Search Results - "Simms, Carrie L."

Oxidation and alkylation stresses activate ribosome-quality control by Yan, Liewei L., Simms, Carrie L., McLoughlin, Fionn, Vierstra, Richard D., Zaher, Hani S.

“…Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties within RNA. It is, however, unclear whether organisms have evolved…”
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An Active Role for the Ribosome in Determining the Fate of Oxidized mRNA by Simms, Carrie L., Hudson, Benjamin H., Mosior, John W., Rangwala, Ali S., Zaher, Hani S.

“…Chemical damage to RNA affects its functional properties and thus may pose a significant hurdle to the translational apparatus; however, the effects of damaged…”
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Ribosome‐based quality control of mRNA and nascent peptides by Simms, Carrie L., Thomas, Erica N., Zaher, Hani S.

“…Quality control processes are widespread and play essential roles in detecting defective molecules and removing them in order to maintain organismal fitness…”
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Ontogeny of Circadian Rhythms and Synchrony in the Suprachiasmatic Nucleus by Carmona-Alcocer, Vania, Abel, John H, Sun, Tao C, Petzold, Linda R, Doyle, 3rd, Francis J, Simms, Carrie L, Herzog, Erik D

“…In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates daily rhythms including sleep-wake, hormone release, and gene expression. The…”
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Ribosome Collisions Result in +1 Frameshifting in the Absence of No-Go Decay by Simms, Carrie L., Yan, Liewei L., Qiu, Jessica K., Zaher, Hani S.

“…During translation, an mRNA is typically occupied by multiple ribosomes sparsely distributed across the coding sequence. This distribution, mediated by slow…”
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Uniformity of Peptide Release Is Maintained by Methylation of Release Factors by Pierson, William E., Hoffer, Eric D., Keedy, Hannah E., Simms, Carrie L., Dunham, Christine M., Zaher, Hani S.

“…Termination of protein synthesis on the ribosome is catalyzed by release factors (RFs), which share a conserved glycine-glycine-glutamine (GGQ) motif. The…”
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Interactions between the mRNA and Rps3/uS3 at the entry tunnel of the ribosomal small subunit are important for no-go decay by Simms, Carrie L, Kim, Kyusik Q, Yan, Liewei L, Qiu, Jessica, Zaher, Hani S

“…No-go Decay (NGD) is a process that has evolved to deal with stalled ribosomes resulting from structural blocks or aberrant mRNAs. The process is distinguished…”
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Distinct Firing Properties of Vasoactive Intestinal Peptide-Expressing Neurons in the Suprachiasmatic Nucleus by Hermanstyne, Tracey O., Simms, Carrie L., Carrasquillo, Yarimar, Herzog, Erik D., Nerbonne, Jeanne M.

“…The suprachiasmatic nucleus (SCN) regulates daily rhythms in physiology and behavior. Previous studies suggest a critical role for neurons expressing…”
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Ribosome Collision Is Critical for Quality Control during No-Go Decay by Simms, Carrie L., Yan, Liewei L., Zaher, Hani S.

“…No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with translational arrests. The process is characterized by an endonucleolytic…”
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Quality control of chemically damaged RNA by Simms, Carrie L., Zaher, Hani S.

“…The “central dogma” of molecular biology describes how information contained in DNA is transformed into RNA and finally into proteins. In order for proteins to…”
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A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/ egf expression to promote RAS-dependent vulval induction in C. elegans by Simms, Carrie L., Baillie, David L.

“…The specification and patterning of vulval precursor cells (VPCs) in C aenorhabditis elegans is achieved using a conserved EGFR/RAS signaling pathway that is…”
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Insights into the base-pairing preferences of 8-oxoguanosine on the ribosome by Thomas, Erica N, Simms, Carrie L, Keedy, Hannah E, Zaher, Hani S

“…Abstract Of the four bases, guanine is the most susceptible to oxidation, which results in the formation of 8-oxoguanine (8-oxoG). In protein-free DNA, 8-oxodG…”
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Ribosome‐Based Quality Control Of Chemically Damaged mRNA by Zaher, Hani, Simms, Carrie L, Hudson, Benjamin H

“…Abstract only Nucleic acids are constantly under assault from both endogenous and exogenous agents that can affect their chemical properties and hence their…”
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Uniformity of Peptide Release Is Maintained by Methylation of Release Factors by Pierson, William E., Hoffer, Eric D., Keedy, Hannah E., Simms, Carrie L., Dunham, Christine M., Zaher, Hani S.

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