Search Results - "Simmons, DeNard V"
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Rethinking the network determinants of motor disability in Parkinson's disease
Published in Frontiers in synaptic neuroscience (28-06-2023)“…For roughly the last 30 years, the notion that striatal dopamine (DA) depletion was the critical determinant of network pathophysiology underlying the motor…”
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Differential expression of long-term potentiation among identified inhibitory inputs to dopamine neurons
Published in Journal of neurophysiology (01-10-2017)“…The in vivo firing pattern of ventral tegmental area (VTA) dopamine neurons is controlled by GABA afferents originating primarily from the nucleus accumbens…”
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Oscillations and Spike Entrainment [version 1; peer review: 2 approved]
Published in F1000 research (2018)“…Oscillatory input to networks, as indicated by field potentials, must entrain neuronal firing to be a causal agent in brain activity. Even when the oscillatory…”
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Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells
Published in Stem cells translational medicine (01-09-2016)“…: The progressive death of dopamine producing neurons in the substantia nigra pars compacta is the principal cause of symptoms of Parkinson's disease (PD)…”
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Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease
Published in Current opinion in neurobiology (01-12-2023)“…The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia is responsible for the cardinal motor symptoms of Parkinson's disease…”
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Indirect pathway control of firing rate and pattern in the substantia nigra pars reticulata
Published in Journal of neurophysiology (01-02-2020)“…Unitary pallido-nigral synaptic currents were measured using optogenetic stimulation, which activated up to three unitary synaptic inputs to each substantia…”
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