Search Results - "Simon J. Gibbons"

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces by Wang, Fan, Knutson, Kaitlyn, Alcaino, Constanza, Linden, David R., Gibbons, Simon J., Kashyap, Purna, Grover, Madhusudan, Oeckler, Richard, Gottlieb, Philip A., Li, Hui Joyce, Leiter, Andrew B., Farrugia, Gianrico, Beyder, Arthur

“…Key points The gastrointestinal epithelial enterochromaffin (EC) cell synthesizes the vast majority of the body's serotonin. As a specialized mechanosensor,…”
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Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice by Cipriani, Gianluca, Gibbons, Simon J., Miller, Katie E., Yang, Daniel S., Terhaar, Matthew L., Eisenman, Seth T., Ördög, Tamas, Linden, David R., Gajdos, Gabriela B., Szurszewski, Joseph H., Farrugia, Gianrico

“…Muscularis propria macrophages lie close to cells that regulate gastrointestinal motor function, including interstitial cells of Cajal (ICC) and myenteric…”
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Heme Oxygenase-1 Protects Interstitial Cells of Cajal From Oxidative Stress and Reverses Diabetic Gastroparesis by Choi, Kyoung Moo, Gibbons, Simon J, Nguyen, Tien V, Stoltz, Gary J, Lurken, Matthew S, Ordog, Tamas, Szurszewski, Joseph H, Farrugia, Gianrico

“…Background & Aims Diabetic gastroparesis (delayed gastric emptying) is a well-recognized complication of diabetes that causes considerable morbidity and makes…”
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Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract by Gomez-Pinilla, Pedro J, Gibbons, Simon J, Bardsley, Michael R, Lorincz, Andrea, Pozo, Maria J, Pasricha, Pankaj J, Van de Rijn, Matt, West, Robert B, Sarr, Michael G, Kendrick, Michael L, Cima, Robert R, Dozois, Eric J, Larson, David W, Ordog, Tamas, Farrugia, Gianrico

“…Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by…”
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A simple automated approach to measure mouse whole gut transit by Kacmaz, Halil, Alto, Alecia, Knutson, Kaitlyn, Linden, David R., Gibbons, Simon J., Farrugia, Gianrico, Beyder, Arthur

“…Background Gastrointestinal (GI) motility is a complex physiological process that is critical for normal GI function. Disruption of GI motility frequently…”
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Ano1, a Ca2+‐activated Cl− channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal by Singh, Raman Deep, Gibbons, Simon J., Saravanaperumal, Siva Arumugam, Du, Peng, Hennig, Grant W., Eisenman, Seth T., Mazzone, Amelia, Hayashi, Yujiro, Cao, Chike, Stoltz, Gary J., Ordog, Tamas, Rock, Jason R., Harfe, Brian D., Szurszewski, Joseph H., Farrugia, Gianrico

“…Key points Ano1, a Ca2+‐activated Cl− channel, is expressed in interstitial cells of Cajal (ICC) throughout the gut. We report here that it is required to…”
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Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying by Hayashi, Yujiro, Toyomasu, Yoshitaka, Saravanaperumal, Siva Arumugam, Bardsley, Michael R, Smestad, John A, Lorincz, Andrea, Eisenman, Seth T, Cipriani, Gianluca, Nelson Holte, Molly H, Al Khazal, Fatimah J, Syed, Sabriya A, Gajdos, Gabriella B, Choi, Kyoung Moo, Stoltz, Gary J, Miller, Katie E, Kendrick, Michael L, Rubin, Brian P, Gibbons, Simon J, Bharucha, Adil E, Linden, David R, Maher, Louis James, Farrugia, Gianrico, Ordog, Tamas

“…Background & Aims Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes,…”
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Inhibition of cell proliferation by a selective inhibitor of the Ca2+-activated Cl− channel, Ano1 by Mazzone, Amelia, Eisenman, Seth T., Strege, Peter R., Yao, Zhen, Ordog, Tamas, Gibbons, Simon J., Farrugia, Gianrico

“…► T16Ainh-A01 blocked Ano1 currents in HEK cells expressing Ano1. ► T16Ainh-A01 reduced proliferation in ICC primary cultures and CFPAC-1 cell line. ►…”
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Ano1 as a regulator of proliferation by Stanich, Jennifer E, Gibbons, Simon J, Eisenman, Seth T, Bardsley, Michael R, Rock, Jason R, Harfe, Brian D, Ordog, Tamas, Farrugia, Gianrico

“…Ano1 is a recently discovered Ca(2+)-activated Cl(-) channel expressed on interstitial cells of Cajal (ICC) that has been implicated in slow-wave activity in…”
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Computational modeling of anoctamin 1 calcium-activated chloride channels as pacemaker channels in interstitial cells of Cajal by Lees-Green, Rachel, Gibbons, Simon J, Farrugia, Gianrico, Sneyd, James, Cheng, Leo K

“…Interstitial cells of Cajal (ICC) act as pacemaker cells in the gastrointestinal tract by generating electrical slow waves to regulate rhythmic smooth muscle…”
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Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins by Mazzone, Amelia, Gibbons, Simon J., Eisenman, Seth T., Strege, Peter R., Zheng, Tenghao, D'Amato, Mauro, Ordog, Tamas, Fernandez‐Zapico, Martin E., Farrugia, And Gianrico

“…ABSTRACTThe Ca2+‐activated Cl− channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion,…”
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Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis by Mazzone, Amelia, Bernard, Cheryl E., Strege, Peter R., Beyder, Arthur, Galietta, Luis J.V., Pasricha, Pankaj J., Rae, James L., Parkman, Henry P., Linden, David R., Szurszewski, Joseph H., Ördög, Tamas, Gibbons, Simon J., Farrugia, Gianrico

“…Diabetes affects many organs including the stomach. Altered number and function of interstitial cells of Cajal (ICC), the gastrointestinal pacemaker cells,…”
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Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis by Grover, Madhusudan, Gibbons, Simon J, Nair, Asha A, Bernard, Cheryl E, Zubair, Adeel S, Eisenman, Seth T, Wilson, Laura A, Miriel, Laura, Pasricha, Pankaj J, Parkman, Henry P, Sarosiek, Irene, McCallum, Richard W, Koch, Kenneth L, Abell, Thomas L, Snape, William J, Kuo, Braden, Shulman, Robert J, McKenzie, Travis J, Kellogg, Todd A, Kendrick, Michael L, Tonascia, James, Hamilton, Frank A, Farrugia, Gianrico

“…Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis…”
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Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis by Gibbons, Simon J, Grover, Madhusudan, Choi, Kyoung Moo, Wadhwa, Akhilesh, Zubair, Adeel, Wilson, Laura A, Wu, Yanhong, Abell, Thomas L, Hasler, William L, Koch, Kenneth L, McCallum, Richard W, Nguyen, Linda A B, Parkman, Henry P, Sarosiek, Irene, Snape, William J, Tonascia, James, Hamilton, Frank A, Pasricha, Pankaj J, Farrugia, Gianrico

“…Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to…”
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The role of carbon monoxide in the gastrointestinal tract by Gibbons, Simon J., Farrugia, Gianrico

“…Carbon monoxide (CO) is a biologically active product of haem metabolism that contributes to the normal physiology of the gastrointestinal tract. In this…”
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A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2 by Strege, Peter R, Bernard, Cheryl E, Mazzone, Amelia, Linden, David R, Beyder, Arthur, Gibbons, Simon J, Farrugia, Gianrico

“…Anoctamin 1 (Ano1; TMEM16A) is a Ca(2+)-activated Cl(-) channel (CACC) expressed in interstitial cells of Cajal. The mechanisms by which Ca(2+) regulates Ano1…”
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Carbon monoxide reverses diabetic gastroparesis in NOD mice by Kashyap, Purna C, Choi, Kyoung Moo, Dutta, Nirjhar, Linden, David R, Szurszewski, Joseph H, Gibbons, Simon J, Farrugia, Gianrico

“…Diabetic gastroparesis is associated with increased oxidative stress attributable to loss of upregulation of heme oxygenase-1 (HO1), with resultant damage to…”
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Numerical metrics for automated quantification of interstitial cell of Cajal network structural properties by Gao, Jerry, Du, Peng, O'Grady, Greg, Archer, Rosalind, Farrugia, Gianrico, Gibbons, Simon J., Cheng, Leo K.

“…Depletion of interstitial cells of Cajal (ICC) networks is known to occur in several gastrointestinal motility disorders. Although confocal microscopy can…”
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Exogenous Serotonin Regulates Proliferation of Interstitial Cells of Cajal in Mouse Jejunum Through 5-HT2B Receptors by Wouters, Mira M, Gibbons, Simon J, Roeder, Jaime L, Distad, Marne, Ou, Yijun, Strege, Peter R, Szurszewski, Joseph H, Farrugia, Gianrico

“…Background & Aims: Interstitial cells of Cajal (ICC) are required for normal gastrointestinal motility. Loss of ICC is associated with several motility…”
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A Mutation in Telethonin Alters Nav1.5 Function by Mazzone, Amelia, Strege, Peter R., Tester, David J., Bernard, Cheryl E., Faulkner, Georgine, De Giorgio, Roberto, Makielski, Jonathan C., Stanghellini, Vincenzo, Gibbons, Simon J., Ackerman, Michael J., Farrugia, Gianrico

“…Excitable cells express a variety of ion channels that allow rapid exchange of ions with the extracellular space. Opening of Na+ channels in excitable cells…”
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