Vascular Effects of Perinatal Hypoxia in the Early Postnatal Period in Rats

Vascular Effects of Perinatal Hypoxia in the Early Postnatal Period in Rats

The normal functioning of the vascular system in early ontogenesis can be altered by adverse exposures affecting the organism of the fetus/newborn during pregnancy, at birth, or in the postpartum period. However, the information on the “acute” (immediately after exposure) and “delayed” (after severa...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology Vol. 59; no. 3; pp. 800 - 808
Main Authors: Shvetsova, A. A., Khukhareva, D. D., Simonenko, S. D., Khlystova, M. A., Borzykh, A. A., Gaynullina, D. K.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-05-2023
Springer Nature B.V
Subjects:
Animal Physiology
Arteries
Biochemistry
Biomedical and Life Sciences
Contractility
Endothelium
Evolutionary Biology
Experimental Papers
Fetuses
Hypoxia
Isometric
Life Sciences
Nitric oxide
Rho-associated kinase
Sympathomimetics
Vascular system
Veins & arteries
Rho-kinase
smooth muscle
hypoxia
endothelium
nitric oxide
artery
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Summary:The normal functioning of the vascular system in early ontogenesis can be altered by adverse exposures affecting the organism of the fetus/newborn during pregnancy, at birth, or in the postpartum period. However, the information on the “acute” (immediately after exposure) and “delayed” (after several days) effects of short-term (within several hours) perinatal normobaric hypoxia on the functioning of the peripheral vascular system of the systemic circulation in early ontogenesis in mammals is quite insufficient. The aim of this work was to study the “acute” and “delayed” single-session effects of a normobaric hypoxic exposure on the functioning of the systemic arteries in early postnatal ontogenesis. The contractile responses of the saphenous arteries in 10–14-day-old rats were studied in isometric mode. Acute normobaric hypoxia (8% O 2 ) was simulated in 10-day-old rat pups for 2 h. The selected hypoxic regimen did not lead to changes in arterial contractile responses to the α 1 -adrenergic agonist methoxamine either immediately after exposure or several days later. Endothelium-dependent relaxation of the arteries to acetylcholine also did not differ between groups. Hypoxia did not change the contribution of anticontractile pathways associated with nitric oxide and Kv7 channels, as well as the procontractile role of Rho-kinase. Thus, short-term normobaric hypoxic exposure on postnatal day 10 leads to neither “acute” nor “delayed” changes in tone regulation of the peripheral arteries of the systemic circulation in the early postnatal period in rats.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093023030134