Search Results - "Simonet, S."

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats by Li, Xiaodong, Warmington, Kelly S, Niu, Qing‐Tian, Asuncion, Franklin J, Barrero, Mauricio, Grisanti, Mario, Dwyer, Denise, Stouch, Brian, Thway, Theingi M, Stolina, Marina, Ominsky, Michael S, Kostenuik, Paul J, Simonet, William S, Paszty, Chris, Ke, Hua Zhu

“…The purpose of this study was to evaluate the effects of sclerostin inhibition by treatment with a sclerostin antibody (Scl‐AbII) on bone formation, bone mass,…”
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Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones by Ominsky, Michael S, Li, Chaoyang, Li, Xiaodong, Tan, Hong L, Lee, Edward, Barrero, Mauricio, Asuncion, Franklin J, Dwyer, Denise, Han, Chun‐Ya, Vlasseros, Fay, Samadfam, Rana, Jolette, Jacquelin, Smith, Susan Y, Stolina, Marina, Lacey, David L, Simonet, William S, Paszty, Chris, Li, Gang, Ke, Hua Z

“…Therapeutic enhancement of fracture healing would help to prevent the occurrence of orthopedic complications such as nonunion and revision surgery. Sclerostin…”
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Gadolinium-Based Nanoparticles Can Overcome the Radioresistance of Head and Neck Squamous Cell Carcinoma Through the Induction of Autophagy by Simonet, S, Rodriguez-Lafrasse, C, Beal, D, Gerbaud, S, Malesys, C, Tillement, O, Lux, F, Fayyad-Kazan, H, Rachidi, W, Ardail, D

“…Radiation therapy is a mainstay in the therapeutic management of Head and Neck Squamous Cell Carcinoma (HNSCC). Despite significant progress in this field,…”
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Generalized Degenerative Joint Disease in Osteoprotegerin (Opg) Null Mutant Mice by Bolon, B., Grisanti, M., Villasenor, K., Morony, S., Feige, U., Simonet, W. S.

“…Bone structure is modulated by the interaction between receptor activator of nuclear factor–κB (RANK) and RANK ligand (RANKL). Osteoprotegerin (OPG), a decoy…”
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RANKL Inhibition with Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular bone Architecture in Ovariectomized Rats by Ominsky, Michael S, Li, Xiaodong, Asuncion, Frank J, Barrero, Mauricio, Warmington, Kelly S, Dwyer, Denise, Stolina, Marina, Geng, Zhaopo, Grisanti, Mario, Tan, Hong‐Lin, Corbin, Timothy, McCabe, James, Simonet, William S, Ke, Hua Z, Kostenuik, Paul J

“…Introduction: Ovariectomy (OVX) results in bone loss caused by increased bone resorption. RANKL is an essential mediator of bone resorption. We examined…”
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HER Family Blockade in Head and Neck Squamous Cell Carcinoma: Couple Therapy Efficacy of Cetuximab and Pertuzumab Combined With Photon Irradiation by Guy, J.B, Méry, B, Rancoule, C, Vallard, A, Espenel, S, Wozny, A.S, Simonet, S, Bernard, D, Ardail, D, Beuve, M, Alphonse, G, Rodriguez-Lafrasse, C, Magné, N

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Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density by Simonet, W.S, Lacey, D.L, Dunstan, C.R, Kelley, M, Chang, M.-S, Lüthy, R, Nguyen, H.Q, Wooden, S, Bennett, L, Boone, T, Shimamoto, G, DeRose, M, Elliott, R, Colombero, A, Tan, H.-L, Trail, G, Sullivan, J, Davy, E, Bucay, N, Renshaw-Gegg, L, Hughes, T.M, Hill, D, Pattison, W, Campbell, P, Sander, S, Van, G, Tarpley, J, Derby, P, Lee, R, Boyle, W.J

“…A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF…”
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Allogeneic Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER): A Phase I Safety Clinical Trial by Glassberg, Marilyn K, Minkiewicz, Julia, Toonkel, Rebecca L, Simonet, Emmanuelle S, Rubio, Gustavo A, DiFede, Darcy, Shafazand, Shirin, Khan, Aisha, Pujol, Marietsy V, LaRussa, Vincent F, Lancaster, Lisa H, Rosen, Glenn D, Fishman, Joel, Mageto, Yolanda N, Mendizabal, Adam, Hare, Joshua M

“…Despite Food and Drug Administration approval of 2 new drugs for idiopathic pulmonary fibrosis (IPF), curative therapies remain elusive and mortality remains…”
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One Year of Transgenic Overexpression of Osteoprotegerin in Rats Suppressed Bone Resorption and Increased Vertebral Bone Volume, Density, and Strength by Ominsky, Michael S, Stolina, Marina, Li, Xiaodong, Corbin, Timothy J, Asuncion, Franklin J, Barrero, Mauricio, Niu, Qing‐Tian, Dwyer, Denise, Adamu, Steven, Warmington, Kelly S, Grisanti, Mario, Tan, Hong L, Ke, Hua Z, Simonet, William S, Kostenuik, Paul J

“…RANKL is an essential mediator of bone resorption, and its activity is inhibited by osteoprotegerin (OPG). Transgenic (Tg) rats were engineered to continuously…”
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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification by Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., Boyle, W. J., Simonet, W. S.

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Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats by Panos, R J, Bak, P M, Simonet, W S, Rubin, J S, Smith, L J

“…Alveolar type II cell proliferation occurs after many forms of lung injury and is thought to play a critical role in alveolar epithelial repair. Keratinocyte…”
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Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock‐In Mice That Express Chimeric (Murine/Human) RANKL by Kostenuik, Paul J, Nguyen, Hung Q, McCabe, James, Warmington, Kelly S, Kurahara, Carol, Sun, Ning, Chen, Ching, Li, Luke, Cattley, Russ C, Van, Gwyneth, Scully, Shelia, Elliott, Robin, Grisanti, Mario, Morony, Sean, Tan, Hong Lin, Asuncion, Frank, Li, Xiaodong, Ominsky, Michael S, Stolina, Marina, Dwyer, Denise, Dougall, William C, Hawkins, Nessa, Boyle, William J, Simonet, William S, Sullivan, John K

“…RANKL is a TNF family member that mediates osteoclast formation, activation, and survival by activating RANK. The proresorptive effects of RANKL are prevented…”
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Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody by Li, Xiaodong, Niu, Qing-Tian, Warmington, Kelly S, Asuncion, Franklin J, Dwyer, Denise, Grisanti, Mario, Han, Chun-Ya, Stolina, Marina, Eschenberg, Michael J, Kostenuik, Paul J, Simonet, William S, Ominsky, Michael S, Ke, Hua Zhu

“…The effects of up to 26 weeks of sclerostin antibody (Scl-Ab) treatment were investigated in ovariectomized (OVX) rats. Two months after surgery, 6-month-old…”
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P10.03: Evaluation of Arterial Stiffness in Atherosclerotic Rabbits in Vivo Via Echotracking by Vayssettes-Courchay, C., Ragonnet, C., Simonet, S., Verbeuren, T. J., Vilaine, J. P.

“…Objectives We have shown that large artery stiffening, a major risk factor in cardiovascular diseases, can be evaluated in hypertensive rats by echotracking,…”
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A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice by SIMONET, W. S, BUCAY, N, LAUER, S. J, TAYLOR, J. M

“…The human apolipoprotein (apo) E and apoC-I genes are located 5 kilobases apart in the same transcriptional orientation on chromosome 19, and they are…”
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Increased Bone Formation and Bone Mass Induced by Sclerostin Antibody Is Not Affected by Pretreatment or Cotreatment with Alendronate in Osteopenic, Ovariectomized Rats by Li, Xiaodong, Ominsky, Michael S, Warmington, Kelly S, Niu, Qing-Tian, Asuncion, Franklin J, Barrero, Mauricio, Dwyer, Denise, Grisanti, Mario, Stolina, Marina, Kostenuik, Paul J, Simonet, William S, Paszty, Chris, Ke, Hua Zhu

“…Clinical studies have revealed a blunting of the bone anabolic effects of parathyroid hormone treatment in osteoporotic patients in the setting of pre- or…”
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Keratinocyte growth factor reduces lung damage due to acid instillation in rats by Yano, T, Deterding, R R, Simonet, W S, Shannon, J M, Mason, R J

“…Acid aspiration is a serious complication of anesthesia and other forms of unconsciousness that can result in the adult respiratory distress syndrome (ARDS),…”
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Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E by DE SILVA, H. V, LAUER, S. J, JAIJING WANG, SIMONET, W. S, WEISGRABER, K. H, MAHLEY, R. W, TAYLOR, J. M

“…Overexpression of human apolipoprotein (apo) C-III in the plasma of transgenic mice results in hypertriglyceridemia, with up to a 20-fold elevation in plasma…”
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Osteoclast differentiation and activation by Boyle, William J, Simonet, W. Scott, Lacey, David L

“…Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and…”
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Pulmonary Malformation in Transgenic Mice Expressing Human Keratinocyte Growth Factor in the Lung by Simonet, W S, DeRose, M L, Bucay, N, Nguyen, H Q, Wert, S E, Zhou, L, Ulich, T R, Thomason, A, Danilenko, D M, Whitsett, J A

“…Expression of human keratinocyte growth factor (KGF/FGF-7) was directed to epithelial cells of the developing embryonic lung of transgenic mice disrupting…”
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