Search Results - "Simon, Anna‐Katharina"

Mechanistic roles of autophagy in hematopoietic differentiation by Riffelmacher, Thomas, Simon, Anna‐Katharina

“…Autophagy is increasingly recognized for its active role in development and differentiation. In particular, its role in the differentiation of hematopoietic…”
Get full text

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival by Pike, Luke R G, Singleton, Dean C, Buffa, Francesca, Abramczyk, Olga, Phadwal, Kanchan, Li, Ji-Liang, Simon, Anna Katharina, Murray, James T, Harris, Adrian L

“…Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells…”
Get more information

Autophagy in the renewal, differentiation and homeostasis of immune cells by Clarke, Alexander J., Simon, Anna Katharina

“…Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly,…”
Get full text

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence by Zhang, Hanlin, Alsaleh, Ghada, Feltham, Jack, Sun, Yizhe, Napolitano, Gennaro, Riffelmacher, Thomas, Charles, Philip, Frau, Lisa, Hublitz, Philip, Yu, Zhanru, Mohammed, Shabaz, Ballabio, Andrea, Balabanov, Stefan, Mellor, Jane, Simon, Anna Katharina

“…Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of…”
Get full text

Autophagy in the immune system by Puleston, Daniel J., Simon, Anna Katharina

“…Summary Autophagy is an intracellular homeostatic mechanism important for the degradation of waste components from the cytoplasm in acidic lysosomal…”
Get full text

Autophagy takes it all - autophagy inducers target immune aging by Zinecker, Heidi, Simon, Anna Katharina

“…Autophagy, as the key nutrient recycling pathway, enables eukaryotic cells to adapt to surging cellular stress during aging and, thereby, delays age-associated…”
Get full text

B1a B cells require autophagy for metabolic homeostasis and self-renewal by Clarke, Alexander J, Riffelmacher, Thomas, Braas, Daniel, Cornall, Richard J, Simon, Anna Katharina

“…Specific metabolic programs are activated by immune cells to fulfill their functional roles, which include adaptations to their microenvironment. B1 B cells…”
Get full text

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation by Riffelmacher, Thomas, Clarke, Alexander, Richter, Felix C., Stranks, Amanda, Pandey, Sumeet, Danielli, Sara, Hublitz, Philip, Yu, Zhanru, Johnson, Errin, Schwerd, Tobias, McCullagh, James, Uhlig, Holm, Jacobsen, Sten Eirik W., Simon, Anna Katharina

“…Neutrophils are critical and short-lived mediators of innate immunity that require constant replenishment. Their differentiation in the bone marrow requires…”
Get full text

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development by Clarke, Alexander J, Ellinghaus, Ursula, Cortini, Andrea, Stranks, Amanda, Simon, Anna Katharina, Botto, Marina, Vyse, Timothy J

“…Autophagy has emerged as a critical homeostatic mechanism in T lymphocytes, influencing proliferation and differentiation. Autophagy in B cells has been less…”
Get more information

Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation by Mortensen, Monika, Watson, Alexander Scarth, Simon, Anna Katharina

“…The regulated lysosomal degradation pathway of autophagy prevents cellular damage and thus protects from malignant transformation. Autophagy is also required…”
Get full text

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses by Alsaleh, Ghada, Panse, Isabel, Swadling, Leo, Zhang, Hanlin, Richter, Felix Clemens, Meyer, Alain, Lord, Janet, Barnes, Eleanor, Klenerman, Paul, Green, Christopher, Simon, Anna Katharina

“…Vaccines are powerful tools to develop immune memory to infectious diseases and prevent excess mortality. In older adults, however vaccines are generally less…”
Get full text

Autophagy is a critical regulator of memory CD8(+) T cell formation by Puleston, Daniel J, Zhang, Hanlin, Powell, Timothy J, Lipina, Elina, Sims, Stuart, Panse, Isabel, Watson, Alexander S, Cerundolo, Vincenzo, Townsend, Alain Rm, Klenerman, Paul, Simon, Anna Katharina

“…During infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that…”
Get full text

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance by Mortensen, Monika, Soilleux, Elizabeth J, Djordjevic, Gordana, Tripp, Rebecca, Lutteropp, Michael, Sadighi-Akha, Elham, Stranks, Amanda J, Glanville, Julie, Knight, Samantha, Jacobsen, Sten-Eirik W, Kranc, Kamil R, Simon, Anna Katharina

“…The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs)…”
Get full text

Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia by Watson, Alexander Scarth, Mortensen, Monika, Simon, Anna Katharina

“…Autophagy is a conserved cellular pathway responsible for the sequestration of spent organelles and protein aggregates from the cytoplasm and their delivery…”
Get full text

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells by Smith, Amy M., Depp, Constanze, Ryan, Brent J., Johnston, Geoffrey I., Alegre‐Abarrategui, Javier, Evetts, Samuel, Rolinski, Michal, Baig, Fahd, Ruffmann, Claudio, Simon, Anna Katharina, Hu, Michele T. M., Wade‐Martins, Richard

“…ABSTRACT Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To…”
Get full text

Essential role for autophagy during invariant NKT cell development by Salio, Mariolina, Puleston, Daniel J, Mathan, Till S M, Shepherd, Dawn, Stranks, Amanda J, Adamopoulou, Eleni, Veerapen, Natacha, Besra, Gurdyal S, Hollander, Georg A, Simon, Anna Katharina, Cerundolo, Vincenzo

“…Significance Autophagy is an evolutionarily conserved catabolic process essential to maintaining cellular homeostasis through the breakdown and recycling of…”
Get full text

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation by Kabat, Agnieszka M, Harrison, Oliver J, Riffelmacher, Thomas, Moghaddam, Amin E, Pearson, Claire F, Laing, Adam, Abeler-Dörner, Lucie, Forman, Simon P, Grencis, Richard K, Sattentau, Quentin, Simon, Anna Katharina, Pott, Johanna, Maloy, Kevin J

“…A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy…”
Get full text

Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty by Lechuga-Vieco, Ana Victoria, Latorre-Pellicer, Ana, Calvo, Enrique, Torroja, Carlos, Pellico, Juan, Acín-Pérez, Rebeca, García-Gil, María Luisa, Santos, Arnoldo, Bagwan, Navratan, Bonzon-Kulichenko, Elena, Magni, Ricardo, Benito, Marina, Justo-Méndez, Raquel, Simon, Anna Katharina, Sánchez-Cabo, Fátima, Vázquez, Jesús, Ruíz-Cabello, Jesús, Enríquez, José Antonio

“…In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of…”
Get full text

Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection by Jabir, Majid Sakhi, Ritchie, Neil D., Li, Dong, Bayes, Hannah K., Tourlomousis, Panagiotis, Puleston, Daniel, Lupton, Alison, Hopkins, Lee, Simon, Anna Katharina, Bryant, Clare, Evans, Thomas J.

“…Bacterial infection can trigger autophagy and inflammasome activation, but the effects of inflammasome activation on autophagy are unknown. We examined this in…”
Get full text

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation by Zhou, Dingxi, Borsa, Mariana, Puleston, Daniel J., Zellner, Susanne, Capera, Jesusa, Sanderson, Sharon, Schifferer, Martina, Hester, Svenja S., Ge, Xin, Fischer, Roman, Jostins, Luke, Behrends, Christian, Alsaleh, Ghada, Simon, Anna Katharina

“…CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies…”
Get full text