Search Results - "Simmons, Michele L"

Opioid Modulation of Recurrent Excitation in the Hippocampal Dentate Gyrus by Terman, Gregory W, Drake, Carrie T, Simmons, Michele L, Milner, Teresa A, Chavkin, Charles

“…kappa opioid receptor activation inhibits granule cell-mediated excitatory neurotransmission in the hippocampal formation via a decrease in glutamate release…”
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L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells by Simmons, Michele L, Terman, Gregory W, Gibbs, Sarah M, Chavkin, Charles

“…Granule cells in the guinea pig dentate gyrus release κ opioid neuropeptides, dynorphins, from dendrites as well as from axon terminals. We have found that…”
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Kappa opioid receptor-like immunoreactivity in guinea pig brain: Ultrastructural localization in presynaptic terminals in hippocampal formation by Drake, Carrie T., Patterson, Terrell A., Simmons, Michele L., Chavkin, Charles, Milner, Teresa A.

“…Physiological and pharmacological studies have suggested that kappa opioid receptors (KORs) may be located presynaptically in the guinea pig hippocampal…”
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Spontaneous Excitatory Currents and kappa -Opioid Receptor Inhibition in Dentate Gyrus Are Increased in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Simmons, Michele L, Terman, Gregory W, Chavkin, Charles

“…Michele L. Simmons 1 , Gregory W. Terman 2 , and Charles Chavkin 1 1  Department of Pharmacology and 2  Department of Anesthesiology, University of Washington,…”
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Endogenous opioid regulation of hippocampal function by Simmons, M L, Chavkin, C

“…Endogenous opioid peptides modulate neural transmission in the hippocampus. Procnkephalin-derived peptides have been demonstrated to act at mu and delta opioid…”
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Altered Behavior and Long-Term Potentiation in Type I Adenylyl Cyclase Mutant Mice by Wu, Zhi-Liang, Thomas, Steven A., Villacres, Enrique C., Xia, Zhengui, Simmons, Michele L., Chavkin, Charles, Palmiter, Richard D., Storm, Daniel R.

“…The murine Ca2+-stimulated adenylyl cyclase (type I) (EC 4.6.1.1), which is expressed predominantly in brain, was inactivated by targeted mutagenesis…”
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Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters by Drake, CT, Terman, GW, Simmons, ML, Milner, TA, Kunkel, DD, Schwartzkroin, PA, Chavkin, C

“…The granule cell population response to perforant path stimulation decreased significantly within seconds following release of endogenous dynorphin from…”
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Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization by Slusher, B S, Robinson, M B, Tsai, G, Simmons, M L, Richards, S S, Coyle, J T

“…N-Acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase) is a membrane-bound metallopeptidase that cleaves glutamate from the endogenous neuropeptide…”
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Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus by Simmons, M L, Wagner, J J, Caudle, R M, Chavkin, C

“…Release of endogenous norepinephrine was detected in guinea pig hippocampal slices using a radioligand displacement assay. Focal electrical stimulation…”
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