Search Results - "Simms, Jeffrey A."

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake by Seif, Taban, Chang, Shao-Ju, Simms, Jeffrey A, Gibb, Stuart L, Dadgar, Jahan, Chen, Billy T, Harvey, Brandon K, Ron, Dorit, Messing, Robert O, Bonci, Antonello, Hopf, F Woodward

“…The authors show that optogenetic inhibition of inputs from medial prefrontal cortex (mPFC) or insula to the nucleus accumbens core (NAcore) inhibits…”
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Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking by Steensland, Pia, Simms, Jeffrey A, Holgate, Joan, Richards, Jemma K, Bartlett, Selena E

“…Alcohol dependence is a disease that impacts millions of individuals worldwide. There has been some progress with pharmacotherapy for alcohol-dependent…”
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Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats by Richards, Jemma K., Simms, Jeffrey A., Steensland, Pia, Taha, Sharif A., Borgland, Stephanie L., Bonci, Antonello, Bartlett, Selena E.

“…Rationale Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and…”
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The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration by Srinivasan, Subhashini, Simms, Jeffrey A, Nielsen, Carsten K, Lieske, Steven P, Bito-Onon, Jade J, Yi, Henry, Hopf, Frederic Woodward, Bonci, Antonello, Bartlett, Selena E

“…Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor…”
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Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats by Landgren, Sara, Simms, Jeffrey A., Hyytiä, Petri, Engel, Jörgen A., Bartlett, Selena E., Jerlhag, Elisabet

“…ABSTRACT The mechanisms involved in alcohol use disorders are complex. It has been shown that ghrelin is an important signal for the control of body weight…”
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Happyhour, a Ste20 Family Kinase, Implicates EGFR Signaling in Ethanol-Induced Behaviors by Corl, Ammon B., Berger, Karen H., Ophir-Shohat, Galit, Gesch, Julie, Simms, Jeffrey A., Bartlett, Selena E., Heberlein, Ulrike

“…The consequences of alcohol use disorders (AUDs) are devastating to individuals and society, yet few treatments are currently available. To identify genes…”
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The ghrelin signalling system is involved in the consumption of sweets by Landgren, Sara, Simms, Jeffrey A, Thelle, Dag S, Strandhagen, Elisabeth, Bartlett, Selena E, Engel, Jörgen A, Jerlhag, Elisabet

“…The gastric-derived orexigenic peptide ghrelin affects brain circuits involved in energy balance as well as in reward. Indeed, ghrelin activates an important…”
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Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors by Feduccia, Allison A., Wang, Yuanyuan, Simms, Jeffrey A., Yi, Henry Y., Li, Rui, Bjeldanes, Leonard, Ye, Chuangxing, Bartlett, Selena E.

“…Purine compounds, such as caffeine, have many health-promoting properties and have proven to be beneficial in treating a number of different conditions…”
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Fischer rats consume 20% ethanol in a long-term intermittent-access two-bottle-choice paradigm by Mill, Douglas J, Bito-Onon, Jade J, Simms, Jeffrey A, Li, Rui, Bartlett, Selena E

“…The 20% ethanol intermittent-access (IAE) two-bottle-choice drinking procedure has been shown to produce high voluntary ethanol consumption in a number of rat…”
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The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol by Steensland, Pia, Simms, Jeffrey A, Nielsen, Carsten K, Holgate, Joan, Bito-Onon, Jade J, Bartlett, Selena E

“…The current obesity epidemic is thought to be partly driven by over-consumption of sugar-sweetened diets and soft drinks. Loss-of-control over eating and…”
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D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats by Seif, Taban, Simms, Jeffrey A, Lei, Kelly, Wegner, Scott, Bonci, Antonello, Messing, Robert O, Hopf, F Woodward

“…There is considerable interest in NMDAR modulators to enhance memory and treat neuropsychiatric disorders such as addiction, depression, and schizophrenia…”
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Intermittent Access to 20% Ethanol Induces High Ethanol Consumption in Long-Evans and Wistar Rats by Simms, Jeffrey A., Steensland, Pia, Medina, Brian, Abernathy, Kenneth E., Chandler, L. Judson, Wise, Roy, Bartlett, Selena E.

“…Background:  There has been some difficulty getting standard laboratory rats to voluntarily consume large amounts of ethanol without the use of initiation…”
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Mifepristone in the Central Nucleus of the Amygdala Reduces Yohimbine Stress-Induced Reinstatement of Ethanol-Seeking by SIMMS, Jeffrey A, HAASS-KOFFLER, Carolina L, BITO-ONON, Jade, RUI LI, BARTLETT, Selena E

“…Chronic ethanol exposure leads to dysregulation of the hypothalamic-pituitary-adrenal axis, leading to changes in glucocorticoid release and function that have…”
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Long-Evans Rats Acquire Operant Self-Administration of 20% Ethanol Without Sucrose Fading by SIMMS, Jeffrey A, BITO-ONON, Jade J, CHATTERJEE, Susmita, BARTLETT, Selena E

“…A major obstacle in the development of new medications for the treatment of alcohol use disorders (AUDs) has been the lack of preclinical, oral ethanol…”
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Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats by Bito-Onon, Jade J., Simms, Jeffrey A., Chatterjee, Susmita, Holgate, Joan, Bartlett, Selena E.

“…ABSTRACT Alcohol and nicotine use disorders are often treated as separate diseases, despite evidence that approximately 80–90% of alcohol dependent individuals…”
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Chlorzoxazone, an SK-Type Potassium Channel Activator Used in Humans, Reduces Excessive Alcohol Intake in Rats by Hopf, F. Woodward, Simms, Jeffrey A, Chang, Shao-Ju, Seif, Taban, Bartlett, Selena E, Bonci, Antonello

“…Background Alcoholism imposes a tremendous social and economic burden. There are relatively few pharmacological treatments for alcoholism, with only moderate…”
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A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice by Lei, Kelly, Wegner, Scott A, Yu, Ji-Hwan, Simms, Jeffrey A, Hopf, F. Woodward

“…Abstract Addiction is mediated in large part by pathological motivation for rewarding, addictive substances, and alcohol-use disorders (AUDs) continue to…”
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Partial Agonists of the α3β4 Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats by CHATTERJEE, Susmita, STEENSLAND, Pia, SIMMS, Jeffrey A, HOLGATE, Joan, COE, Jotham W, HURST, Raymond S, SHAFFER, Christopher L, LOWE, John, ROLLEMA, Hans, BARTLETT, Selena E

“…Alcohol use disorders (AUDs) impact millions of individuals and there remain few effective treatment strategies. Despite evidence that neuronal nicotinic…”
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Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395 by Simms, Jeffrey A., Nielsen, Carsten K., Li, Rui, Bartlett, Selena E.

“…Corticotrophin‐releasing factor (CRF) is a mediator of stress responses and a key modulator of ethanol‐mediated behaviors. We report here that the CRF receptor…”
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δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats by Nielsen, Carsten K, Simms, Jeffrey A, Li, Rui, Mill, Douglas, Yi, Henry, Feduccia, Allison A, Santos, Nathan, Bartlett, Selena E

“…Binge-like patterns of excessive drinking during young adulthood increase the propensity for alcohol use disorders (AUDs) later in adult life; however, the…”
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