Search Results - "Simon, Julian"

The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis by Lucas, Jared M, Heinlein, Cynthia, Kim, Tom, Hernandez, Susana A, Malik, Muzdah S, True, Lawrence D, Morrissey, Colm, Corey, Eva, Montgomery, Bruce, Mostaghel, Elahe, Clegg, Nigel, Coleman, Ilsa, Brown, Christopher M, Schneider, Eric L, Craik, Charles, Simon, Julian A, Bedalov, Antonio, Nelson, Peter S

“…TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized…”
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The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion by Dembitz, Vilma, Tomic, Barbara, Kodvanj, Ivan, Simon, Julian A., Bedalov, Antonio, Visnjic, Dora

“…Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a…”
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Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors by Mahajan, Sumit S, Scian, Michele, Sripathy, Smitha, Posakony, Jeff, Lao, Uyen, Loe, Taylor K, Leko, Vid, Thalhofer, Angel, Schuler, Aaron D, Bedalov, Antonio, Simon, Julian A

“…Sirtuins are a family of NAD+-dependent protein deacetylases that play critical roles in epigenetic regulation, stress responses, and cellular aging in…”
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Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death by Owens, Kelly N, Santos, Felipe, Roberts, Brock, Linbo, Tor, Coffin, Allison B, Knisely, Anna J, Simon, Julian A, Rubel, Edwin W, Raible, David W

“…Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide…”
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Long-term tracking demonstrates effectiveness of a partnership-led training program to advance the careers of biomedical researchers from underrepresented groups by Thompson, Beti, O'Connell, Mary A, Peterson, Karen, Shuster, Michele, Drennan, Marilyn, Loest, Helena, Holte, Sarah, Simon, Julian A, Unguez, Graciela A

“…The demographic profile of the biomedical workforce in the U.S. does not reflect the population at large, raising concerns that there will be insufficient…”
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Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss by Chowdhury, Sarwat, Owens, Kelly N, Herr, R. Jason, Jiang, Qin, Chen, Xinchao, Johnson, Graham, Groppi, Vincent E, Raible, David W, Rubel, Edwin W, Simon, Julian A

“…Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells,…”
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Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin by Jacquemont, Céline, Simon, Julian A, D'Andrea, Alan D, Taniguchi, Toshiyasu

“…Platinum compounds such as cisplatin and carboplatin are DNA crosslinking agents widely used for cancer chemotherapy. However, the effectiveness of platinum…”
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Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity by Davis, Samantha N., Wu, Patricia, Camci, Esra D., Simon, Julian A., Rubel, Edwin W., Raible, David W.

“…Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the…”
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Tailored magnetic nanoparticles for optimizing magnetic fluid hyperthermia by Khandhar, Amit P., Ferguson, R. Matthew, Simon, Julian A., Krishnan, Kannan M.

“…Magnetic Fluid Hyperthermia (MFH) is a promising approach towards adjuvant cancer therapy that is based on the localized heating of tumors using the relaxation…”
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Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies by Chowdhury, Sarwat, Sripathy, Smitha, Webster, Alyssa, Park, Angela, Lao, Uyen, Hsu, Joanne H, Loe, Taylor, Bedalov, Antonio, Simon, Julian A

“…Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD -dependent protein deacylase, have therapeutic effects in various cancers…”
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Inhibition of vaccinia virus replication by nitazoxanide by Hickson, Sarah E., Margineantu, Daciana, Hockenbery, David M., Simon, Julian A., Geballe, Adam P.

“…Nitazoxanide (NTZ) is an FDA-approved anti-protozoal drug that inhibits several bacteria and viruses as well. However, its effect on poxviruses is unknown…”
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A Proteomic Investigation of Ligand-dependent HSP90 Complexes Reveals CHORDC1 as a Novel ADP-dependent HSP90-interacting Protein by Gano, Jacob J., Simon, Julian A.

“…Structural studies of the chaperone HSP90 have revealed that nucleotide and drug ligands induce several distinct conformational states; however, little is…”
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PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation by Jehn, Julia, Gebert, Daniel, Pipilescu, Frank, Stern, Sarah, Kiefer, Julian Simon Thilo, Hewel, Charlotte, Rosenkranz, David

“…PIWI proteins and PIWI-interacting RNAs (piRNAs) suppress transposon activity in animals, thus protecting their genomes from detrimental insertion mutagenesis…”
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Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores by Lewis, Victor M., Saunders, Lauren M., Larson, Tracy A., Bain, Emily J., Sturiale, Samantha L., Gur, Dvir, Chowdhury, Sarwat, Flynn, Jessica D., Allen, Michael C., Deheyn, Dimitri D., Lee, Jennifer C., Simon, Julian A., Lippincott-Schwartz, Jennifer, Raible, David W., Parichy, David M.

“…Understanding genetic and cellular bases of adult form remains a fundamental goal at the intersection of developmental and evolutionary biology. The skin…”
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CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy by Battis, Kristina, Florio, Jazmin B, Mante, Michael, Lana, Addison, Naumann, Isabel, Gauer, Carina, Lambrecht, Vera, Müller, Simon Julian, Cobo, Isidoro, Fixsen, Bethany, Kim, Ha Yeon, Masliah, Eliezer, Glass, Christopher K, Schlachetzki, Johannes C M, Rissman, Robert A, Winkler, Jürgen, Hoffmann, Alana

“…As the CNS-resident macrophages and member of the myeloid lineage, microglia fulfill manifold functions important for brain development and homeostasis. In the…”
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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes by HELTWEG, Birgit, GATBONTON, Tonibelle, BEDALOV, Antonio, SCHULER, Aaron D, POSAKONY, Jeff, HONGZHE LI, GOEHLE, Sondra, KOLLIPARA, Ramya, DEPINHO, Ronald A, YANSONG GU, SIMON, Julian A

“…SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of…”
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Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast by Gatbonton, Tonibelle, Imbesi, Maria, Nelson, Melisa, Akey, Joshua M, Ruderfer, Douglas M, Kruglyak, Leonid, Simon, Julian A, Bedalov, Antonio

“…Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes and pathways that regulate telomere length. We found 72…”
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Inhibition of a nutritional endosymbiont by glyphosate abolishes mutualistic benefit on cuticle synthesis in Oryzaephilus surinamensis by Kiefer, Julian Simon Thilo, Batsukh, Suvdanselengee, Bauer, Eugen, Hirota, Bin, Weiss, Benjamin, Wierz, Jürgen C., Fukatsu, Takema, Kaltenpoth, Martin, Engl, Tobias

“…Glyphosate is widely used as a herbicide, but recent studies begin to reveal its detrimental side effects on animals by targeting the shikimate pathway of…”
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Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line by Thomas, Andrew J, Hailey, Dale W, Stawicki, Tamara M, Wu, Patricia, Coffin, Allison B, Rubel, Edwin W, Raible, David W, Simon, Julian A, Ou, Henry C

“…Cisplatin, one of the most commonly used anticancer drugs, is known to cause inner ear hair cell damage and hearing loss. Despite much investigation into…”
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Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line by Ou, Henry, Simon, Julian A., Rubel, Edwin W., Raible, David W.

“…The zebrafish lateral line is an efficient model system for the evaluation of chemicals that protect and damage hair cells. Located on the surface of the body,…”
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