Search Results - "Simon, P L"

Mucosal healing in inflammatory bowel diseases: a systematic review by Neurath, Markus F, Travis, Simon P L

“…Recent studies have identified mucosal healing on endoscopy as a key prognostic parameter in the management of inflammatory bowel diseases (IBD), thus…”
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Current best practice for disease activity assessment in IBD by Walsh, Alissa J., Bryant, Robert V., Travis, Simon P. L.

“…Key Points Objective assessment of disease activity in IBD is important for guiding subsequent therapy as part of a 'treat to target' strategy Multiple domains…”
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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial by Hueber, Wolfgang, Sands, Bruce E, Lewitzky, Steve, Vandemeulebroecke, Marc, Reinisch, Walter, Higgins, Peter D R, Wehkamp, Jan, Feagan, Brian G, Yao, Michael D, Karczewski, Marek, Karczewski, Jacek, Pezous, Nicole, Bek, Stephan, Bruin, Gerard, Mellgard, Bjoern, Berger, Claudia, Londei, Marco, Bertolino, Arthur P, Tougas, Gervais, Travis, Simon P L

“…The authors tested whether the anti-interleukin (IL)-17A monoclonal antibody secukinumab was safe and effective for the treatment of active Crohn's disease. In…”
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Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit by Hearnshaw, Sarah A, Logan, Richard F A, Lowe, Derek, Travis, Simon P L, Murphy, Mike F, Palmer, Kelvin R

“…To describe the patient characteristics, diagnoses and clinical outcomes of patients presenting with acute upper gastrointestinal bleeding (AUGIB) in the 2007…”
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Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) by Travis, Simon P L, Schnell, Dan, Krzeski, Piotr, Abreu, Maria T, Altman, Douglas G, Colombel, Jean-Frédéric, Feagan, Brian G, Hanauer, Stephen B, Lémann, Marc, Lichtenstein, Gary R, Marteau, Phillippe R, Reinisch, Walter, Sands, Bruce E, Yacyshyn, Bruce R, Bernhardt, Christian A, Mary, Jean-Yves, Sandborn, William J

“…Variability in endoscopic assessment necessitates rigorous investigation of descriptors for scoring severity of ulcerative colitis (UC). To evaluate variation…”
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Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation by Ryzhakov, Grigory, Almuttaqi, Hannah, Corbin, Alastair L., Berthold, Dorothée L., Khoyratty, Tariq, Eames, Hayley L., Bullers, Samuel, Pearson, Claire, Ai, Zhichao, Zec, Kristina, Bonham, Sarah, Fischer, Roman, Jostins-Dean, Luke, Travis, Simon P. L., Kessler, Benedikt M., Udalova, Irina A.

“…Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5…”
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The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organisation: Pregnancy and Pediatrics by MAHADEVAN, Uma, CUCCHIARA, Salvatore, HYAMS, Jeffrey S, STEINWURZ, Flavio, NUTI, F, TRAVIS, Simon P. L, SANDBORN, William J, COLOMBEL, Jean-Frederio

“…Women with inflammatory bowel disease (IBD) have similar rates of fertility to the general population, but have an increased rate of adverse pregnancy outcomes…”
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IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease by Geremia, Alessandra, Arancibia-Cárcamo, Carolina V, Fleming, Myles P P, Rust, Nigel, Singh, Baljit, Mortensen, Neil J, Travis, Simon P L, Powrie, Fiona

“…Results of experimental and genetic studies have highlighted the role of the IL-23/IL-17 axis in the pathogenesis of inflammatory bowel disease (IBD)…”
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Consensus for Managing Acute Severe Ulcerative Colitis in Children: A Systematic Review and Joint Statement From ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN by Turner, Dan, Travis, Simon P L, Griffiths, Anne M, Ruemmele, Frank M, Levine, Arie, Benchimol, Eric I, Dubinsky, Marla, Alex, George, Baldassano, Robert N, Langer, Jacob C, Shamberger, Robert, Hyams, Jeffrey S, Cucchiara, Salvatore, Bousvaros, Athos, Escher, Johanna C, Markowitz, James, Wilson, David C, van Assche, Gert, Russell, Richard K

“…Acute severe ulcerative colitis (ASC) is a potentially life-threatening disease. We aimed to formulate guidelines for managing ASC in children based on…”
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Limited uptake of ulcerative colitis “treat‐to‐target” recommendations in real‐world practice by Bryant, Robert V, Costello, Samuel P, Schoeman, Scott, Sathananthan, Dharshan, Knight, Emma, Lau, Su‐Yin, Schoeman, Mark N, Mountifield, Reme, Tee, Derrick, Travis, Simon P L, Andrews, Jane M

“…Background and Aims A “treat‐to‐target” approach has been proposed for ulcerative colitis (UC), with a target of combined clinical and endoscopic remission…”
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Use of endoscopy for management of acute upper gastrointestinal bleeding in the UK: results of a nationwide audit by Hearnshaw, Sarah A, Logan, Richard F A, Lowe, Derek, Travis, Simon P L, Murphy, Mike F, Palmer, Kelvin R

“…To examine the use of endoscopy in the UK for acute upper gastrointestinal bleeding (AUGIB) and compare with published standards. To assess the organisation of…”
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Autologous Haematopoietic Stem Cell Transplantation for Crohn's Disease: A Retrospective Survey of Long-term Outcomes From the European Society for Blood and Marrow Transplantation by Brierley, Charlotte K, Castilla-Llorente, Cristina, Labopin, Myriam, Badoglio, Manuela, Rovira, Montserrat, Ricart, Elena, Dierickx, Daan, Vermeire, Severine, Hasselblatt, Peter, Finke, Juergen, Onida, Francesco, Cassinotti, Andrea, Satsangi, Jack, Kazmi, Majid, López-Sanromán, Antonio, Schmidt, Carsten, Farge, Dominique, Travis, Simon P L, Hawkey, Chris J, Snowden, John A

“…Autologous haematopoietic stem cell transplantation [AHSCT] is a therapeutic option for patients with severe, treatment-refractory Crohn's disease [CD]. The…”
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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts by Leedham, Simon J, Rodenas-Cuadrado, Pedro, Howarth, Kimberley, Lewis, Annabelle, Mallappa, Sreelakshmi, Segditsas, Stefania, Davis, Hayley, Jeffery, Rosemary, Rodriguez-Justo, Manuel, Keshav, Satish, Travis, Simon P L, Graham, Trevor A, East, James, Clark, Susan, Tomlinson, Ian P M

“…Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an…”
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Efficacy of oral prolonged‐release mesalazine in moderately active ulcerative colitis by Paridaens, Kristine, Fullarton, John R, Travis, Simon P L

“…New meta‐analyses are presented that provide further evidence supporting the effectiveness of oral prolonged‐release mesalazine compared to other oral…”
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Machine learning in the assessment and management of acute gastrointestinal bleeding by Nigam, Gaurav Bhaskar, Murphy, Michael F, Travis, Simon P L, Stanley, Adrian J

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Correlation Between Endoscopic and Histological Activity in Ulcerative Colitis Using Validated Indices by Irani, Nazneen R, Wang, Lai Mun, Collins, Gary S, Keshav, Satish, Travis, Simon P L

“…Endoscopy and histopathology are pivotal for evaluating disease activity in ulcerative colitis [UC]; correlation between validated endoscopic and histological…”
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Prevalence, management, and outcomes of patients with coagulopathy after acute nonvariceal upper gastrointestinal bleeding in the United Kingdom by Jairath, Vipul, Kahan, Brennan C., Stanworth, Simon J., Logan, Richard F.A., Hearnshaw, Sarah A., Travis, Simon P.L., Palmer, Kelvin R., Murphy, Michael F.

“…BACKGROUND: Coagulopathy after major hemorrhage has been found to be an independent risk factor for mortality after traumatic bleeding. It is unclear whether…”
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The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organisation: Safety by VAN ASSCHE, Gert, LEWIS, James D, LICHTENSTEIN, Gary R, LOFTUS, Edward V, QIN OUYANG, PANES, Julian, SIEGEL, Corey A, SANDBORN, William J, TRAVIS, Simon P. L, COLOMBEL, Jean-Frederic

“…This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in…”
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Fistulating Anal Crohnʼs Disease: Results of Combined Surgical and Infliximab Treatment by Hyder, Syed A, Travis, Simon P. L, Jewell, Derek P, McC. Mortensen, Neil J, George, Bruce D

“…INTRODUCTION: METHODS: RESULTS:Twenty-two patients underwent infliximab treatment (6 males; median age, 35 (range, 16-60) years). Twenty-one patients had…”
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Use of the Obesity Surgery Mortality Risk Score to Predict Complications of Laparoscopic Bariatric Surgery by Sarela, Abeezar I., Dexter, Simon P. L., McMahon, Michael J.

“…Background This study aimed to evaluate the role of the Obesity Surgery Mortality Risk Score (OS-MRS) to predict the risk of post-operative adverse events, in…”
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