Search Results - "Simms, H. Hank"

Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve by RONGQIAN WU, WEIFENG DONG, XIAOXUAN CUI, MIAN ZHOU, HANK SIMMS, H, RAVIKUMAR, Thanjavur S, PING WANG

“…To test the hypothesis that administration of ghrelin attenuates inflammatory responses in sepsis through vagal nerve stimulation. Ghrelin has been…”
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The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ by Siddiqui, Aqeel M, Cui, Xiaoxuan, Wu, Rongqian, Dong, Weifeng, Zhou, Mian, Hu, Maowen, Simms, H Hank, Wang, Ping

“…OBJECTIVE:Although phytochemical curcumin has been shown to possess anti-inflammatory properties, it remains unknown whether this agent has any beneficial…”
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Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity by Chung, Chun‐Shiang, Song, Grace Y., Lomas, Joanne, Simms, H. Hank, Chaudry, Irshad H., Ayala, Alfred

“…Signaling through the Fas/Fas ligand (FasL) pathway plays a central role in immune‐cell response and function; however, under certain pathological conditions…”
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The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis by Leuenroth, Stephanie J., Grutkoski, Patricia S., Ayala, Alfred, Simms, H. Hank

“…The regulation of polymorphonuclear leukoctye (PMN) apoptosis can influence the duration of the inflammatory response. We have previously shown that PMN…”
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Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis by Crawford, Jack H, Yang, Shaolong, Zhou, Mian, Simms, H Hank, Wang, Ping

“…OBJECTIVEAlthough hepatic cytochrome P-450 protein concentrations are altered following endotoxin shock, changes in P-450 isoforms in sepsis have not been…”
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Delayed administration of human inter-α inhibitor proteins reduces mortality in sepsis by Wu, Rongqian, Cui, Xiaoxuan, Lim, Yow-Pin, Bendelja, Kreso, Zhou, Mian, Hank Simms, H, Wang, Ping

“…OBJECTIVE:We have recently shown that administration of human inter-α inhibitor proteins (IαIp) very early after the onset of sepsis maintains cardiovascular…”
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Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats by Wu, Rongqian, Dong, Weifeng, Zhou, Mian, Simms, H Hank, Marini, Corrado P, Ravikumar, Thanjavur S, Wang, Ping

“…OBJECTIVE:Management of trauma victims with uncontrolled hemorrhage remains a major problem in combat casualty care at the far-forward battlefield setting. The…”
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Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage by Cui, Xiaoxuan, Wu, Rongqian, Zhou, Mian, Dong, Weifeng, Ulloa, Luis, Yang, Huan, Wang, Haichao, Tracey, Kevin J, Simms, H Hank, Wang, Ping

“…OBJECTIVE:The neuroendocrine response to hemorrhage is to maintain perfusion to the heart and brain, often at the expense of other organ systems. Systemic…”
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Diagnosis of acute cholecystitis: sensitivity of sonography, cholescintigraphy, and combined sonography-cholescintigraphy by Kalimi, Robert, Gecelter, Gary R., Caplin, Drew, Brickman, Michael, Tronco, Gene T., Love, Charito, Yao, Jeffery, Simms, H.Hank, Marini, Corrado P.

“…BACKGROUND: Radiographic diagnosis of acute cholecystitis can be established using ultrasonography (US), cholecystoscintigraphy (HIDA), or both. Although both…”
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Abdominal compartment syndrome in the surgical intensive care unit by Mcnelis, John, Soffer, Samuel, Marini, Corrado P, Jurkiewicz, Antoni, Ritter, Garry, Simms, H Hank, Nathan, Ira

“…The abdominal compartment syndrome (ACS) is a clinical entity that develops after sustained and uncontrolled intra-abdominal hypertension. ACS has been…”
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Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion by Carrizo, Gonzalo J., MD, Wu, Rongqian, MD, PhD, Cui, Xiaoxuan, MD, PhD, Dwivedi, Amit J., MD, Simms, H. Hank, MD, Wang, Ping, MD

“…Background Recent studies have shown that adrenomedullin (AM) and AM-binding protein-1 (AMBP-1) possess anti-inflammatory properties in sepsis. We hypothesized…”
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Tumor necrosis factor-α–stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner by Grutkoski, Patricia S, D’Amico, Ron, Ayala, Alfred, Hank Simms, H

“…OBJECTIVE Polymorphonuclear leukocytes (PMN) and tumor necrosis factor-α (TNF-α) play prominent roles in acute respiratory distress syndrome,…”
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Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma by Miksa, Michael, Wu, Rongqian, Cui, Xiaoxuan, Dong, Weifeng, Das, Padmalaya, Simms, H Hank, Ravikumar, Thanjavur S, Wang, Ping

“…Sepsis is a critical inflammatory condition from which numerous patients die due to multiple organ failure and septic shock. The vasoactive hormone…”
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Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1 by RONGQIAN WU, WEIFENG DONG, MIAN ZHOU, XIAOXUAN CUI, SIMMS, H. Hank, PING WANG

“…Severe sepsis is associated with increased total peripheral resistance (TPR) and decreased organ blood flow, in which endothelin-1 (ET-1) plays an important…”
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Adrenomedullin and adrenomedullin binding protein-1 attenuate Vascular endothelial cell apoptosis in sepsis by MIAN ZHOU, SIMMS, H. Hank, PING WANG

“…To determine whether vascular endothelial cell apoptosis occurs in the late stage of sepsis and, if so, whether administration of a potent vasodilatory peptide…”
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Shock-Induced Neutrophil Mediated Priming for Acute Lung Injury in Mice: Divergent Effects of TLR-4 and TLR-4/FasL Deficiency by Ayala, Alfred, Chung, Chun-Shiang, Lomas, Joanne L, Song, Grace Y, Doughty, Lesley A, Gregory, Stephen H, Cioffi, William G, LeBlanc, Brian W, Reichner, Jonathan, Simms, H. Hank, Grutkoski, Patricia S

“…Acute lung injury (ALI) leading to respiratory distress is a common sequela of shock/trauma, however, modeling this process in mice with a single shock or…”
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Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis by Wu, Rongqian, Zhou, Mian, Cui, Xiaoxuan, Simms, H Hank, Wang, Ping

“…Ghrelin, a newly identified endogenous ligand for growth hormone secretagogue receptor 1a (GHSR-1a, i.e., ghrelin receptor), was recently demonstrated to be a…”
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Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: The central role of proinflammatory cytokines by Wu, Rongqian, Cui, Xiaoxuan, Dong, Weifeng, Zhou, Mian, Simms, H, Wang, Ping

“…The hepatic cytochrome P-450 (CYP) enzyme system provides a major aspect of liver function, yet alterations of CYP in sepsis remain largely unknown. Although…”
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Proapoptotic effect of curcumin on human neutrophils: Activation of the p38 mitogen-activated protein kinase pathway by Hu, Maowen, Du, Qiaoting, Vancurova, Ivana, Lin, Xinchun, Miller, Edmund J, Simms, H Hank, Wang, Ping

“…OBJECTIVE:Despite advances in the management of sepsis and acute respiratory distress syndrome, the mortality rate remains high. Delayed apoptosis of…”
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Abdominal compartment syndrome: clinical manifestations and predictive factors by McNelis, John, Marini, Corrado P, Simms, H Hank

“…Abdominal compartment syndrome (ACS) is the end result of sustained, uncorrected intraabdominal hypertension. In clinical and laboratory settings, ACS has been…”
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