Search Results - "Simmons, Jon"

Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance by Yuzefovych, Larysa V, Pastukh, Viktor M, Ruchko, Mykhaylo V, Simmons, Jon D, Richards, William O, Rachek, Lyudmila I

“…Cells damaged by mechanical or infectious injury release proinflammatory mitochondrial DNA (mtDNA) fragments into the circulation. We evaluated the relation…”
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Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects by Simmons, Jon D., Lee, Yann-Leei, Mulekar, Sujata, Kuck, Jamie L., Brevard, Sidney B., Gonzalez, Richard P., Gillespie, Mark N., Richards, William O.

“…OBJECTIVE:Our objective was to execute a prospective cohort study to determine relationships between plasma mtDNA DAMP levels and the occurrence of systemic…”
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Project Inspire pilot study: A hospital-led comprehensive intervention reduces gun violence among juveniles delinquent of gun crimes by Malone, Kaleb, Hogue, Antwan, Naman, Edmond, Graves, Curtis, Haiflich, Andrew, Simmons, Jon D., Williams, Ashley Y.

“…Gun violence disproportionately affects young Black men, but the impact extends to families and communities. Those at highest risk are teens delinquent of gun…”
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Association Between Adverse Childhood Experiences and Posttraumatic Stress Disorder Symptoms in Adults With Injury by Huffmaster, Candace E, Williams, Ashley Y, Lee, Yann-Leei L, Butts, C Caleb, Polite, Nathan M, Mehari, Krista R, Simmons, Jon D

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Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury by Lee, Yann-Leei, MD, King, Madelyn B., BS, Gonzalez, Richard P., MD, Brevard, Sidney B., MD, Frotan, M. Amin, MD, Gillespie, Mark N., PhD, Simmons, Jon D., MD

“…Abstract Background Transfusion-related acute lung injury (TRALI) is the most frequent and severe complication in patients receiving multiple blood…”
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Implementing a Discharge Opioid Bundle in Adult Trauma Patients Decreases the Amount of Opioids Prescribed at Discharge by Krebsbach, Mackenzie N, Alexander, Kaitlin M, Miller, Jennifer J, Doll, Elizabeth L, Lee, Yann-Leei, Simmons, Jon D

“…Opioids remain the mainstay treatment of acute pain caused by trauma. The lack of evidence driven prescribing creates a challenging situation for providers. We…”
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Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs by Kuck, Jamie L, Obiako, Boniface O, Gorodnya, Olena M, Pastukh, Viktor M, Kua, Justin, Simmons, Jon D, Gillespie, Mark N

“…Fragments of the mitochondrial genome released into the systemic circulation after mechanical trauma, termed mitochondrial DNA damage-associated molecular…”
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Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions by Simmons, Jon D, Lee, Yann-Leei L, Pastukh, Viktor M, Capley, Gina, Muscat, Cherry A, Muscat, David C, Marshall, Michael L, Brevard, Sidney B, Gillespie, Mark N

“…Massive transfusions are accompanied by an increased incidence of a particularly aggressive and lethal form of acute lung injury (delayed transfusion-related…”
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The safety of low molecular-weight heparin after blunt liver and spleen injuries by Rostas, Jack W., M.D, Manley, Justin, M.D, Gonzalez, Richard P., M.D, Brevard, Sidney B., M.D, Ahmed, Naveed, M.D, Frotan, Mohammad Amin, M.D, Mitchell, Ellen, M.D, Simmons, Jon D., M.D

“…Abstract Background Anticoagulation is routinely administered to all trauma patients owing to the high incidence of venous thromboembolism (VTE). However, the…”
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Deleterious effects of plasma-derived cellular debris in a porcine model of hemorrhagic shock by Buckley, Colin T., Lee, Yannleei L., Michele Schuler, A., Langley, Raymond J., Kutcher, Matthew E., Barrington, Robert, Audia, Jonathon P., Simmons, Jon D.

“…Recent studies identify large quantities of inflammatory cellular debris within Fresh Frozen Plasma (FFP). As FFP is a mainstay of hemorrhagic shock…”
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Patient Resiliency and Caregiver Burden After Traumatic Spinal Cord Injury Resulting in Quadriplegia by Howell, Caroline W, Lawrence, James A, Hinkel, Hannah M, Clutton, Caroline H, Lee, Yann-Leei L, Simmons, Jon D, Williams, Ashley Y

“…Traumatic spinal cord injury (tSCI) resulting in quadriplegia is a life-altering injury for patients and caregivers. We conducted a retrospective review of…”
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Time to Mobility Is Associated With Pulmonary Complications in Patients With Spine Fractures by Jackson, Michael L, Thomas, Samuel C, Joyner, Matthew R, Hu, Mengjie, Larry Lee, Yann-Leei, Capasso, Thomas, Polite, Nathan M, Kinnard, Christopher M, Mbaka, Maryann I, Williams, Ashley, Simmons, Jon D, Butts, Charles C

“…Treatment of spine fractures may require periods of prolonged immobilization which prevents effective pulmonary toileting. We hypothesized that patients with…”
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Diabetes in Trauma Patients: A Potential Gateway to a Medical Home by Hart, Kaylee, Thames, Margaret A, Massey, Ashley Caroline, Capasso, Thomas, Lee, Yannlei L, Mbaka, Maryann, Kinnard, Christopher M, Bright, Andrew C, Williams, Ashley Y, Polite, Nathan M, Simmons, Jon D, Butts, C Caleb

“…Diabetes is a major determinant of health outcomes. Trauma patients are disproportionately from lower socioeconomic status, where lack of access to health care…”
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Choledochal Cyst Originating From the Cystic Duct by Quang, Kenny T, Hunter, Justin L, Wilson, John W, Simmons, Jon D

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Intercostal Cryoneurolysis After Severe Chest Trauma: A Brief Report by Farley, Paige, Mullen, Parker R, Lee, Yannleei L, Caleb Butts, C, Simmons, Jon D, Brevard, Sidney B, Kinnard, Christopher M

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Monotherapy Antibiotic Prophylaxis of Lower Extremity Long Bone Type III Open Fractures by Robinson, Thomas W, Gautreaux, Corinne E, Lee, Yann-Leei L, Mbaka, Maryann, Kinnard, Christopher M, Bright, Andrew C, Williams, Ashley Y, Polite, Nathan M, Capasso, Thomas J, Simmons, Jon D, Butts, Charles C

“…Gustilo type III open fractures involve extensive soft tissue damage and wound contamination that pose significant infection risks. The historical standard for…”
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Incidence and Severity of Medication Reconciliation Discrepancies in Trauma Patients by Dunbar, Elisabeth G, Massey, Ashley C, Lee, Yannlei L, Mbaka, Maryann, Kinnard, Christopher M, Bright, Andrew C, Williams, Ashley Y, Polite, Nathan M, Simmons, Jon D, Butts, Charles C

“…Trauma patients are especially vulnerable to inadvertent medication reconciliation discrepancies. We conducted a prospective study to evaluate the USA Health…”
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Rib fractures and their association With solid organ injury: higher rib fractures have greater significance for solid organ injury screening by Rostas, Jack W., Lively, Timothy B., Brevard, Sidney B., Simmons, Jon D., Frotan, Mohammad A., Gonzalez, Richard P.

“…The purpose of this study was to identify patients with rib injuries who were at risk for solid organ injury. A retrospective chart review was performed of all…”
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Social Determinants of Health Impact Physical Recovery After Blunt Injury by Cockrell, Benjamin E, Haiflich, Andrew N, Lee, Yann-Leei L, Kinnard, Christopher M, Butts, Charles C, Polite, Nathan M, Mbaka, Maryann I, Bright, Andrew C, Simmons, Jon D, Williams, Ashley Y

“…As defined by the United States Department of Health and Human Services, the Social Determinants of Health (SDOH) are conditions in the environment that affect…”
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Prevention of all-terrain vehicle injuries: A systematic review from The Eastern Association for the Surgery of Trauma by Rattan, Rishi, Joseph, D'Andrea K, Dente, Christopher J, Klein, Eric N, Kimbrough, Mary K, Nguyen, Jonathan, Simmons, Jon D, O'Keeffe, Terence, Crandall, Marie

“…Despite increasing usage since their introduction, there exist no evidence-based guidelines on all-terrain vehicles (ATVs) and injury prevention. While the…”
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