Search Results - "Simon, Ted W."

In vitro to in vivo extrapolation for high throughput prioritization and decision making by Bell, Shannon M., Chang, Xiaoqing, Wambaugh, John F., Allen, David G., Bartels, Mike, Brouwer, Kim L.R., Casey, Warren M., Choksi, Neepa, Ferguson, Stephen S., Fraczkiewicz, Grazyna, Jarabek, Annie M., Ke, Alice, Lumen, Annie, Lynn, Scott G., Paini, Alicia, Price, Paul S., Ring, Caroline, Simon, Ted W., Sipes, Nisha S., Sprankle, Catherine S., Strickland, Judy, Troutman, John, Wetmore, Barbara A., Kleinstreuer, Nicole C.

“…In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To…”
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Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes by Patlewicz, Grace, Simon, Ted W., Rowlands, J. Craig, Budinsky, Robert A., Becker, Richard A.

“…•Application of AOPs is context dependent.•Regulatory context will drive the scientific confidence needed.•A scientific confidence framework is proposed.•Case…”
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An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept by Becker, Richard A., Friedman, Katie Paul, Simon, Ted W., Marty, M. Sue, Patlewicz, Grace, Rowlands, J. Craig

“…•A method for providing context for HTS endocrine assays is presented.•The exposure:activity ratio (EAR) can place HTS activity in the context of human…”
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The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events by Simon, Ted W., Simons, S. Stoney, Preston, R. Julian, Boobis, Alan R., Cohen, Samuel M., Doerrer, Nancy G., Fenner-Crisp, Penelope A., McMullin, Tami S., McQueen, Charlene A., Rowlands, J. Craig

“…Abstract The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop strategies for using all available data (in vitro, in vivo, and in…”
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A model for aryl hydrocarbon receptor-activated gene expression shows potency and efficacy changes and predicts squelching due to competition for transcription co-activators by Simon, Ted W, Budinsky, Robert A, Rowlands, J Craig

“…A stochastic model of nuclear receptor-mediated transcription was developed based on activation of the aryl hydrocarbon receptor (AHR) by…”
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Providing context for phosphatidylethanol as a biomarker of alcohol consumption with a pharmacokinetic model by Simon, Ted W.

“…Phosphatidylethanol (PEth) is increasingly used as a biomarker of heavy drinking. Many different forms of PEth can form in red blood cell membranes from the…”
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Letter to the Editor: Modeling the changing face of Phosphatidylethanol's window of detection by Nguyen, Van Long, Simon, Ted W.

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Commentary: Value of information case study strongly supports use of the Threshold of Toxicological Concern (TTC) by Simon, Ted W., Ryman, Jessica, Becker, Richard A.

“…A Value of Information (VOI) analysis can play a key role in decision-making for adopting new approach methodologies (NAMs). We applied EPA's recently…”
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Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors by Eaton, David L., Simon, Ted W., Kaminski, Norbert E., Perdew, Gary H., Nebert, Daniel W.

“…In 2022 the World Health Organization (WHO) published updated ‘Toxic Equivalence Factors’ (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and…”
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The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment by Eaton, David L., Simon, Ted W., Kaminski, Norbert E., Perdew, Gary H., Nebert, Daniel W.

“…•The WHO Committee relied largely on data from laboratory studies on rodents to determine Toxic Equivalence Factors (TEFs).•Extensive literature with human…”
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The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor by Becker, Richard A., Patlewicz, Grace, Simon, Ted W., Rowlands, J. Craig, Budinsky, Robert A.

“…An Adverse Outcome Pathway (AOP) represents the existing knowledge of a biological pathway leading from initial molecular interactions of a toxicant and…”
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Bayesian methods for uncertainty factor application for derivation of reference values by Simon, Ted W., Zhu, Yiliang, Dourson, Michael L., Beck, Nancy B.

“…In 2014, the National Research Council (NRC) published Review of EPA’s Integrated Risk Information System (IRIS) Process that considers methods EPA uses for…”
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How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data? by Becker, Richard A., Dreier, David A., Manibusan, Mary K., Cox, Louis A. (Tony), Simon, Ted W., Bus, James S.

“…IARC has begun using ToxCast/Tox21 data in efforts to represent key characteristics of carcinogens to organize and weigh mechanistic evidence in cancer hazard…”
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Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals by Patlewicz, Grace, Wambaugh, John F., Felter, Susan P., Simon, Ted W., Becker, Richard A.

“…•An approach of using TTC and HTE to facilitate risk-based prioritization is presented.•Used the Kroes et al. (2004) workflow to identify the number of…”
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Two-Dimensional Monte Carlo Simulation and Beyond: A Comparison of Several Probabilistic Risk Assessment Methods Applied to a Superfund Site by Simon, Ted W.

“…Four different probabilistic risk assessment methods were compared using the data from the Sangamo Weston/Lake Hartwell Superfund site. These were…”
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Modeling a Neural Oscillator That Paces Heartbeat in the Medicinal Leech by De Schutter, Erik, Ted W. Simon, Angstadt, James D., Calabrese, Ronald L.

“…Heartbeat in the medicinal leech is paced by a neural oscillator comprising two elemental oscillators whose activity is coordinated by intersegmental…”
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Olfaction and prey search in the carnivorous leech Haemopis marmorata by Simon, T, Barnes, K

“…Haemopis marmorata, the green horse leech, is carnivorous and readily eats earthworms. Using a Y-maze with flowing water, we show that specimens of H…”
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Can the Predictive Analytics Toolkit (PAT) handle a genomic data set? by Simon, Ted W., (Tony) Cox, Louis A., Becker, Richard A.

“…•The Predictive Analytics Toolkit (PAT) is a user-friendly web application.•PAT correctly predicted in vivo transcriptomic responses from Tox21 AC50…”
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The Predictive Analytics Toolkit (PAT): User-friendly predictive analytics for advancing new approach methodologies (NAMs) by Cox, Louis A. (Tony), Simon, Ted W., Becker, Richard A.

“…Advanced test systems and knowledge of biology, how chemical exposures occur, and the mechanisms, pathways and dose-dependent changes that can lead to toxicity…”
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Bayesian Statistics in Environmental Engineering Planning by Englehardt, James D, Simon, Ted W

“…Bayesian inference can provide a rigorous assessment of risk based on the information available. Today's environmental engineer faces many uncertainties in…”
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