Search Results - "Simone Michaela Simons"

A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system by Chudzinski-Tavassi, Ana Marisa, De-Sá-Júnior, Paulo Luis, Simons, Simone Michaela, Maria, Durvanei Augusto, de Souza Ventura, Janaina, de Fátima Correia Batista, Isabel, Faria, Fernanda, Durães, Esther, Reis, Eduardo Moraes, Demasi, Marilene

“…The aim of this study was to evaluate the anti-tumor activity of Amblyomin-X, a serine protease Kunitz-type inhibitor. Amblyomin-X induced tumor mass…”
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Corrigendum to “Pro-apoptotic effects of Amblyomin-X in murine renal cell carcinoma “in vitro” [Biomed. Pharmacother. 66 (2012) 64–69] by Akagi, Erica Mie, de Sá Júnior, Paulo Luiz, Simons, Simone Michaela, Bellini, Maria Helena, Barreto, Sandra Alves, Chudzinski-Tavassi, Ana Marisa

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Antiproliferative and antiangiogenic effect of Amblyomma sculptum (Acari: Ixodidae) crude saliva in endothelial cells in vitro by de Sá Junior, Paulo Luiz, Dias Câmara, Diana Aparecida, Sciani, Juliana Mozer, Porcacchia, Allan Saj, Moreira Fonseca, Pâmela Maria, Mendonça, Ronaldo Zucatelli, Elifio-Esposito, Selene, Simons, Simone Michaela

“…•CS consists of a panacea of biomolecules that perform innumerable functions when inoculated in the host during blood feeding.•Depending on its concentration…”
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Artificial Feeding of Ornithodoros fonsecai and O. brasiliensis (Acari: Argasidae) and Investigation of the Transstadial Perpetuation of Anaplasma marginale by Castro-Santiago, Ana Carolina, Lima-Duarte, Leidiane, Camargo, Jaqueline Valeria, De Almeida, Beatriz Rocha, Simons, Simone Michaela, Mathias, Luis Antonio, Bassini-Silva, Ricardo, Machado, Rosangela Zacarias, André, Marcos Rogério, Barros-Battesti, Darci Moraes

“…is a Gram-negative, obligate intraerythrocytic bacterium that causes bovine anaplasmosis. While hard ticks of the genera and can be biological vectors,…”
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Gut transcriptome analysis on females of Ornithodoros mimon (Acari: Argasidae) and phylogenetic inference of ticks by Landulfo, Gabriel Alves, Patané, José Salvatore Leister, Silva, Dalton Giovanni Nogueira da, Junqueira-de-Azevedo, Inácio Loiola Meirelles, Mendonca, Ronaldo Zucatelli, Simons, Simone Michaela, Carvalho, Eneas de, Barros-Battesti, Darci Moraes

“…Ornithodoros mimon is an argasid tick that parasitizes bats, birds and opossums and is also harmful to humans. Knowledge of the transcripts present in the tick…”
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Antitumoral effects of Amblyomma sculptum Berlese saliva in neuroblastoma cell lines involve cytoskeletal deconstruction and cell cycle arrest by Nascimento, Thatyanne Gradowski do, Vieira, Priscilla Santos, Cogo, Sheron Campos, Dias-Netipanyj, Marcela Ferreira, França Junior, Nilton de, Câmara, Diana Aparecida Dias, Porcacchia, Allan Saj, Mendonça, Ronaldo Zucatelli, Moreno-Amaral, Andréa Novais, Sá Junior, Paulo Luiz de, Simons, Simone Michaela, Zischler, Luciana, Elifio-Esposito, Selene

“…The antitumor properties of ticks salivary gland extracts or recombinant proteins have been reported recently, but little is known about the antitumor…”
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Structural findings and molecular modeling approach of a TFPI-like inhibitor by Pasqualoto, Kerly Fernanda Mesquita, Balan, Andrea, Barreto, Sandra Alves, Simons, Simone Michaela, Chudzinski-Tavassi, Ana Marisa

“…Specific blood coagulation inhibitors from hematophagous organisms, with different structures and novel mechanism of action, have been described and they…”
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Artificial Feeding of IOrnithodoros fonsecai/I and IO. brasiliensis/I and Investigation of the Transstadial Perpetuation of IAnaplasma marginale/I by Castro-Santiago, Ana Carolina, Lima-Duarte, Leidiane, Camargo, Jaqueline Valeria, De Almeida, Beatriz Rocha, Simons, Simone Michaela, Mathias, Luis Antonio, Bassini-Silva, Ricardo, Machado, Rosangela Zacarias, André, Marcos Rogério, Barros-Battesti, Darci Moraes

“…Anaplasma marginale is a Gram-negative, obligate intraerythrocytic bacterium that causes bovine anaplasmosis. While hard ticks of the genera Dermacentor and…”
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Oviposition and eclosion periods of Ixodes didelphidis Fonseca and Aragão, 1951 (Acari: Ixodidae) under laboratory conditions by Barros-Battesti, D M, Onofrio, V C, Simons, S M, Bonoldi, V L, Yoshinari, N H

“…Oviposition and eclosion periods for Ixodes didelphidis were observed under two temperatures (25 degrees C and 27 degrees C) and 90-95% humidity. Although…”
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A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production by Maria, Durvanei Augusto, de Souza, Jean Gabriel, Morais, Katia L. P., Berra, Carolina Maria, Zampolli, Hamilton de Campos, Demasi, Marilene, Simons, Simone Michaela, de Freitas Saito, Renata, Chammas, Roger, Chudzinski-Tavassi, Ana Marisa

“…Summary In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2…”
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Pro-apoptotic effects of Amblyomin-X in murine renal cell carcinoma “in vitro” by Akagi, Erica Mie, Júnior, Paulo Luiz de Sá, Simons, Simone Michaela, Bellini, Maria Helena, Barreto, Sandra Alves, Chudzinski-Tavassi, Ana Marisa

“…Abstract Renal cell carcinoma (RCC) is one of the most lethal urologic cancers and is highly resistant to both radiotherapy and chemotherapy. The recombinant…”
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Apoptotic signaling of the Amblyomin‐X involves endoplasmic reticulum stress, cell cycle regulation and survival pathways by Chudzinski-Tavassi, Ana Marisa, Morais, Kátia Luciano Pereira, Souza, Jean Gabriel, Simons, Simone Michaela, Berra, Carolina Maria, Lameu, Claudiana

“…Abstract only…”
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Laboratory life cycle of Ornithodoros brasiliensis (Acari: Argasidae): An endemic tick from southern Brazil by Ramirez, Diego Garcia, Landulfo, Gabriel Alves, Onofrio, Valeria Castilho, Simons, Simone Michaela, Reck, José, Martins, João Ricardo, Labruna, Marcelo Bahia, Barros-Battesti, Darci Moraes

“…Aragão is an endemic tick restricted to the highlands of the state of Rio Grande do Sul, Brazil. This species is very aggressive toward humans, causing fever,…”
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A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis by Ventura, Janaína Souza, Faria, Fernanda, Batista, Isabel Fátima Correia, Simons, Simone Michaela, Oliveira, Daniella Gorete Lourenço, Morais, Katia L.P, Chudzinski-Tavassi, Ana Marisa

“…Abstract Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. In this study was demonstrated…”
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The action of Amblyomma cajennense tick saliva in compounds of the hemostatic system and cytotoxicity in tumor cell lines by Simons, Simone Michaela, Júnior, Paulo Luiz de Sá, Faria, Fernanda, Batista, Isabel de Fátima Correia, Barros-Battesti, Darci Moraes, Labruna, Marcelo Bahia, Chudzinski-Tavassi, Ana Marisa

“…Abstract Ticks are blood-feeding arthropods that secrete anticoagulant molecules to maintain the fluidity of the blood during its feeding. Tick saliva has many…”
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Immobilized kidney 28-kDa endostatin-related (KES28kDa) fragment promotes endothelial cell survival by Bellini, Maria Helena, Malpighi, Thiago França, Calvo, Fernanda Bernardes, Miranda, Adriana Regina, Spencer, Patrick Jack, Cichy, Milena Cristina, Simons, Simone Michaela, Chudzinski Tavassi, Ana Marisa, Fagundes dos Santos, Marinilce, Junqueira Rodrigues, Consuelo, Schor, Nestor

“…Renal ischemia-hypoxia is a leading cause of acute kidney injury (AKI). Ischemia causes extracellular matrix breakdown of the tubular basement membrane…”
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Oviposition and Eclosion Periods of Ixodes didelphidis Fonseca and Arago, 1951 (Acari: Ixodidae) under Laboratory Conditions by Darci Moraes Barros-Battesti, Valeria Castilho Onofrio, Simone Michaela Simons, Virginia Lucia Nazario Bonoldi, Natalino Hajime Yoshinari

“…Oviposition and eclosion periods for Ixodes didelphidis were observed under two temperatures (25C and 27C) and 90-95% humidity. Although there was a…”
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