Search Results - "Simon, Silke"

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies by Lucas, Xavier, Simon, Silke, Schubert, Rolf, Günther, Stefan

“…P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and…”
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Dose Escalation of HLA-A2-WT1 CD3 T-Cell Bispecific Antibody in a Phase I Study in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) by Hutchings, Martin, Montesinos, Pau, Santoro, Armando, Hou, Hsin-An, Martinez-Sanchez, Maria Pilar, Vives, Susana, Galimberti, Sara, Chen, Tsai-Yun, Frigeni, Marco, Garciaz, Sylvain, Salamero, Olga, Yeh, Su-Peng, Yee, Karen, Schnetzler, Gabriel, Barata, Teresa, Simon, Silke, Hinton, Heather, Korfi, Koorosh, Richard, Muriel, Keshelava, Nino, Subklewe, Marion

“…Background: RO7283420 (RG6007) is a 2+1 TCR-like (TCR-L) T-cell bispecific (TCB) antibody targeting CD3 and the RMFPNAPYL peptide of Wilms Tumor 1 (WT1)…”
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Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study by Yee, Karen, Papayannidis, Cristina, Vey, Norbert, Dickinson, Michael J., Kelly, Kevin R., Assouline, Sarit, Kasner, Margaret, Seiter, Karen, Drummond, Mark W., Yoon, Sung-Soo, Lee, Je-Hwan, Blotner, Steven, Jukofsky, Lori, Pierceall, William E., Zhi, Jianguo, Simon, Silke, Higgins, Brian, Nichols, Gwen, Monnet, Annabelle, Muehlbauer, Susanne, Ott, Marion, Chen, Lin-Chi, Martinelli, Giovanni

“…•Idasanutlin (RG7388) is a novel and potent oral MDM2 antagonist.•Idasanutlin alone or with cytarabine was assessed in acute myeloid leukemia.•Idasanutlin…”
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Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1 by Sánchez, Javier, Nicolini, Valeria, Fahrni, Linda, Waldhauer, Inja, Walz, Antje-Christine, Jamois, Candice, Fowler, Stephen, Simon, Silke, Klein, Christian, Umaña, Pablo, Friberg, Lena E., Frances, Nicolas

“…TYRP1-TCB is a CD3 T-cell bispecific (CD3-TCB) antibody for the treatment of advanced melanoma. A tumor growth inhibition (TGI) model was developed using mouse…”
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Correction: Preclinical In Vivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T‑Cell Bispecific in Combination with Anti‑PD‑L1 by Sánchez, Javier, Nicolini, Valeria, Fahrni, Linda, Waldhauer, Inja, Walz, Antje‑Christine, Jamois, Candice, Fowler, Stephen, Simon, Silke, Klein, Christian, Umaña, Pablo, Friberg, Lena E., Frances, Nicolas

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Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms by Jaramillo, Claudia A Castro, Belli, Sara, Cascais, Anne-Christine, Dudal, Sherri, Edelmann, Martin R, Haak, Markus, Brun, Marie-Elise, Otteneder, Michael B, Ullah, Mohammed, Funk, Christoph, Schuler, Franz, Simon, Silke

“…Monoclonal antibodies (mAbs) are a rapidly growing drug class for which great efforts have been made to optimize certain molecular features to achieve the…”
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Discovery of the Inhibitory Effect of a Phosphatidylinositol Derivative on P-Glycoprotein by Virtual Screening Followed by In Vitro Cellular Studies. e60679 by Lucas, Xavier, Simon, Silke, Schubert, Rolf, Guenther, Stefan

“…P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and…”
Get full text

Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms by Jaramillo, Claudia A. Castro, Belli, Sara, Cascais, Anne-Christine, Dudal, Sherri, Edelmann, Martin R., Haak, Markus, Brun, Marie-Elise, Otteneder, Michael B., Ullah, Mohammed, Funk, Christoph, Schuler, Franz, Simon, Silke

“…Monoclonal antibodies (mAbs) are a rapidly growing drug class for which great efforts have been made to optimize certain molecular features to achieve the…”
Get full text