Search Results - "Simoneau, Anne R"

Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy by Liu, Zhongbo, Li, Xuesen, Simoneau, Anne R., Jafari, Mahtab, Zi, Xiaolin

“…The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and bladder carcinogenesis and a…”
Get full text

Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice by XIAOLIN ZI, SIMONEAU, Anne R

“…Consumption of the traditional kava preparation was reported to correlate with low and uncustomary gender ratios (more cancer in women than men) of cancer…”
Get full text

Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice by Liu, Zhongbo, Song, Liankun, Xie, Jun, Simoneau, Anne R, Uchio, Edward, Zi, Xiaolin

“…Non-muscle-invasive bladder cancer (NMIBC) has one of the highest recurrence rates among all solid cancers and the highest lifetime treatment cost per patient…”
Get full text

Lycopene Enhances Docetaxel's Effect in Castration-Resistant Prostate Cancer Associated with Insulin-like Growth Factor I Receptor Levels by Tang, Yaxiong, Parmakhtiar, Basmina, Simoneau, Anne R, Xie, Jun, Fruehauf, John, Lilly, Michael, Zi, Xiaolin

“…Docetaxel is currently the most effective drug for the treatment of castration-resistant prostate cancer (CRPC), but it only extends life by an average of 2…”
Get full text

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition by Yee, David S, Tang, Yaxiong, Li, Xuesen, Liu, Zhongbo, Guo, Yi, Ghaffar, Samia, McQueen, Peter, Atreya, Dash, Xie, Jun, Simoneau, Anne R, Hoang, Bang H, Zi, Xiaolin

“…Aberrations in the Wnt pathway have been reported to be involved in the metastasis of prostate cancer (PCa) to bone. We investigated the effect and underlying…”
Get full text

Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness by Zi, Xiaolin, Guo, Yi, Simoneau, Anne R, Hope, Christopher, Xie, Jun, Holcombe, Randall F, Hoang, Bang H

“…The ability of Frzb/secreted Frizzled-related protein 3 (sFRP3) to inhibit Wnt signaling and the localization of Frzb/sFRP3 on chromosome 2q to a region…”
Get full text

The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial by Simoneau, Anne R, Gerner, Eugene W, Nagle, Ray, Ziogas, Argyrios, Fujikawa-Brooks, Sharon, Yerushalmi, Hagit, Ahlering, Thomas E, Lieberman, Ronald, McLaren, Christine E, Anton-Culver, Hoda, Meyskens, Jr, Frank L

“…Background: Prostate cancer is a major health issue, and prevention of prostate cancer and/or its progression will yield benefits for men…”
Get full text

Flavokawain B, a kava chalcone, induces apoptosis via up‐regulation of death‐receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth by Tang, Yaxiong, Li, Xuesen, Liu, Zhongbo, Simoneau, Anne R., Xie, Jun, Zi, Xiaolin

“…Limited success has been achieved in extending the survival of patients with metastatic and hormone‐refractory prostate cancer (HRPC). There is a strong need…”
Get full text

Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53 by Tang, Yaxiong, Simoneau, Anne R, Xie, Jun, Shahandeh, Babbak, Zi, Xiaolin

“…Flavokawain A is the predominant chalcone from kava extract. We have assessed the mechanisms of flavokawain A's action on cell cycle regulation. In a p53…”
Get full text

WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells by Tang, Yaxiong, Simoneau, Anne R, Liao, Wu-xiang, Yi, Guo, Hope, Christopher, Liu, Feng, Li, Shunqiang, Xie, Jun, Holcombe, Randall F, Jurnak, Frances A, Mercola, Dan, Hoang, Bang H, Zi, Xiaolin

“…Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and with invasive bladder cancer…”
Get full text

KAVA Chalcone, Flavokawain A, Inhibits Urothelial Tumorigenesis in the UPII-SV40T Transgenic Mouse Model by ZHONGBO LIU, XIA XU, XUESEN LI, SHUMAN LIU, SIMONEAU, Anne R, FENG HE, WU, Xue-Ru, XIAOLIN ZI

“…Flavokawain A (FKA) is the predominant chalcone identified from the kava plant. We have previously shown that FKA preferentially inhibits the growth of p53…”
Get full text

Chemoprevention of prostate cancer with the polyamine synthesis inhibitor difluoromethylornithine by Meyskens, Jr, Frank L, Simoneau, Anne R, Gerner, Eugene W

“…In vitro and in vivo preclinical results suggest that inhibition of polyamine synthesis inhibits the progression of prostate cancer. These findings has led to…”
Get more information

Three-Dimensional Sonography With Needle Tracking: Role in Diagnosis and Treatment of Prostate Cancer by Shen, Feimo, Shinohara, Katsuto, Kumar, Dinesh, Khemka, Animesh, Simoneau, Anne R, Werahera, Priya N, Li, Lu, Guo, Yujun, Narayanan, Ramkrishnan, Wei, Liyang, Barqawi, Al, Crawford, E. David, Davatzikos, Christos, Suri, Jasjit S

“…Image-guided prostate biopsy has become routine in medical diagnosis. Although it improves biopsy outcome, it mostly operates in 2 dimensions, therefore…”
Get full text

Continent lower urinary tract reconstruction in the cervical spinal cord injured population by Zommick, Jason N, Simoneau, Anne R, Skinner, Donald G, Ginsberg, David A

“…Patients with cervical spinal cord injury and upper extremity dysfunction are treated primarily with indwelling or condom catheters. We present our experience…”
Get more information

P16 gene in uncultured tumours by Spruck, Charles H, Gonzalez-Zulueta, Mirella, Shibata, Atsuko, Simoneau, Anne R, Lin, Ming-Fong, Gonzales, Felicidad, Tsai, Yvonne C, Jones, Peter A

Get full text

α-Difluoromethylornithine and Polyamine Levels in the Human Prostate: Results of a Phase IIa Trial by Simoneau, Anne R., Gerner, Eugene W., Phung, Mai, McLaren, Christine E., Meyskens, Frank L.

“…Fig. 1 compares the absolute values of putrescine, spermidine, spermine, and the spermidine/spermine ratio before and after DFMO treatment. Pretherapy…”
Get full text

Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations by SIMONEAU, A. R, SPRUCK, C. H, GONZALEZ-ZULUETA, M, GONZALGO, M. L, CHAN, M. F, TSAI, Y. C, DEAN, M, STEVEN, K, HORN, T, JONES, P. A

“…The most common genetic alteration identified to date in bladder cancer is loss of heterozygosity (LOH) of chromosome 9, suggesting the presence of possible…”
Get full text

Abstract 618: Rhodiola rosea L . extract, SHR-5, and metformin exhibit potent activity against bladder carcinogenesis in the UPII-mutant Ha-ras transgenic model by Liu, Zhongbo, Li, Xuesen, Liu, Shuman, Xu, Xia, Tian, Xuejiao, Simoneau, Anne R., Zi, Xiaolin

“…Abstract The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and bladder…”
Get full text

Abstract 5681: Flavokawain B down-regulates SKP2 through a proteasome-dependent and ubiquitin-independent pathway, and acts synergistically with Bortezomib on inhibition of Skp2 expression and prostate cancer cell growth by Li, Xuesen, Liu, Zhongbo, Simoneau, Anne R., Zi, Xiaolin

“…Abstract The E3 ubiquitin ligase SKP2 (S-phase kinase-associated protein 2), an oncogenic protein, was found to be overexpressed in 557 of 622 (89.2%) primary…”
Get full text

Abstract 619: Flavokawain A inhibits urinary bladder carcinogenesis in the UPII-SV40T transgenic mouse bladder cancer model by Liu, Zhongbo, Li, Xuesen, liu, Shuman, Xu, Xia, Tian, Xuejiao, Simoneau, Anne R., Wu, Xue-Ru, Zi, Xiaolin

“…Abstract The UPII-SV40T transgenic model of the mouse bladder reproduces a precursor to recurrent and invasive Transitional Cell Carcinoma (TCC): carcinoma in…”
Get full text