Search Results - "Simmons, Sarah C."

Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits by Flerlage, William J, Langlois, Ludovic D, Rusnak, Milan, Simmons, Sarah C, Gouty, Shawn, Armstrong, Regina C, Cox, Brian M, Symes, Aviva J, Tsuda, Mumeko C, Nugent, Fereshteh S

“…Affective disorders including depression (characterized by reduced motivation, social withdrawal, and anhedonia), anxiety, and irritability are frequently…”
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Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders by Baker, Phillip M, Mathis, Victor, Lecourtier, Lucas, Simmons, Sarah C, Nugent, Fereshteh S, Hill, Sierra, Mizumori, Sheri J Y

“…In this Perspective review, we highlight some of the less explored aspects of lateral habenula (LHb) function in contextual memory, sleep, and behavioral…”
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Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula by Simmons, Sarah C., Shepard, Ryan D., Gouty, Shawn, Langlois, Ludovic D., Flerlage, William J., Cox, Brian M., Nugent, Fereshteh S.

“…The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine…”
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Determination of circuit-specific morphological adaptations in ventral tegmental area dopamine neurons by chronic morphine by Simmons, Sarah C, Wheeler, Katie, Mazei-Robison, Michelle S

“…Chronic opiate exposure induces neuroadaptations in the mesocorticolimbic system including ventral tegmental area (VTA) dopamine (DA) neurons, whose soma size…”
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Repetitive mild traumatic brain injury induces persistent alterations in spontaneous synaptic activity of hippocampal CA1 pyramidal neurons by Langlois, Ludovic D., Selvaraj, Prabhuanand, Simmons, Sarah C., Gouty, Shawn, Zhang, Yumin, Nugent, Fereshteh S.

“…Mild traumatic brain injury (mTBI) or concussion is the most common form of TBI which frequently results in persistent cognitive impairments and memory…”
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AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula by Simmons, Sarah C., Flerlage, William J., Langlois, Ludovic D., Shepard, Ryan D., Bouslog, Christopher, Thomas, Emily H., Gouty, Kaitlyn M., Sanderson, Jennifer L., Gouty, Shawn, Cox, Brian M., Dell’Acqua, Mark L., Nugent, Fereshteh S.

“…The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and…”
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Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development by Simmons, Sarah C., Grecco, Greg G., Atwood, Brady K., Nugent, Fereshteh S.

“…In this review, we focus on prenatal opioid exposure (POE) given the significant concern for the mental health outcomes of children with parents affected by…”
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Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury by Flerlage, William J., Simmons, Sarah C., Thomas, Emily H., Gouty, Shawn, Cox, Brian M., Nugent, Fereshteh S.

“…Mild traumatic brain injury (mTBI) increases the risk of affective disorders, anxiety and substance use disorder. The lateral habenula (LHb) plays an important…”
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Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self‐administration in rats by Langlois, Ludovic D., Berman, Rina Y., Shepard, Ryan D., Simmons, Sarah C., Tsuda, Mumeko C., Gouty, Shawn, Choi, Kwang H., Nugent, Fereshteh S.

“…Early life stress presents an important risk factor for drug addiction and comorbid depression and anxiety through persistent effects on the mesolimbic…”
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Characterization of proinflammatory markers in the ventral tegmental area across mouse models of chronic stress by Bali, Vedrana, Simmons, Sarah C., Manning, Claire E., Doyle, Marie A., Rodriguez, Minerva, Stark, Ali R., Ayala Rosario, Shantée N., Robison, A.J., Mazei-Robison, Michelle S.

“…•Physical, but not vicarious, social defeat stress increases IL-1β mRNA in the VTA.•Physical social defeat stress does not alter the number of Iba1- or…”
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Pubertal Testosterone Programs Adult Behavioral Adaptations to Sexual Experience through Infralimbic Cortex ΔFosB by De Lorme, Kayla C, Staffend-Michael, Nancy A, Simmons, Sarah C, Robison, Alfred J, Sisk, Cheryl L

“…Acquisition of social proficiency entails behavioral adaptations to social experience, including both behavioral flexibility and inhibition of behaviors…”
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Protracted Effects of Ketamine Require Immediate Kappa Opioid Receptor Activation and Long‐Lasting Desensitization by Jacobson, Moriah L., Simmons, Sarah C., Wulf, Hildegard A., Cheng, Huaiyan, Feng, Ying-Hong, Nugent, Fereshteh S., Browne, Caroline A., Lucki, Irwin

“…Abstract only Ketamine produces rapid and sustained antidepressant activity, but its mechanism of action remains uncertain. Williams & colleagues (2018)…”
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