Search Results - "Simon, David J."

iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging by Renier, Nicolas, Wu, Zhuhao, Simon, David J, Yang, Jing, Ariel, Pablo, Tessier-Lavigne, Marc

“…The visualization of molecularly labeled structures within large intact tissues in three dimensions is an area of intense focus. We describe a simple, rapid,…”
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Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit by Yang, Jing, Wu, Zhuhao, Renier, Nicolas, Simon, David J., Uryu, Kunihiro, Park, David S., Greer, Peter A., Tournier, Cathy, Davis, Roger J., Tessier-Lavigne, Marc

“…Axonal death disrupts functional connectivity of neural circuits and is a critical feature of many neurodegenerative disorders. Pathological axon degeneration…”
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Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis by Sun, Lu O., Mulinyawe, Sara B., Collins, Hannah Y., Ibrahim, Adiljan, Li, Qingyun, Simon, David J., Tessier-Lavigne, Marc, Barres, Ben A.

“…Nervous system function depends on proper myelination for insulation and critical trophic support for axons. Myelination is tightly regulated spatially and…”
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Gender differential in low psychological health and low subjective well-being among older adults in India: With special focus on childless older adults by Patel, Ratna, Marbaniang, Strong P, Srivastava, Shobhit, Kumar, Pradeep, Chauhan, Shekhar, Simon, David J

“…Gender and health are two factors that shape the quality of life in old age. Previous available literature established an associaton between various…”
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Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling by Simon, David J., Pitts, Jason, Hertz, Nicholas T., Yang, Jing, Yamagishi, Yuya, Olsen, Olav, Tešić Mark, Milica, Molina, Henrik, Tessier-Lavigne, Marc

“…During development, sensory axons compete for limiting neurotrophic support, and local neurotrophin insufficiency triggers caspase-dependent axon degeneration…”
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Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species by He, Jiang, Zhou, Ruobo, Wu, Zhuhao, Carrasco, Monica A., Kurshan, Peri T., Farley, Jonathan E., Simon, David J., Wang, Guiping, Han, Boran, Hao, Junjie, Heller, Evan, Freeman, Marc R., Shen, Kang, Maniatis, Tom, Tessier-Lavigne, Marc, Zhuang, Xiaowei

“…Actin, spectrin, and associated molecules form a periodic, submembrane cytoskeleton in the axons of neurons. For a better understanding of this…”
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A caspase cascade regulating developmental axon degeneration by Simon, David J, Weimer, Robby M, McLaughlin, Todd, Kallop, Dara, Stanger, Karen, Yang, Jing, O'Leary, Dennis D M, Hannoush, Rami N, Tessier-Lavigne, Marc

“…Axon degeneration initiated by trophic factor withdrawal shares many features with programmed cell death, but many prior studies discounted a role for caspases…”
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An axon-T cell feedback loop enhances inflammation and axon degeneration by Liu, Tingting, Wang, Huanhuan, Kutsovsky, Daniel Y., Iskols, Michael, Chen, Hongjie, Ohn, Christine Y.J., Patel, Nandan, Yang, Jing, Simon, David J.

“…Inflammation is closely associated with many neurodegenerative disorders. Yet, whether inflammation causes, exacerbates, or responds to neurodegeneration has…”
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Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway by Gu, Zirong, Koppel, Natasha, Kalamboglas, John, Alexandrou, Gabriella, Li, Jie, Craig, Corey, Simon, David J, Tessier-Lavigne, Marc, Baccei, Mark L, Martin, John H, Yoshida, Yutaka

“…Axon guidance molecules and neuronal activity have been implicated in the establishment and refinement of neural circuits during development. It is unclear,…”
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Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration by Wang, Guiping, Simon, David J, Wu, Zhuhao, Belsky, Deanna M, Heller, Evan, O'Rourke, Melanie K, Hertz, Nicholas T, Molina, Henrik, Zhong, Guisheng, Tessier-Lavigne, Marc, Zhuang, Xiaowei

“…Axon degeneration sculpts neuronal connectivity patterns during development and is an early hallmark of several adult-onset neurodegenerative disorders…”
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Shall androids dream of genocides? How generative AI can change the future of memorialization of mass atrocities by Makhortykh, Mykola, Zucker, Eve M., Simon, David J., Bultmann, Daniel, Ulloa, Roberto

“…The memorialization of mass atrocities such as war crimes and genocides facilitates the remembrance of past suffering, honors those who resisted the…”
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The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions by Simon, David J., Madison, Jon M., Conery, Annie L., Thompson-Peer, Katherine L., Soskis, Michael, Ruvkun, Gary B., Kaplan, Joshua M., Kim, John K.

“…We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans neuromuscular junctions. miR-1…”
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Accumulation and Stretching of DNA Molecules in Temperature-Induced Concentration Gradients by Simon, David J., Thalheim, Tobias, Cichos, Frank

“…Temperature fields provide a noninvasive approach for manipulating individual macromolecules in solution. Utilizing thermophoresis and other secondary effects…”
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Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression by Pym, Edward, Sasidharan, Nikhil, Thompson-Peer, Katherine L, Simon, David J, Anselmo, Anthony, Sadreyev, Ruslan, Hall, Qi, Nurrish, Stephen, Kaplan, Joshua M

“…Shank is a post-synaptic scaffolding protein that has many binding partners. Shank mutations and copy number variations (CNVs) are linked to several…”
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A ciliary synapse for “short-circuit” neuromodulation by Simon, David J., Levitz, Joshua

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Sugar-free synapses run on mitochondrial Sirtuin 3 by Walsh, Alexander P, Simon, David J

“…Metabolic plasticity of neurons ensures their activity continues when glucose is limited. Walsh and Simon discuss new work by Ashrafi and colleagues…”
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A Siah3 of relief: A role for mitophagy as a fail-safe during developmental axon pruning by Davidson, Rina L, Simon, David J

“…Developmental axon pruning is controlled by a careful balance of pro- and anti-apoptotic signals, which are activated in response to external cues to sculpt…”
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Thermoplasmonic Manipulation for the Study of Single Polymers and Protein Aggregates by Simon, David J., Hartmann, Felix, Thalheim, Tobias, Cichos, Frank

“…Heat generation by means of plasmonic structures, which is at the heart of thermoplasmonics, has stimulated intense research on the manipulation of matter in…”
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p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR) by Maor-Nof, Maya, Shipony, Zohar, Lopez-Gonzalez, Rodrigo, Nakayama, Lisa, Zhang, Yong-Jie, Couthouis, Julien, Blum, Jacob A., Castruita, Patricia A., Linares, Gabriel R., Ruan, Kai, Ramaswami, Gokul, Simon, David J., Nof, Aviv, Santana, Manuel, Han, Kyuho, Sinnott-Armstrong, Nasa, Bassik, Michael C., Geschwind, Daniel H., Tessier-Lavigne, Marc, Attardi, Laura D., Lloyd, Thomas E., Ichida, Justin K., Gao, Fen-Biao, Greenleaf, William J., Yokoyama, Jennifer S., Petrucelli, Leonard, Gitler, Aaron D.

“…The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We…”
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Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration by Ankawa, Roi, Goldberger, Nitzan, Yosefzon, Yahav, Koren, Elle, Yusupova, Marianna, Rosner, Daniel, Feldman, Alona, Baror-Sebban, Shulamit, Buganim, Yosef, Simon, David J., Tessier-Lavigne, Marc, Fuchs, Yaron

“…Stem cells (SCs) play a key role in homeostasis and repair. While many studies have focused on SC self-renewal and differentiation, little is known regarding…”
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