Search Results - "Simon, J.S."
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The metabolomic detection of lung cancer biomarkers in sputum
Published in Lung cancer (Amsterdam, Netherlands) (01-04-2016)“…Highlights • We examine sputum for non-invasive metabolomic biomarkers for lung cancer. • Metabolome profiles of sputum constructed using two mass spectrometry…”
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Photocatalytic Oxidative Iodination of Electron‐Rich Arenes
Published in Advanced synthesis & catalysis (03-09-2019)“…A visible‐light‐mediated oxidative iodination of electron‐rich arenes has been developed. 2.5 mol% of unsubstituted anthraquinone as photocatalyst were used in…”
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Rapid ex vivo molecular fingerprinting of biofluids using laser-assisted rapid evaporative ionization mass spectrometry
Published in Nature protocols (01-09-2021)“…Of the many metabolites involved in any clinical condition, only a narrow range of biomarkers is currently being used in the clinical setting. A key to…”
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The human salivary microbiome exhibits temporal stability in bacterial diversity
Published in FEMS microbiology ecology (01-09-2015)“…The temporal variability of the human microbiome may be an important factor in determining its relationship with health and disease. In this study, the saliva…”
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Utilisation of Ambient Laser Desorption Ionisation Mass Spectrometry (ALDI-MS) Improves Lipid-Based Microbial Species Level Identification
Published in Scientific reports (28-02-2019)“…The accurate and timely identification of the causative organism of infection is important in ensuring the optimum treatment regimen is prescribed for a…”
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Metabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry
Published in Scientific reports (19-07-2018)“…Rapid evaporative ionisation mass spectrometry (REIMS) is a novel technique for the real-time analysis of biological material. It works by conducting an…”
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Coupled cryoconite ecosystem structure–function relationships are revealed by comparing bacterial communities in alpine and Arctic glaciers
Published in FEMS microbiology ecology (01-08-2014)“…Abstract Cryoconite holes are known as foci of microbial diversity and activity on polar glacier surfaces, but are virtually unexplored microbial habitats in…”
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Laser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening
Published in EBioMedicine (01-10-2020)“…The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the…”
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Characterization of the rumen lipidome and microbiome of steers fed a diet supplemented with flax and echium oil
Published in Microbial biotechnology (01-03-2015)“…Summary Developing novel strategies for improving the fatty acid composition of ruminant products relies upon increasing our understanding of rumen bacterial…”
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Effects of bovine colostrum supplementation on upper respiratory illness in active males
Published in Brain, behavior, and immunity (01-07-2014)“…Highlight • This is the first study on salivary microbiome in athletes, showing increased bacterial load during winter months which is limited with bovine…”
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Metabolomic and Metataxonomic Fingerprinting of Human Milk Suggests Compositional Stability over a Natural Term of Breastfeeding to 24 Months
Published in Nutrients (11-11-2020)“…Sparse data exist regarding the normal range of composition of maternal milk beyond the first postnatal weeks. This single timepoint, observational study in…”
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Visible-Light Photo-Arbuzov Reaction of Aryl Bromides and Trialkyl Phosphites Yielding Aryl Phosphonates
Published in ACS catalysis (02-12-2016)“…Aryl phosphonates are functional groups frequently found in pharmaceutical and crop protection agents. For their synthesis via C–P bond formation typically…”
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Mass spectrometry approaches to metabolic profiling of microbial communities within the human gastrointestinal tract
Published in Methods (San Diego, Calif.) (01-10-2018)“…•Mass spectrometry provides an ideal tool for metabolic profiling of microbial communities.•Wide range of approaches suited for different metabolites of…”
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Visible-Light-Mediated Nitration of Protected Anilines
Published in Journal of organic chemistry (02-03-2018)“…The photocatalytic nitration of protected anilines proceeds with riboflavin tetraacetate as an organic photoredox catalyst. Sodium nitrite serves as the NO2…”
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A Kinetic Partitioning Model of Selective Binding of Nonnative Proteins by the Bacterial Chaperone SecB
Published in Science (American Association for the Advancement of Science) (25-01-1991)“…An in vitro assay for the interaction of SecB, a molecular chaperone from Escherichia coli, with polypeptide ligands was established based on the ability of…”
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A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer
Published in PloS one (25-05-2017)“…Lung cancer (LC) is the most prevalent cancer worldwide, and responsible for over 1.3 million deaths each year. Currently, LC has a low five year survival…”
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Automated High-Throughput Identification and Characterization of Clinically Important Bacteria and Fungi using Rapid Evaporative Ionization Mass Spectrometry
Published in Analytical chemistry (Washington) (04-10-2016)“…Rapid evaporative ionization mass spectrometry (REIMS) has been shown to quickly and accurately speciate microorganisms based upon their species-specific lipid…”
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Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Provides Accurate Direct from Culture Species Identification within the Genus Candida
Published in Scientific reports (14-11-2016)“…Members of the genus Candida , such as C. albicans and C. parapsilosis , are important human pathogens. Other members of this genus, previously believed to…”
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Sample Preparation Free Mass Spectrometry Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry: Applications to Microbiology, Metabolic Biofluid Phenotyping, and Food Authenticity
Published in Journal of the American Society for Mass Spectrometry (02-06-2021)“…Mass spectrometry has established itself as a powerful tool in the chemical, biological, medical, environmental, and agricultural fields. However, experimental…”
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Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study
Published in Biochimica et biophysica acta (01-11-2016)“…Lung cancer (LC) is one of the leading lethal cancers worldwide, with an estimated 18.4% of all cancer deaths being attributed to the disease. Despite…”
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