Search Results - "Simms, Patricia E."

Characterization of Uptake and Internalization of Exosomes by Bladder Cancer Cells by Franzen, Carrie A., Simms, Patricia E., Van Huis, Adam F., Foreman, Kimberly E., Kuo, Paul C., Gupta, Gopal N.

“…Bladder tumors represent a special therapeutic challenge as they have a high recurrence rate requiring repeated interventions and may progress to invasive or…”
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HAI-1 is an independent predictor of lung cancer mortality and is required for M1 macrophage polarization by Borowicz, Stanley, Principe, Daniel R, Dorman, Matthew J, McHenry, Austin J, Sondarva, Gautam, Kumar, Sandeep, Ananthanarayanan, Vijayalakshmi, Simms, Patricia E, Hess, Ashley, Rana, Ajay

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Though immune checkpoint inhibitors (ICIs) have revolutionized lung…”
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Comparative exploration of multidimensional flow cytometry software: a model approach evaluating T cell polyfunctional behavior by Spear, Timothy T., Nishimura, Michael I., Simms, Patricia E.

“…Applications of available multidimensional flow cytometry software are compared to determine which are most appropriate to portray complex datasets using T…”
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TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors by Spear, Timothy T., Callender, Glenda G., Roszkowski, Jeffrey J., Moxley, Kelly M., Simms, Patricia E., Foley, Kendra C., Murray, David C., Scurti, Gina M., Li, Mingli, Thomas, Justin T., Langerman, Alexander, Garrett-Mayer, Elizabeth, Zhang, Yi, Nishimura, Michael I.

“…The success in recent clinical trials using T cell receptor (TCR)-genetically engineered T cells to treat melanoma has encouraged the use of this approach…”
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Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells by Spear, Timothy T., Wang, Yuan, Smith, Thomas W., Simms, Patricia E., Garrett-Mayer, Elizabeth, Hellman, Lance M., Baker, Brian M., Nishimura, Michael I.

“…The use of T cell receptor (TCR) gene-modified T cells in adoptive cell transfer has had promising clinical success, but often, simple preclinical evaluation…”
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Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells by Spear, Timothy T., Wang, Yuan, Foley, Kendra C., Murray, David C., Scurti, Gina M., Simms, Patricia E., Garrett-Mayer, Elizabeth, Hellman, Lance M., Baker, Brian M., Nishimura, Michael I.

“…T-cell receptor (TCR)-pMHC affinity has been generally accepted to be the most important factor dictating antigen recognition in gene-modified T-cells. As…”
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Hepatitis C virus‐cross‐reactive TCR gene‐modified T cells: a model for immunotherapy against diseases with genomic instability by Spear, Timothy T., Riley, Timothy P., Lyons, Gretchen E., Callender, Glenda G., Roszkowski, Jeffrey J., Wang, Yuan, Simms, Patricia E., Scurti, Gina M., Foley, Kendra C., Murray, David C., Hellman, Lance M., McMahan, Rachel H., Iwashima, Makio, Garrett‐Mayer, Elizabeth, Rosen, Hugo R., Baker, Brian M., Nishimura, Michael I.

“…Gene transfer of cross‐reactive TCRs confers CD8‐independent recognition of mutant and clinically relevant HCV epitopes; a model for T cell‐based…”
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Abstract 5514: Loss of hepatocyte growth factor activator inhibitor type-1 (HAI-1) in human lung adenocarcinomas promotes RON receptor phosphorylation and increased sensitivity to crizotinib by McHenry, Austin J., Sondarva, Gautam, Ananthanarayanan, Vijayalakshmi, Hess, Ashley, Simms, Patricia E., Alsayed, Alhareth, Kataoka, Hiroaki, Marusarz, Jan, Kumar, Sandeep, Salgia, Ravi, Dudek, Arkadiusz, Borowicz, Stanley, Rana, Ajay

“…Abstract Introduction: Non-small cell lung cancer (NSCLC) is the top cause of cancer-related mortality. We have identified a role for the tumor suppressor…”
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Hepatitis C virus-cross-reactive TCR gene-modified T cells: A model for immunotherapy against diseases with genomic instability by Spear, Timothy T, Riley, Timothy, Foley, Kendra C, Murray, David C, Simms, Patricia E, Scurti, Gina M, Wang, Yuan, Hellman, Lance M, McMahan, Rachel H, Rosen, Hugo R, Baker, Brian M, Nishimura, Michael I

“…Abstract A major obstacle hindering the development of effective immunity against viral infections, their associated disease, and certain cancers is their…”
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Identification of a novel CD56- lymphokine-activated killer cell precursor in cancer patients receiving recombinant interleukin 2 by MCKENZIE, R. S, SIMMS, P. E, HELFRICH, B. A, FISHER, R. I, ELLIS, T. M

“…Circulating lymphokine-activated killer (LAK) cell activity in cancer patients receiving recombinant interleukin 2 (rIL-2) therapy is confined to cells…”
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Utility of flow cytometric detection of CD69 expression as a rapid method for determining poly- and oligoclonal lymphocyte activation by Simms, P E, Ellis, T M

“…CD69 is a lymphoid activation antigen whose rapid expression (< or = 2 h postactivation) makes it amenable for the early detection of T-cell activation and for…”
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CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO+ T cells by Ellis, TM, Simms, PE, Slivnick, DJ, Jack, HM, Fisher, RI

“…CD30 has been extensively studied as a cell surface marker expressed by Reed-Sternberg cells of Hodgkin's disease and other hematologic malignancies, although…”
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Interleukin-12 activates interferon-gamma production by targeted activation of CD30+ T cells by Alzona, M, Jäck, H M, Simms, P E, Ellis, T M

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Transplacentally acquired caffeine and the occurrence of apnea, bradycardia, and periodic breathing in preterm infants: preliminary communication by McCulloch, K M, Braun, R J, Simms, P E, Evans, M A, Kelly, D H

“…Cord blood caffeine concentrations were measured by high-pressure liquid chromatography in 79 preterm infants. Eleven infants (14%) had detectable caffeine…”
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