra, Simoni‐Nieves, Arturo, Rosales, Patricia, Nuño‐Lámbarri, Natalia, Rosas‐Lemus, Mónica, Souza, Verónica, Miranda, Roxana U., Bucio, Leticia, Uribe Carvajal, Salvador, Marquardt, Jens U., Seo, Daekwan, Gomez‐Quiroz, Luis E., Gutiérrez‐Ruiz, María Concepción

“…Non‐alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of histopathological changes ranging from non‐inflammatory intracellular fat deposition…”
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GDF11 restricts aberrant lipogenesis and changes in mitochondrial structure and function in human hepatocellular carcinoma cells by Hernandez, Sharik, Simoni‐Nieves, Arturo, Gerardo‐Ramírez, Monserrat, Torres, Sandra, Fucho, Raquel, Gonzalez, Jonathan, Castellanos‐Tapia, Lyssia, Hernández‐Pando, Rogelio, Tejero‐Barrera, Elizabeth, Bucio, Leticia, Souza, Verónica, Miranda‐Labra, Roxana, Fernández‐Checa, José C., Marquardt, Jens U., Gomez‐Quiroz, Luis E., García‐Ruiz, Carmen, Gutiérrez‐Ruiz, María C.

“…Growth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features. Recently, it has…”
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Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease by Rastovic, Una, Bozzano, Sergio Francesco, Riva, Antonio, Simoni-Nieves, Arturo, Harris, Nicola, Miquel, Rosa, Lackner, Carolin, Zen, Yoh, Zamalloa, Ane, Menon, Krishna, Heaton, Nigel, Chokshi, Shilpa, Palma, Elena

“…Alcohol-related liver disease (ALD) encompasses a range of pathological conditions that are complex to study at the clinical and preclinical levels. Despite…”
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Mechanism of cholangiocellular damage and repair during cholestasis by Salas-Silva, Soraya, Simoni-Nieves, Arturo, Chávez-Rodríguez, Lisette, Gutiérrez-Ruiz, María Concepción, Bucio, Leticia, Quiroz, Luis E. Gomez

“…The mechanism of damage of the biliary epithelium remains partially unexplored. However, recently many works have offered new evidence regarding the…”
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GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies by Simoni-Nieves, Arturo, Gerardo-Ramírez, Monserrat, Pedraza-Vázquez, Gibrán, Chávez-Rodríguez, Lisette, Bucio, Leticia, Souza, Verónica, Miranda-Labra, Roxana U., Gomez-Quiroz, Luis E., Gutiérrez-Ruiz, María Concepción

“…Growth Differentiation Factor 11 (GDF11), a member of the super family of the Transforming Growth Factor β, has gained more attention in the last few years due…”
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Relevance of Membrane Contact Sites in Cancer Progression by Gil-Hernández, Aurora, Arroyo-Campuzano, Miguel, Simoni-Nieves, Arturo, Zazueta, Cecilia, Gomez-Quiroz, Luis Enrique, Silva-Palacios, Alejandro

“…Membrane contact sites (MCS) are typically defined as areas of proximity between heterologous or homologous membranes characterized by specific proteins. The…”
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HGF/c-Met regulates p22phox subunit of the NADPH oxidase complex in primary mouse hepatocytes by transcriptional and post-translational mechanisms by Simoni-Nieves, Arturo, Clavijo-Cornejo, Denise, Salas-Silva, Soraya, Escobedo-Calvario, Alejandro, Bucio, Leticia, Souza, Verónica, Gutiérrez-Ruiz, María Concepción, Miranda-Labra, Roxana U., Gomez-Quiroz, Luis E.

“…It is well-known that signaling mediated by the hepatocyte growth factor (HGF) and its receptor c-Met in the liver is involved in the control of cellular redox…”
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib by Simoni-Nieves, Arturo, Lindzen, Moshit, Giri, Suvendu, Gupta, Nitin, Chatterjee, Rishita, Selvadurai, Boobash-Raj, Van Daele, Marieke, Love, Danielle, Haga, Yuya, Romaniello, Donatella, Salame, Tomer-Meir, Zerbib, Mirie, Oren, Roni, Tsutsumi, Yasuo, Lauriola, Mattia, Marrocco, Ilaria, Yarden, Yosef

“…Activating EGFR (epidermal growth factor receptor) mutations can be inhibited by specific tyrosine kinase inhibitors (TKIs), which have changed the landscape…”
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Mediterranean-like mix of fatty acids induces cellular protection on lipid-overloaded hepatocytes from western diet fed mice by Castellanos-Tapia, Lyssia, Tejero-Barrera, María Elizabeth, Salas-Silva, Soraya, Simoni-Nieves, Arturo, Escobedo-Calvario, Alejandro, Gomez-Quiroz, Luis E.

“…Introduction and objective. Non-alcoholic fatty liver disease remains as one of the main liver disorders worldwide. It is widely accepted that is the kind of…”
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Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma by Alejandro Escobedo-Calvario, Lisette Chávez-Rodríguez, Arturo Simoni-Nieves, Verónica Souza-Arroyo, Roxana U. Miranda-Labra, Luis E. Gomez-Quiroz, María Concepción Gutiérrez-Ruíz

“…Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol,…”
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AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer by Noronha, Ashish, Belugali Nataraj, Nishanth, Lee, Joo Sang, Zhitomirsky, Benny, Oren, Yaara, Oster, Sara, Lindzen, Moshit, Mukherjee, Saptaparna, Will, Rainer, Ghosh, Soma, Simoni-Nieves, Arturo, Verma, Aakanksha, Chatterjee, Rishita, Borgoni, Simone, Robinson, Welles, Sinha, Sanju, Brandis, Alexander, Kerr, D Lucas, Wu, Wei, Sekar, Arunachalam, Giri, Suvendu, Chung, Youngmin, Drago-Garcia, Diana, Danysh, Brian P, Lauriola, Mattia, Fiorentino, Michelangelo, Ardizzoni, Andrea, Oren, Moshe, Blakely, Collin M, Ezike, Jideofor, Wiemann, Stefan, Parida, Laxmi, Bivona, Trever G, Aqeilan, Rami I, Brugge, Joan S, Regev, Aviv, Getz, Gad, Ruppin, Eytan, Yarden, Yosef

“…Anticancer therapies have been limited by the emergence of mutations and other adaptations. In bacteria, antibiotics activate the SOS response, which mobilizes…”
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Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells by Diaz-Aragon, Ricardo, Ramirez-Ricardo, Javier, Cortes-Reynosa, Pedro, Simoni-Nieves, Arturo, Gomez-Quiroz, Luis-Enrique, Perez Salazar, Eduardo

“…Linoleic acid (LA) is an essential and omega-6 polyunsaturated fatty acid that mediates a variety of biological processes, including migration and invasion in…”
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HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress by Salas-Silva, Soraya, Simoni-Nieves, Arturo, Razori, María Valeria, López-Ramirez, Jocelyn, Barrera-Chimal, Jonatan, Lazzarini, Roberto, Bello, Oscar, Souza, Verónica, Miranda-Labra, Roxana U., Gutiérrez-Ruiz, María Concepción, Gomez-Quiroz, Luis Enrique, Roma, Marcelo G., Bucio-Ortiz, Leticia

“…[Display omitted] Cholestasis is a clinical syndrome common to a large number of hepatopathies, in which either bile production or its transit through the…”
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Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies by Salas-Silva, Soraya, Simoni-Nieves, Arturo, Lopez-Ramirez, Jocelyn, Bucio, Leticia, Gómez-Quiroz, Luis E., Gutiérrez-Ruiz, María Concepción, Roma, Marcelo G.

“…Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially…”
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GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion by Gerardo-Ramírez, Monserrat, Lazzarini-Lechuga, Roberto, Hernández-Rizo, Sharik, Jiménez-Salazar, Javier Esteban, Simoni-Nieves, Arturo, García-Ruiz, Carmen, Fernández-Checa, José Carlos, Marquardt, Jens U., Coulouarn, Cedric, Gutiérrez-Ruiz, María Concepción, Pérez-Aguilar, Benjamín, Gomez-Quiroz, Luis E.

“…Growth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features, despite some…”
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Hepatocyte growth factor reverses cholemic nephropathy associated with α-naphthylisothiocyanate-induced cholestasis in mice by Salas-Silva, Soraya, López-Ramirez, Jocelyn, Barrera-Chimal, Jonatan, Lazzarini-Lechuga, Roberto, Simoni-Nieves, Arturo, Souza, Verónica, Miranda-Labra, Roxana U., Masso, Felipe, Roma, Marcelo G., Gutiérrez-Ruiz, María Concepción, Bucio-Ortiz, Leticia, Gomez-Quiroz, Luis E.

“…Hepatocyte growth factor (HGF) has been proved to protect the liver against α-naphthylisothiocyanate (ANIT)-induced cholestasis by acting as an antioxidant…”
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HGF/c-Met regulates p22 phox subunit of the NADPH oxidase complex in primary mouse hepatocytes by transcriptional and post-translational mechanisms by Simoni-Nieves, Arturo, Clavijo-Cornejo, Denise, Salas-Silva, Soraya, Escobedo-Calvario, Alejandro, Bucio, Leticia, Souza, Verónica, Gutiérrez-Ruiz, María Concepción, Miranda-Labra, Roxana U, Gomez-Quiroz, Luis E

“…It is well-known that signaling mediated by the hepatocyte growth factor (HGF) and its receptor c-Met in the liver is involved in the control of cellular redox…”
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FRI-091-HGF protector effect in intrahepatic cholestasis by Silva, Elsy Soraya Salas, Nieves, Arturo Simoni, Razori, Maria Valeria, Chimal, Jonatan Barrera, Ramírez, Jocelyn López, Bucio-Ortiz, Leticia, Quiroz, Luis Enrique Gómez, Roma, Marcelo Gabriel, Ruiz, María Concepción Gutiérrez

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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab by Marrocco, Ilaria, Giri, Suvendu, Simoni-Nieves, Arturo, Gupta, Nitin, Rudnitsky, Anna, Haga, Yuya, Romaniello, Donatella, Sekar, Arunachalam, Zerbib, Mirie, Oren, Roni, Lindzen, Moshit, Fard, Damon, Tsutsumi, Yasuo, Lauriola, Mattia, Tamagnone, Luca, Yarden, Yosef

“…EGFR-specific tyrosine kinase inhibitors (TKIs), especially osimertinib, have changed lung cancer therapy, but secondary mutations confer drug resistance…”
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Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis by Enríquez-Cortina, Cristina, Bello-Monroy, Oscar, Rosales-Cruz, Patricia, Souza, Verónica, Miranda, Roxana U, Toledo-Pérez, Rafael, Luna-López, Armando, Simoni-Nieves, Arturo, Hernández-Pando, Rogelio, Gutiérrez-Ruiz, María Concepción, Calvisi, Diego F, Marquardt, Jens U, Bucio, Leticia, Gomez-Quiroz, Luis Enrique

“…Primary liver cancers represent the second leading cause of cancer-related deaths worldwide. Diverse etiological factors include chronic viral hepatitis,…”
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