Search Results - "Simon, Geisler"

The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota by Leblhuber, Friedrich, Ehrlich, Daniela, Steiner, Kostja, Geisler, Simon, Fuchs, Dietmar, Lanser, Lukas, Kurz, Katharina

“…The microbiota-gut-brain axis plays an important role in the development of neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence…”
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On the Possible Relevance of Bottom-up Pathways in the Pathogenesis of Alzheimer's Disease by Leblhuber, Friedrich, Steiner, Kostja, Geisler, Simon, Fuchs, Dietmar, Gostner, Johanna M

“…Dementia is an increasing health problem in older aged populations worldwide. Age-related changes in the brain can be observed decades before the first…”
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Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism by Capuron, Lucile, Geisler, Simon, Kurz, Katharina, Leblhuber, Friedrich, Sperner-Unterweger, Barbara, Fuchs, Dietmar

“…Immune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a…”
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Immunometabolism in the Pathogenesis of Depressive Disorders - Therapeutic Considerations by Geisler, Simon, Sperner-Unterweger, Barbara, Fuchs, Dietmar, Gostner, Johanna M

“…There exists a critical link between immunological processes and metabolic changes. Furthermore, it becomes more and more evident that changes in…”
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Serum tryptophan, kynurenine, phenylalanine, tyrosine and neopterin concentrations in 100 healthy blood donors by Geisler Simon, Mayersbach Peter, Becker Kathrin, Schennach Harald, Fuchs Dietmar, Gostner Johanna M.

“…Formation of neopterin, a biomarker of the activated human immune system, is linked with tryptophan (TRP) and phenylalanine (PHE) metabolism. To obtain normal…”
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Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery by Geisler, Simon, Lytton, Simon D., Toan, Nguyen Linh, Nghia, Trinh Huu, Nam, Nguyen Minh, Hung, Hoang Vu, Son, Nguyen Thai, Anh, Do Tuan, Tuyen, Hoang Tien, Tien, Tran Viet, Quyet, Do, Van Tong, Hoang, Hoan, Nghiem Xuan, Song, Le Huu, Pallerla, Srinivas Reddy, Gostner, Johanna M., Fuchs, Dietmar, Velavan, Thirumalaisamy P.

“…•Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus (DENV) patients and subsequently decreased after recovery.•Neopterin…”
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Positive Effects of Probiotic Therapy in Patients with Post-Infectious Fatigue by Obermoser, Katharina, Brigo, Natascha, Schroll, Andrea, Monfort-Lanzas, Pablo, Gostner, Johanna M, Engl, Sabine, Geisler, Simon, Knoll, Miriam, Schennach, Harald, Weiss, Günter, Fuchs, Dietmar, Bellmann-Weiler, Rosa, Kurz, Katharina

“…Post-infectious fatigue is a common complication that can lead to decreased physical efficiency, depression, and impaired quality of life. Dysbiosis of the gut…”
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Pharmacological Targets of Kaempferol Within Inflammatory Pathways-A Hint Towards the Central Role of Tryptophan Metabolism by Hofer, Stefanie, Geisler, Simon, Lisandrelli, Rebecca, Nguyen Ngoc, Hieu, Ganzera, Markus, Schennach, Harald, Fuchs, Dietmar, Fuchs, Julian E, Gostner, Johanna M, Kurz, Katharina

“…The flavonoid kaempferol is almost ubiquitously contained in edible and medicinal plants and exerts a broad range of interesting pharmacological activities…”
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Tolerability of inhaled N-chlorotaurine in humans: a double-blind randomized phase I clinical study by Arnitz, Roland, Stein, Markus, Bauer, Petra, Lanthaler, Barbara, Jamnig, Herbert, Scholl-Bürgi, Sabine, Stempfl-Al-Jazrawi, Katharina, Ulmer, Hanno, Baumgartner, Bernhard, Embacher, Sabine, Geisler, Simon, Gostner, Johanna M., Müllinger, Bernhard, Kälz, Beate, Nagl, Markus

“…Background: N-chlorotaurine (NCT), a long-lived oxidant produced by human leukocytes, can be synthesized chemically and used topically as a well-tolerated…”
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Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio by Geisler Simon, Gostner Johanna M., Becker Kathrin, Ueberall Florian, Fuchs Dietmar

“…The proinflammatory cytokine interferon (IFN) γ activates GTP-cyclohydrolase I. In turn, the production of neopterin in human monocytic cells and of…”
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Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine-to-tyrosine ratios by Mangge Harald, Schnedl Wolfgang J., Schröcksnadel Sebastian, Geisler Simon, Murr Christian, Fuchs Dietmar

“…Higher serum neopterin concentrations and kynurenine-to-tryptophan (Kyn/Trp) ratios are associated with increased mortality in patients with coronary artery…”
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Modulation of phenylalanine and tyrosine concentrations by ischemia and guanosine in neuronal PC12 cells by Thauerer Bettina, Geisler Simon, Fuchs Dietmar, Baier-Bitterlich Gabriele

“…Survival of neurons is dependent on the presence of trophic and non-trophic factors. We have previously observed the protective capacity of purine nucleosides…”
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Better, Faster Small Hazard Detection: Instance-Aware Techniques, Metrics and Benchmarking by Geisler, Simon, Cunha, Carlos, Satzoda, Ravi Kumar

“…Vision-based detection of hazards in the path of ego-vehicle is a challenging task because of the variability in the type of hazards. In this paper, we present…”
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Elevated fecal calprotectin in patients with Alzheimer’s dementia indicates leaky gut by Leblhuber, Friedrich, Geisler, Simon, Steiner, Kostja, Fuchs, Dietmar, Schütz, Burkhard

“…Fecal concentrations of calprotectin were examined in 22 patients with Alzheimer’s disease (AD) and compared with serum concentrations of aromatic amino acids…”
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Immune activation in patients with Alzheimer's disease is associated with high serum phenylalanine concentrations by Wissmann, Philipp, Geisler, Simon, Leblhuber, Friedrich, Fuchs, Dietmar

“…Abstract Background Immune activation and inflammation represent critical factors in the pathogenesis of Alzheimer's disease (AD) and are associated with…”
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Tryptophan‐kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation by Mechtcheriakov, Sergei, Gleissenthall, Gabriele V., Geisler, Simon, Arnhard, Kathrin, Oberacher, Herbert, Schurr, Timo, Kemmler, Georg, Unterberger, Christine, Fuchs, Dietmar

“…Background Recent research has suggested that excessive alcohol consumption in patients with alcohol use disorder (AUD) is associated with chronic immune…”
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Simultaneous measurement of phenylalanine and tyrosine by high performance liquid chromatography (HPLC) with fluorescence detection by Neurauter, Gabriele, Scholl-Bürgi, Sabine, Haara, Astrid, Geisler, Simon, Mayersbach, Peter, Schennach, Harald, Fuchs, Dietmar

“…An HPLC method was developed to quantify serum concentrations of phenylalanine and tyrosine simultaneously using fluorescence detection without derivatization…”
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High indoleamine-2,3-dioxygenase 1 (IDO) activity is linked to primary resistance to immunotherapy in non-small cell lung cancer (NSCLC) by Kocher, Florian, Amann, Arno, Zimmer, Kai, Geisler, Simon, Fuchs, Dietmar, Pichler, Renate, Wolf, Dominik, Kurz, Katharina, Seeber, Andreas, Pircher, Andreas

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Modulation of the tryptophan-kynurenine axis by volatile organic compounds by Gostner, Johanna, Fagundes, Pasqualla, Geisler, Simon, Stonig, Marlies, Weiss, Günter, Fuchs, Dietmar

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Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report by Reininghaus, Eva Z, McIntyre, Roger S, Reininghaus, Bernd, Geisler, Simon, Bengesser, Susanne A, Lackner, Nina, Hecht, Karen, Birner, Armin, Kattnig, Fabian, Unterweger, Renate, Kapfhammer, Hans-Peter, Zelzer, Sieglinde, Fuchs, Dietmar, Mangge, Harald

“…Objectives Individuals with bipolar disorder (BD) are disproportionately affected by symptoms of being overweight and metabolic syndrome when compared to the…”
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