Search Results - "Simonelli, Luca"

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection by Stettler, Karin, Beltramello, Martina, Espinosa, Diego A., Graham, Victoria, Cassotta, Antonino, Bianchi, Siro, Vanzetta, Fabrizia, Minola, Andrea, Jaconi, Stefano, Mele, Federico, Foglierini, Mathilde, Pedotti, Mattia, Simonelli, Luca, Dowall, Stuart, Atkinson, Barry, Percivalle, Elena, Simmons, Cameron P., Varani, Luca, Blum, Johannes, Baldanti, Fausto, Cameroni, Elisabetta, Hewson, Roger, Harris, Eva, Lanzavecchia, Antonio, Sallusto, Federica, Corti, Davide

“…Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency. By characterizing memory lymphocytes…”
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Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia by Arcangeli, Silvia, Rotiroti, Maria Caterina, Bardelli, Marco, Simonelli, Luca, Magnani, Chiara Francesca, Biondi, Andrea, Biagi, Ettore, Tettamanti, Sarah, Varani, Luca

“…Chimeric antigen receptor (CAR)-redirected T lymphocytes are a promising immunotherapeutic approach and object of pre-clinical evaluation for the treatment of…”
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Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery by Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Cebollero, Eduardo, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria, Galli, Carmela, Loi, Marisa, Soldà, Tatiana, D’Antuono, Rocco, Raimondi, Andrea, Jung, Martin, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne, Simonelli, Luca, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay, Peter, Matthias, Quadroni, Manfredo, Zimmermann, Richard, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the…”
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Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus by Corti, Davide, Zhao, Jincun, Pedotti, Mattia, Simonelli, Luca, Agnihothram, Sudhakar, Fett, Craig, Fernandez-Rodriguez, Blanca, Foglierini, Mathilde, Agatic, Gloria, Vanzetta, Fabrizia, Gopal, Robin, Langrish, Christopher J., Barrett, Nicholas A, Sallusto, Federica, Baric, Ralph S., Varani, Luca, Zambon, Maria, Perlman, Stanley, Lanzavecchia, Antonio

“…Middle East Respiratory Syndrome (MERS) is a highly lethal pulmonary infection caused by a previously unidentified coronavirus (CoV), likely transmitted to…”
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SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface by Bertoglio, Federico, Meier, Doris, Langreder, Nora, Steinke, Stephan, Rand, Ulfert, Simonelli, Luca, Heine, Philip Alexander, Ballmann, Rico, Schneider, Kai-Thomas, Roth, Kristian Daniel Ralph, Ruschig, Maximilian, Riese, Peggy, Eschke, Kathrin, Kim, Yeonsu, Schäckermann, Dorina, Pedotti, Mattia, Kuhn, Philipp, Zock-Emmenthal, Susanne, Wöhrle, Johannes, Kilb, Normann, Herz, Tobias, Becker, Marlies, Grasshoff, Martina, Wenzel, Esther Veronika, Russo, Giulio, Kröger, Andrea, Brunotte, Linda, Ludwig, Stephan, Fühner, Viola, Krämer, Stefan Daniel, Dübel, Stefan, Varani, Luca, Roth, Günter, Čičin-Šain, Luka, Schubert, Maren, Hust, Michael

“…COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a new recently emerged sarbecovirus. This virus uses the human ACE2 enzyme as receptor for…”
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Humoral and cell-mediated response against SARS-CoV-2 variants elicited by mRNA vaccine BNT162b2 in healthcare workers: a longitudinal observational study by Cassaniti, Irene, Bergami, Federica, Percivalle, Elena, Gabanti, Elisa, Sammartino, Josè Camilla, Ferrari, Alessandro, Adzasehoun, Kodjo Messan Guy, Zavaglio, Federica, Zelini, Paola, Comolli, Giuditta, Sarasini, Antonella, Piralla, Antonio, Ricciardi, Alessandra, Zuccaro, Valentina, Maggi, Fabrizio, Novazzi, Federica, Simonelli, Luca, Varani, Luca, Lilleri, Daniele, Baldanti, Fausto

“…To assess the humoral and cell-mediated response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicited by the mRNA BNT162b2 vaccine in…”
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Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer by Guerrini, Giuditta, Mehn, Dora, Fumagalli, Francesco, Gioria, Sabrina, Pedotti, Mattia, Simonelli, Luca, Bianchini, Filippo, Robbiani, Davide F, Varani, Luca, Calzolai, Luigi

“…Analytical ultracentrifugation (AUC) analysis shows that the SARS-CoV-2 trimeric Spike (S) protein adopts different quaternary conformations in solution. The…”
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A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity by Bardelli, Marco, Frontzek, Karl, Simonelli, Luca, Hornemann, Simone, Pedotti, Mattia, Mazzola, Federica, Carta, Manfredi, Eckhardt, Valeria, D'Antuono, Rocco, Virgilio, Tommaso, González, Santiago F, Aguzzi, Adriano, Varani, Luca

“…Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies…”
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Rational engineering of the lccβ T. versicolor laccase for the mediator-less oxidation of large polycyclic aromatic hydrocarbons by Chiadò, Alessandro, Bosco, Francesca, Bardelli, Marco, Simonelli, Luca, Pedotti, Mattia, Marmo, Luca, Varani, Luca

“…[Display omitted] •Computational-assisted protein engineering of the binding pocket of laccases.•Mutants have activity increased up to ~ 300% in a broader pH…”
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Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses by Cervantes Rincón, Tomás, Kapoor, Tania, Keeffe, Jennifer R., Simonelli, Luca, Hoffmann, Hans-Heinrich, Agudelo, Marianna, Jurado, Andrea, Peace, Avery, Lee, Yu E., Gazumyan, Anna, Guidetti, Francesca, Cantergiani, Jasmine, Cena, Benedetta, Bianchini, Filippo, Tamagnini, Elia, Moro, Simone G., Svoboda, Pavel, Costa, Federico, Reis, Mitermayer G., Ko, Albert I., Fallon, Brian A., Avila-Rios, Santiago, Reyes-Téran, Gustavo, Rice, Charles M., Nussenzweig, Michel C., Bjorkman, Pamela J., Ruzek, Daniel, Varani, Luca, MacDonald, Margaret R., Robbiani, Davide F.

“…Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in…”
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Computational docking of antibody-antigen complexes, opportunities and pitfalls illustrated by influenza hemagglutinin by Pedotti, Mattia, Simonelli, Luca, Livoti, Elsa, Varani, Luca

“…Antibodies play an increasingly important role in both basic research and the pharmaceutical industry. Since their efficiency depends, in ultimate analysis, on…”
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Rational engineering of a human anti-dengue antibody through experimentally validated computational docking by Simonelli, Luca, Pedotti, Mattia, Beltramello, Martina, Livoti, Elsa, Calzolai, Luigi, Sallusto, Federica, Lanzavecchia, Antonio, Varani, Luca

“…Antibodies play an increasing pivotal role in both basic research and the biopharmaceutical sector, therefore technology for characterizing and improving their…”
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Adapting Neutralizing Antibodies to Viral Variants by Structure-Guided Affinity Maturation Using Phage Display Technology by Peissert, Frederik, Pedotti, Mattia, Corbellari, Riccardo, Simonelli, Luca, De Gasparo, Raoul, Tamagnini, Elia, Plüss, Louis, Elsayed, Abdullah, Matasci, Mattia, De Luca, Roberto, Cassaniti, Irene, Sammartino, Jose' Camilla, Piralla, Antonio, Baldanti, Fausto, Neri, Dario, Varani, Luca

“…Neutralizing monoclonal antibodies have achieved great efficacy and safety for the treatment of numerous infectious diseases. However, their neutralization…”
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Rational modification of estrogen receptor by combination of computational and experimental analysis by Ferrero, Valentina Elisabetta Viviana, Pedotti, Mattia, Chiadò, Alessandro, Simonelli, Luca, Calzolai, Luigi, Varani, Luca, Lettieri, Teresa

“…In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding…”
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Rapid Structural Characterization of Human Antibody–Antigen Complexes through Experimentally Validated Computational Docking by Simonelli, Luca, Beltramello, Martina, Yudina, Zinaida, Macagno, Annalisa, Calzolai, Luigi, Varani, Luca

“…If we understand the structural rules governing antibody (Ab)–antigen (Ag) interactions in a given virus, then we have the molecular basis to attempt to design…”
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Erratum: Corrigendum: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery by Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Cebollero, Eduardo, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria, Galli, Carmela, Loi, Marisa, Soldà, Tatiana, D'Antuono, Rocco, Raimondi, Andrea, Jung, Martin, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne, Simonelli, Luca, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay, Peter, Matthias, Quadroni, Manfredo, Zimmermann, Richard, Molinari, Maurizio

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Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice by De Gasparo, Raoul, Pedotti, Mattia, Simonelli, Luca, Nickl, Petr, Muecksch, Frauke, Cassaniti, Irene, Percivalle, Elena, Lorenzi, Julio C. C., Mazzola, Federica, Magrì, Davide, Michalcikova, Tereza, Haviernik, Jan, Honig, Vaclav, Mrazkova, Blanka, Polakova, Natalie, Fortova, Andrea, Tureckova, Jolana, Iatsiuk, Veronika, Di Girolamo, Salvatore, Palus, Martin, Zudova, Dagmar, Bednar, Petr, Bukova, Ivana, Bianchini, Filippo, Mehn, Dora, Nencka, Radim, Strakova, Petra, Pavlis, Oto, Rozman, Jan, Gioria, Sabrina, Sammartino, Josè Camilla, Giardina, Federica, Gaiarsa, Stefano, Pan-Hammarström, Qiang, Barnes, Christopher O., Bjorkman, Pamela J., Calzolai, Luigi, Piralla, Antonio, Baldanti, Fausto, Nussenzweig, Michel C., Bieniasz, Paul D., Hatziioannou, Theodora, Prochazka, Jan, Sedlacek, Radislav, Robbiani, Davide F., Ruzek, Daniel, Varani, Luca

“…Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein are among the most promising approaches against COVID-19…”
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A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential by Wang, Jiaqi, Bardelli, Marco, Espinosa, Diego A., Pedotti, Mattia, Ng, Thiam-Seng, Bianchi, Siro, Simonelli, Luca, Lim, Elisa X.Y., Foglierini, Mathilde, Zatta, Fabrizia, Jaconi, Stefano, Beltramello, Martina, Cameroni, Elisabetta, Fibriansah, Guntur, Shi, Jian, Barca, Taylor, Pagani, Isabel, Rubio, Alicia, Broccoli, Vania, Vicenzi, Elisa, Graham, Victoria, Pullan, Steven, Dowall, Stuart, Hewson, Roger, Jurt, Simon, Zerbe, Oliver, Stettler, Karin, Lanzavecchia, Antonio, Sallusto, Federica, Cavalli, Andrea, Harris, Eva, Lok, Shee-Mei, Varani, Luca, Corti, Davide

“…Zika virus (ZIKV), a mosquito-borne flavivirus, causes devastating congenital birth defects. We isolated a human monoclonal antibody (mAb), ZKA190, that…”
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A conformational switch controlling the toxicity of the prion protein by Frontzek, Karl, Bardelli, Marco, Senatore, Assunta, Henzi, Anna, Reimann, Regina R., Bedir, Seden, Marino, Marika, Hussain, Rohanah, Jurt, Simon, Meisl, Georg, Pedotti, Mattia, Mazzola, Federica, Siligardi, Giuliano, Zerbe, Oliver, Losa, Marco, Knowles, Tuomas, Lakkaraju, Asvin, Zhu, Caihong, Schwarz, Petra, Hornemann, Simone, Holt, Matthew G., Simonelli, Luca, Varani, Luca, Aguzzi, Adriano

“…Prion infections cause conformational changes of the cellular prion protein (PrP C ) and lead to progressive neurological impairment. Here we show that toxic,…”
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The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity by Beltramello, Martina, Williams, Katherine L, Simmons, Cameron P, Macagno, Annalisa, Simonelli, Luca, Quyen, Nguyen Than Ha, Sukupolvi-Petty, Soila, Navarro-Sanchez, Erika, Young, Paul R, de Silva, Aravinda M, Rey, Félix A, Varani, Luca, Whitehead, Stephen S, Diamond, Michael S, Harris, Eva, Lanzavecchia, Antonio, Sallusto, Federica

“…Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors…”
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