Search Results - "Simoni, Maria Grazia"

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice by Fumagalli, Stefano, Perego, Carlo, Ortolano, Fabrizio, De Simoni, Maria-Grazia

“…The studies on fractalkine and its unique receptor CX3CR1 in neurological disorders yielded contrasting results. We have explored the consequences of CX3CR1…”
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Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice by Perego, Carlo, Fumagalli, Stefano, De Simoni, Maria-Grazia

“…Emerging evidence indicates that, similarly to what happens for peripheral macrophages, microglia can express different phenotypes depending on…”
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Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury by Perego, Carlo, Fumagalli, Stefano, Zanier, Elisa R, Carlino, Erika, Panini, Nicolò, Erba, Eugenio, de Simoni, Maria-Grazia, PhD

“…Abstract Resident microglia and recruited macrophages are major contributors to the post-ischemic inflammatory response. Initially considered functionally…”
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Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma by Zanier, Elisa R., Pischiutta, Francesca, Riganti, Loredana, Marchesi, Federica, Turola, Elena, Fumagalli, Stefano, Perego, Carlo, Parotto, Emanuela, Vinci, Paola, Veglianese, Pietro, D’Amico, Giovanna, Verderio, Claudia, De Simoni, Maria-Grazia

“…Microglia/macrophages (M) are major contributors to postinjury inflammation, but they may also promote brain repair in response to specific environmental…”
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Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis by Orsini, Franca, De Blasio, Daiana, Zangari, Rosalia, Zanier, Elisa R, De Simoni, Maria-Grazia

“…The immune response after brain injury is highly complex and involves both local and systemic events at the cellular and molecular level. It is associated to a…”
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Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy by Filipe, Anne, Chernorudskiy, Alexander, Arbogast, Sandrine, Varone, Ersilia, Villar-Quiles, Rocío-Nur, Pozzer, Diego, Moulin, Maryline, Fumagalli, Stefano, Cabet, Eva, Dudhal, Swati, De Simoni, Maria-Grazia, Denis, Raphaël, Vadrot, Nathalie, Dill, Corinne, Giovarelli, Matteo, Szweda, Luke, De Palma, Clara, Pinton, Paolo, Giorgi, Carlotta, Viscomi, Carlo, Clementi, Emilio, Missiroli, Sonia, Boncompagni, Simona, Zito, Ester, Ferreiro, Ana

“…SEPN1-related myopathy (SEPN1-RM) is a muscle disorder due to mutations of the SEPN1 gene, which is characterized by muscle weakness and fatigue leading to…”
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Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury by Neglia, Laura, Oggioni, Marco, Mercurio, Domenico, De Simoni, Maria-Grazia, Fumagalli, Stefano

“…Mannose-binding lectin (MBL), an initiator of the lectin pathway (LP) of complement activation, is detrimental in ischemic stroke, as shown in clinical studies…”
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A close look at brain dynamics: cells and vessels seen by in vivo two-photon microscopy by Fumagalli, Stefano, Ortolano, Fabrizio, De Simoni, Maria-Grazia

“…The cerebral vasculature has a unique role in providing a constant supply of oxygen and nutrients to ensure normal brain functions. Blood vessels that feed the…”
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Long pentraxin PTX3 is upregulated systemically and centrally after experimental neurotrauma, but its depletion leaves unaltered sensorimotor deficits or histopathology by Oggioni, Marco, Mercurio, Domenico, Minuta, Denise, Fumagalli, Stefano, Popiolek-Barczyk, Katarzyna, Sironi, Marina, Ciechanowska, Agata, Ippati, Stefania, De Blasio, Daiana, Perego, Carlo, Mika, Joanna, Garlanda, Cecilia, De Simoni, Maria-Grazia

“…Long pentraxin PTX3, a pattern recognition molecule involved in innate immune responses, is upregulated by pro-inflammatory stimuli, contributors to secondary…”
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Induction of a transmissible tau pathology by traumatic brain injury by Zanier, Elisa R, Bertani, Ilaria, Sammali, Eliana, Pischiutta, Francesca, Chiaravalloti, Maria Antonietta, Vegliante, Gloria, Masone, Antonio, Corbelli, Alessandro, Smith, Douglas H, Menon, David K, Stocchetti, Nino, Fiordaliso, Fabio, De Simoni, Maria-Grazia, Stewart, William, Chiesa, Roberto

“…See Sastre et al. (doi:10.1093/brain/awy225) for a scientific commentary on this article. Traumatic brain injury (TBI) is a risk factor for subsequent…”
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Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin by Goti, Giulio, Palmioli, Alessandro, Stravalaci, Matteo, Sattin, Sara, De Simoni, Maria-Grazia, Gobbi, Marco, Bernardi, Anna

“…Antagonists of mannose binding lectin (MBL) have shown a protective role against brain reperfusion damage after acute ischemic stroke. Here we describe the…”
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Recombinant C1 inhibitor in brain ischemic injury by Gesuete, Raffaella, Storini, Claudio, Fantin, Alessandro, Stravalaci, Matteo, Zanier, Elisa R., Orsini, Franca, Vietsch, Helene, Mannesse, M. L. Maurice, Ziere, Bertjan, Gobbi, Marco, De Simoni, Maria-Grazia

“…Objective C1 inhibitor (C1‐INH) is an endogenous inhibitor of complement and kinin systems. We have explored the efficacy and the therapeutic window of the…”
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Protein Expression of the Microglial Marker Tmem119 Decreases in Association With Morphological Changes and Location in a Mouse Model of Traumatic Brain Injury by Mercurio, Domenico, Fumagalli, Stefano, Schafer, Martin K-H, Pedragosa, Jordi, Ngassam, Lionel Dejeumen Claude, Wilhelmi, Verena, Winterberg, Sarah, Planas, Anna M, Weihe, Eberhard, De Simoni, Maria-Grazia

“…The activation of microglia and the infiltration of macrophages are hallmarks of neuroinflammation after acute brain injuries, including traumatic brain injury…”
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Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury by Helmy, Adel, De Simoni, Maria-Grazia, Guilfoyle, Mathew R, Carpenter, Keri L H, Hutchinson, Peter J

“…There is an increasing recognition that following traumatic brain injury, a cascade of inflammatory mediators is produced, and contributes to the pathological…”
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CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents by Cipriani, Raffaela, Villa, Pia, Chece, Giuseppina, Lauro, Clotilde, Paladini, Alessandra, Micotti, Edoardo, Perego, Carlo, De Simoni, Maria-Grazia, Fredholm, Bertil B, Eusebi, Fabrizio, Limatola, Cristina

“…The chemokine CX3CL1 and its receptor CX3CR1 are constitutively expressed in the nervous system. In this study, we used in vivo murine models of permanent…”
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Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment by Capone, Carmen, Frigerio, Simona, Fumagalli, Stefano, Gelati, Maurizio, Principato, Maria-Cristina, Storini, Claudio, Montinaro, Mery, Kraftsik, Rudolf, De Curtis, Marco, Parati, Eugenio, De Simoni, Maria-Grazia

“…Neurosphere-derived cells (NC), containing neural stem cells, various progenitors and more differentiated cells, were obtained from newborn C57/BL6 mice and…”
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The phagocytic state of brain myeloid cells after ischemia revealed by superresolution structured illumination microscopy by Fumagalli, Stefano, Fiordaliso, Fabio, Perego, Carlo, Corbelli, Alessandro, Mariani, Alessandro, De Paola, Massimiliano, De Simoni, Maria-Grazia

“…Phagocytosis is a key function of myeloid cells and is highly involved in brain ischemic injury. It has been scarcely studied in vivo, thus preventing a deep…”
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Initiators of Classical and Lectin Complement Pathways Are Differently Engaged after Traumatic Brain Injury-Time-Dependent Changes in the Cortex, Striatum, Thalamus and Hippocampus in a Mouse Model by Ciechanowska, Agata, Ciapała, Katarzyna, Pawlik, Katarzyna, Oggioni, Marco, Mercurio, Domenico, De Simoni, Maria-Grazia, Mika, Joanna

“…The complement system is involved in promoting secondary injury after traumatic brain injury (TBI), but the roles of the classical and lectin pathways leading…”
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Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1 by Orsini, Franca, Chrysanthou, Elvina, Dudler, Thomas, Cummings, W Jason, Takahashi, Minoru, Fujita, Teizo, Demopulos, Gregory, De Simoni, Maria-Grazia, Schwaeble, Wilhelm

“…Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing…”
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Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice by Sammali, Eliana, Alia, Claudia, Vegliante, Gloria, Colombo, Valentina, Giordano, Nadia, Pischiutta, Francesca, Boncoraglio, Giorgio B., Barilani, Mario, Lazzari, Lorenza, Caleo, Matteo, De Simoni, Maria-Grazia, Gaipa, Giuseppe, Citerio, Giuseppe, Zanier, Elisa R.

“…Transplantation of human bone marrow mesenchymal stromal cells (hBM-MSC) promotes functional recovery after stroke in animal models, but the mechanisms…”
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