Search Results - "Simon, Amy R"

Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria by Balwani, Manisha, Sardh, Eliane, Ventura, Paolo, Peiró, Paula Aguilera, Rees, David C, Stölzel, Ulrich, Bissell, D. Montgomery, Bonkovsky, Herbert L, Windyga, Jerzy, Anderson, Karl E, Parker, Charles, Silver, Samuel M, Keel, Siobán B, Wang, Jiaan-Der, Stein, Penelope E, Harper, Pauline, Vassiliou, Daphne, Wang, Bruce, Phillips, John, Ivanova, Aneta, Langendonk, Janneke G, Kauppinen, Raili, Minder, Elisabeth, Horie, Yutaka, Penz, Craig, Chen, Jihong, Liu, Shangbin, Ko, John J, Sweetser, Marianne T, Garg, Pushkal, Vaishnaw, Akshay, Kim, Jae B, Simon, Amy R, Gouya, Laurent

“…In a randomized phase 3 trial involving patients with acute intermittent porphyria, the use of givosiran, an oligonucleotide drug designed to target messenger…”
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Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria by Sardh, Eliane, Harper, Pauline, Balwani, Manisha, Stein, Penelope, Rees, David, Bissell, D. Montgomery, Desnick, Robert, Parker, Charles, Phillips, John, Bonkovsky, Herbert L, Vassiliou, Daphne, Penz, Craig, Chan-Daniels, Amy, He, Qiuling, Querbes, William, Fitzgerald, Kevin, Kim, Jae B, Garg, Pushkal, Vaishnaw, Akshay, Simon, Amy R, Anderson, Karl E

“…Acute intermittent porphyria results in excess activity of ALA synthase and overproduction of neurotoxic metabolites that cause attacks of severe abdominal…”
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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia by Sehgal, Alfica, Barros, Scott, Ivanciu, Lacramioara, Cooley, Brian, Qin, June, Racie, Tim, Hettinger, Julia, Carioto, Mary, Jiang, Yongfeng, Brodsky, Josh, Prabhala, Harsha, Zhang, Xuemei, Attarwala, Husain, Hutabarat, Renta, Foster, Don, Milstein, Stuart, Charisse, Klaus, Kuchimanchi, Satya, Maier, Martin A, Nechev, Lubo, Kandasamy, Pachamuthu, Kel'in, Alexander V, Nair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Meyers, Rachel, Sorensen, Benny, Simon, Amy R, Dargaud, Yesim, Negrier, Claude, Camire, Rodney M, Akinc, Akin

“…An siRNA targeting antithrombin promotes hemostasis in mouse and nonhuman primate models of hemophilia and could represent a new therapeutic option for this…”
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ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients by Gottlieb, Jens, MD, Zamora, Martin R., MD, Hodges, Tony, MD, Musk, A.W., MD, Sommerwerk, Urte, MD, Dilling, Daniel, MD, FACP, Arcasoy, Selim, MD, DeVincenzo, John, MD, Karsten, Verena, PhD, Shah, Shaily, Bettencourt, Brian R., PhD, Cehelsky, Jeffrey, MBA, Nochur, Sara, PhD, Gollob, Jared, MD, Vaishnaw, Akshay, MD, Simon, Amy R., MD, Glanville, Allan R., MD, MBBS

“…Background Respiratory syncytial virus (RSV) infection in lung transplant (LTx) patients is associated with an increased incidence of bronchiolitis obliterans…”
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Airway Epithelial STAT3 Is Required for Allergic Inflammation in a Murine Model of Asthma by Simeone-Penney, Marina C, Severgnini, Mariano, Tu, Powen, Homer, Robert J, Mariani, Thomas J, Cohn, Lauren, Simon, Amy R

“…The STAT3 transcription factor is critical for cytokine signaling and the acute phase response, but its role in allergic asthma is largely undefined. To…”
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Activation of the JAK-STAT pathway by reactive oxygen species by Simon, A R, Rai, U, Fanburg, B L, Cochran, B H

“…Reactive oxygen species (ROS) play an important role in the pathogenesis of many human diseases, including the acute respiratory distress syndrome, Parkinson's…”
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PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1 by Simeone-Penney, Marina C, Severgnini, Mariano, Rozo, Lilliana, Takahashi, Satoe, Cochran, Brent H, Simon, Amy R

“…The signal transducers and activators of transcription (STAT) family of transcription factors regulates a variety of biological functions including cellular…”
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Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis by Kim, Yuri, Ma, Ai-Guo, Kitta, Kazumi, Fitch, Sarah N, Ikeda, Takayuki, Ihara, Yoshiharu, Simon, Amy R, Evans, Todd, Suzuki, Yuichiro J

“…Anthracyclines are effective cancer chemotherapeutic agents but can induce serious cardiotoxicity. Understanding the mechanism of cardiac damage by these…”
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Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria by Agarwal, Sagar, Simon, Amy R., Goel, Varun, Habtemariam, Bahru A., Clausen, Valerie A., Kim, Jae B., Robbie, Gabriel J.

“…Givosiran is a small interfering ribonucleic acid agent that was recently approved in the United States for the treatment of acute hepatic porphyria (AHP)…”
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Activation of the STAT pathway in acute lung injury by Severgnini, Mariano, Takahashi, Satoe, Rozo, Liliana M, Homer, Robert J, Kuhn, Charles, Jhung, Jhung W, Perides, George, Steer, Michael, Hassoun, Paul M, Fanburg, Barry L, Cochran, Brent H, Simon, Amy R

“…Acute lung injury (ALI) is a devastating clinical problem with a mortality as high as 60%. It is now appreciated that ALI represents a cytokine excess state…”
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Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury by Severgnini, Mariano, Takahashi, Satoe, Tu, Powen, Perides, George, Homer, Robert J, Jhung, Jhung W, Bhavsar, Deepa, Cochran, Brent H, Simon, Amy R

“…The cascade of cellular and molecular pathways mediating acute lung injury is complex and incompletely defined. Although the Src and Jak family of kinases is…”
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Regulation of STAT3 by Direct Binding to the Rac1 GTPase by Simon, Amy R., Vikis, Haris G., Stewart, Scott, Fanburg, Barry L., Cochran, Brent H., Guan, Kun-Liang

“…The signal transducers and activators of transcription (STAT) transcription factors become phosphorylated on tyrosine and translocate to the nucleus after…”
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Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells by Simon, Amy R, Takahashi, Satoe, Severgnini, Mariano, Fanburg, Barry L, Cochran, Brent H

“…Airway remodeling, as manifested by an increase in airway smooth muscle mass, mucous gland hyperplasia, and subepithelial fibrosis, contributes to the airway…”
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GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38 by Zhong, Jian, Gavrilescu, L. Cristina, Molnár, Árpád, Murray, Lauren, Garafalo, Stephen, Kehrl, John H, Simon, Amy R, Van Etten, Richard A, Kyriakis, John M

“…Systemic inflammation arising from the organismal distribution of pathogen-associated molecular patterns is a major cause of clinical morbidity and mortality…”
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A Drug‐Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver by Vassiliou, Daphne, Sardh, Eliane, Harper, Pauline, Simon, Amy R., Clausen, Valerie A., Najafian, Nader, Robbie, Gabriel J., Agarwal, Sagar

“…Givosiran (trade name GIVLAARI) is a small interfering ribonucleic acid that targets hepatic delta‐aminolevulinic acid synthase 1 (ALAS1) messenger RNA for…”
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Normal reference ranges for urinary δ‐aminolevulinic acid and porphobilinogen levels by Agarwal, Sagar, Habtemarium, Bahru, Xu, Yuanxin, Simon, Amy R., Kim, Jae B., Robbie, Gabriel J.

“…Acute hepatic porphyria (AHP) is a family of rare, serious, and potentially life‐threatening metabolic disorders caused by mutations in genes encoding enzymes…”
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Retraction for Zhong et al., GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38 by Gavrilescu, L Cristina, Molnár, Árpád, Murray, Lauren, Garafalo, Stephen, Kehrl, John H, Simon, Amy R, Van Etten, Richard A, Kyriakis, John M

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5-HT induction of c-fos gene expression requires reactive oxygen species and Rac1 and Ras GTPases by Simon, Amy R, Severgnini, Mariano, Takahashi, Satoe, Rozo, Liliana, Andrahbi, Bathsheeba, Agyeman, Abena, Cochran, Brent H, Day, Regina M, Fanburg, Barry L

“…Serotonin (5-HT) stimulates superoxide release, phosphorylation of p42/p44 mitogen-activated protein kinase (MAPK), and DNA synthesis in bovine pulmonary…”
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RETRACTED: GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38 by Zhong, Jian, Gavrilescu, L. Cristina, Molnár, Árpád, Murray, Lauren, Garafalo, Stephen, Kehrl, John H., Simon, Amy R., Van Etten, Richard A., Kyriakis, John M.

“…Systemic inflammation arising from the organismal distribution of pathogen-associated molecular patterns is a major cause of clinical morbidity and mortality…”
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Management of venous thromboembolic disease in the chronically critically ill patient by Tanios, M A, Simon, A R, Hassoun, P M

“…Although PE is the most common preventable cause of death among U.S. hospital patients, proper treatment of thromboembolism and adequate prophylaxis in…”
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