Search Results - "Simmons, H. A."

Age-Associated Pathology in Rhesus Macaques (Macaca mulatta) by Simmons, H. A.

“…The rhesus macaque (Macaca mulatta) is one of the most extensively used nonhuman primate models for human diseases. This article presents a literature review…”
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FDA guidelines and animal models for osteoporosis by THOMPSON, D. D, SIMMONS, H. A, PIRIE, C. M, KE, H. Z

“…The recent FDA Guidelines For Preclinical and Clinical Evaluation of Agents Used in the Treatment or Prevention of Postmenopausal Osteoporosis (1994) delineate…”
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Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice by Li, M., Healy, D.R., Li, Y., Simmons, H.A., Crawford, D.T., Ke, H.Z., Pan, L.C., Brown, T.A., Thompson, D.D.

“…The EP4 receptor, one of the subtypes of the prostaglandin E 2 (PGE 2) receptor, plays a critical role in the anabolic effects of PGE 2 on bone. However, its…”
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Evaluation of risks of viral transmission to recipients of bovine embryos arising from fertilisation with virus-infected semen by Wrathall, A.E., Simmons, H.A., Van Soom, A.

“…This scientific review was prompted by recent legislation to curtail the use of semen from potentially virus-infected bulls to produce embryos for import into…”
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Molecular Orientation and Two-Component Nature of the Crystalline Fraction of Spider Dragline Silk by Simmons, Alexandra H., Michal, Carl A., Jelinski, Lynn W.

“…The molecular origin of the exceptional mechanical properties of spider silk is unclear. This paper presents solid-state $^2$H nuclear magnetic resonance data…”
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Surface-specific effects of a PPARγ agonist, darglitazone, on bone in mice by Li, M., Pan, L.C., Simmons, H.A., Li, Y., Healy, D.R., Robinson, B.S., Ke, H.Z., Brown, T.A.

“…It has been hypothesized that activation of peroxisome-proliferator-activated receptor-γ (PPARγ) by thiazolidinedione drugs can increase adipogenesis at the…”
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Clinical and Pathologic Features of West Nile Virus Infection in Native North American Owls (Family Strigidae) by Fitzgerald, S. D, Patterson, J. S, Kiupel, M, Simmons, H. A, Grimes, S. D, Sarver, C. F, Fulton, R. M, Steficek, B. A, Cooley, T. M, Massey, J. P, Sikarskie, J. G

“…Since the initial report of West Nile virus in the northeastern United States in 1999, the virus has spread rapidly westward and southward across the country…”
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Comparative effects of droloxifene, tamoxifen, and estrogen on bone, serum cholesterol, and uterine histology in the ovariectomized rat model by Ke, H.Z., Chen, H.K., Simmons, H.A., Qi, H., Crawford, D.T., Pirie, C.M., Chidsey-Frink, K.L., Ma, Y.F., Jee, W.S.S., Thompson, D.D.

“…The purpose of this study was to compare the effects of droloxifene (DRO), tamoxifen (TAM), and 17α-ethynyl estradiol (EE) on bone mineral density, bone…”
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West Nile Virus Infection in Eastern Fox Squirrels (Sciurus niger) by Kiupel, M., Simmons, H. A., Fitzgerald, S. D., Wise, A., Sikarskie, J. G., Cooley, T. M., Hollamby, S. R., Maes, R.

“…Since the initial outbreak of West Nile virus (WNV) in the northeastern United States in 1999, the virus has rapidly spread westward and southward across the…”
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Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia by Ke, H.Z, Shen, V.W, Qi, H, Crawford, D.T, Wu, D.D, Liang, X.G, Chidsey-Frink, K.L, Pirie, C.M, Simmons, H.A, Thompson, D.D

“…It is well documented that prostaglandin E2 (PGE2) has the ability to stimulate bone formation, improve bone structure, and increase bone mass in intact or…”
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Effects of droloxifene on prevention of cancellous bone loss and bone turnover in the axial skeleton of aged, ovariectomized rats by KE, H. Z, CHEN, H. K, QI, H, PIRIE, C. M, SIMMONS, H. A, MA, Y. F, JEE, W. S. S, THOMPSON, D. D

“…The purpose of this study was to determine the efficacy of droloxifene (DRO), an estrogen antagonist/agonist, in preventing ovariectomy (OVX)-induced lumbar…”
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Parathyroid hormone (1-34) increased total body bone mass in aged female rats by Simmons, H A, Pirie, C M, Thompson, D D, Ke, H Z

“…Daily subcutaneous administration of bovine parathyroid hormone (PTH)(1-34) stimulates bone formation and increases bone mass in rat tibiae, femora and lumbar…”
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Meeting Report: Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies by Sasseville, V. G., Mansfield, K. G., Mankowski, J. L., Tremblay, C., Terio, K. A., Mätz-Rensing, K., Gruber-Dujardin, E., Delaney, M. A., Schmidt, L. D., Liu, D., Markovits, J. E., Owston, M., Harbison, C., Shanmukhappa, S., Miller, A. D., Kaliyaperumal, S., Assaf, B. T., Kattenhorn, L., Macri, S. Cummings, Simmons, H. A., Baldessari, A., Sharma, P., Courtney, C., Bradley, A., Cline, J. M., Reindel, J. F., Hutto, D. L., Montali, R. J., Lowenstine, L. J.

“…The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly…”
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Risks of transmitting ruminant spongiform encephalopathies (prion diseases) by semen and embryo transfer techniques by Wrathall, A.E., Holyoak, G.R., Parsonson, I.M., Simmons, H.A.

“…Early experiments suggested that scrapie transmission via sheep embryos was a possibility, and gave rise to much controversy. However, when account is taken of…”
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Effects of acid and basic fibroblast growth factor and heparin on resorption of cultured fetal rat long bones by Simmons, Hollis A., Raisz, Lawrence G.

“…We tested acid and basic fibroblast growth factor (aFGF and bFGF), members of the heparin binding FGF family, for their ability to stimulate bone resorption as…”
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Parathyroid Hormone-Related Protein of Malignancy: Active Synthetic Fragments by Kemp, Bruce E., Moseley, Jane M., Rodda, Christine P., Ebeling, Peter R., Richard E. H. Wettenhall, Stapleton, David, Diefenbach-Jagger, Hannelore, Ure, Fiona, Michelangeli, Valdo P., Simmons, Hollis A., Raisz, Lawrence G., Martin, T. John

“…Peptides corresponding to the amino-terminal region of the parathyroid hormone-related protein (PTHrP) of humoral hypercalcemia of malignancy were synthesized…”
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Droloxifene does not blunt bone anabolic effects of prostaglandin E2, but maintains prostaglandin E2-restored bone in aged, ovariectomized rats by KE, H. Z, CRAWFORD, D. T, QI, H, PIRIE, C. M, SIMMONS, H. A, CHIDSEY-FRINK, K. L, CHEN, H. K, JEE, W. S. S, THOMPSON, D. D

“…Droloxifene (DRO) is a selective estrogen receptor modulator that prevents bone loss by inhibition of bone turnover associated with estrogen deficiency in both…”
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The bisphosphonate, alendronate, prevents bone loss in ovariectomized baboons by Thompson, D.D., Seedor, J.G., Quartuccio, H., Solomon, H., Fioravanti, C., Davidson, J., Klein, H., Jackson, R., Clair, J., Frankenfield, D., Brown, E., Simmons, H.A., Rodan, G.A.

“…We examined the effect of the amino bisphosphonate alendronate, administered IV every 2 weeks at 0.05 and 0.25 mg/kg for 1 year, on bone loss and parameters…”
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Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats by CHEN, H. K, KE, H. Z, LIN, C. H, MA, Y. F, QI, H, CRAWFORD, D. T, PIRIE, C. M, SIMMONS, H. A, JEE, W. S. S, THOMPSON, D. D

“…Droloxifene (DRO), an estrogen antagonist/agonist, has been shown to possess estrogen-like effects in inhibiting bone turnover leading to cancellous bone loss…”
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Droloxifene prevents ovariectomy‐induced bone loss in tibiae and femora of aged female rats: A dual‐energy X‐ray absorptiometric and histomorphometric study by Chen, Hong Ka, Ke, Hua Zhu, Jee, Webster S. S., Ma, Yan Fei, Pirie, Christine M., Simmons, Hollis A., Thompson, David D.

“…Our previous studies indicated that droloxifene (DRO), a tissue‐specific estrogen antagonist/agonist, prevented bone loss without causing uterine hypertrophy…”
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