Search Results - "Simmons, David L"

Targeting kinases: a new approach to treating inflammatory rheumatic diseases by Simmons, David L

“…Highlights ► First oral kinase inhibitor drug approved by FDA for rheumatoid disease. ► Intense activity to expand the utility of JAK inhibitors in other…”
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Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells by Adams, Susan, van der Laan, Luc J. W, Vernon-Wilson, Elizabeth, Renardel de Lavalette, Chantal, Dopp, Ed A, Dijkstra, Christine D, Simmons, David L, van den Berg, Timo K

“…Signal-regulatory proteins (SIRP) are transmembrane glycoproteins with three extracellular Ig-like domains, closely related to Ag receptors Ig, TCR, and MHC,…”
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What makes a good anti-inflammatory drug target? by Simmons, David L.

“…The recent, rapid increase in the number of defined targets in the immune system will ensure a rich stream of future anti-inflammatory drug targets. This…”
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Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes by Fawcett, Jonathan, Holness, Claire L. L, Needham, Lindsey A, Turley, Helen, Gattert, Kevin C, Mason, David Y, Simmons, David L

“…The co-ordinated function of effector and accessory cells in the immune system is assisted by adhesion molecules on the cell surface that stabilize…”
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Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis by Marusic, Suzana, Leach, Michael W, Pelker, Jeffrey W, Azoitei, Mihai L, Uozumi, Naonori, Cui, Junqing, Shen, Marina W H, DeClercq, Charlene M, Miyashiro, Joy S, Carito, Brenda A, Thakker, Paresh, Simmons, David L, Leonard, John P, Shimizu, Takao, Clark, James D

“…Experimental autoimmune encephalomyelitis (EAE), a Th1-mediated inflammatory disease of the central nervous system (CNS), is a model of human multiple…”
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Anti-adhesion therapies by Simmons, David L

“…Cell adhesion molecules are key mediators of inflammatory processes and are attractive targets for discovery of novel therapeutics. There have been significant…”
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Human CD14 mediates recognition and phagocytosis of apoptotic cells by Gregory, Christopher D, Devitt, Andrew, Moffatt, Odette D, Raykundalia, Chandra, Capra, J. Donald, Simmons, David L

“…Cells undergoing programmed cell death (apoptosis) are cleared rapidly in vivo by phagocytes without inducing inflammation. Here we show that the…”
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Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways by Filer, Andrew, Bik, Magdalena, Parsonage, Greg N., Fitton, John, Trebilcock, Emily, Howlett, Katherine, Cook, Michelle, Raza, Karim, Simmons, David L., Thomas, Andrew M. C., Salmon, Mike, Scheel‐Toellner, Dagmar, Lord, Janet M., Rabinovich, Gabriel A., Buckley, Christopher D.

“…Objective High expression of galectin 3 at sites of joint destruction in rheumatoid arthritis (RA) suggests that galectin 3 plays a role in RA pathogenesis…”
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The Myeloid-specific Sialic Acid-binding Receptor, CD33, Associates with the Protein-tyrosine Phosphatases, SHP-1 and SHP-2 by Taylor, V C, Buckley, C D, Douglas, M, Cody, A J, Simmons, D L, Freeman, S D

“…The myeloid restricted membrane glycoprotein, CD33, is a member of the recently characterized “sialic acid-binding immunoglobulin-related lectin” family…”
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Macrophage Recognition of ICAM-3 on Apoptotic Leukocytes by Moffatt, Odette D, Devitt, Andrew, Bell, Elaine D, Simmons, David L, Gregory, Christopher D

“…Cells undergoing apoptosis are cleared rapidly by phagocytes, thus preventing tissue damage caused by loss of plasma membrane integrity. In this study, we show…”
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RGD peptides induce apoptosis by direct caspase-3 activation by BUCKLEY, C. D, PILLING, D, HENRIQUEZ, N. V, PARSONAGE, G, THREIFALI, K, SCHEEL-TOELLNER, D, SIMMONS, D. L, AKBAR, A. N, LORD, J. M, SALMON, M

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Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31 by Newton, Justin P., Buckley, Christopher D., Jones, E. Yvonne, Simmons, David L.

“…CD31 (PECAM-1) is a member of the immunoglobulin superfamily whose extracellular domain is comprised of six immunoglobulin-like domains. It is widely expressed…”
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Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms by FOX, S. B, FAWCETT, J, JACKSON, D. G, COLLINS, I, GATTER, K. C, HARRIS, A. L, GEARING, A, SIMMONS, D. L

“…At least 20 different isoforms of the human CD44 lymphocyte-homing receptor/hyaluronan receptor have been described to date that arise from the differential…”
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Some new, and not so new, anti-inflammatory targets by Simmons, David L, Buckley, Christopher D

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In search of an enzyme: the β-secretase of Alzheimer's disease is an aspartic proteinase by Howlett, David R., Simmons, David L., Dingwall, Colin, Christie, Gary

“…The deposition of beta-amyloid (Aβ) in the brain is a neuropathological feature of Alzheimer's disease. Aβ is cleaved from its precursor protein (APP) by…”
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Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin by MORGAN, S. M, SAMULOWITZ, U, DARLEY, L, SIMMONS, D. L, VESTWEBER, D

“…We have generated rat monoclonal antibodies (MoAbs) against cell surface antigens of the mouse endothelioma cell line bEND.3. Three antibodies (V.1A7, V.5C7,…”
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Extracellular matrix-mediated chemotaxis can impede cell migration by Perumpanani, Abbey J., Simmons, David L., Gearing, Andrew J. H., Miller, Karen M., Ward, George, Norbury, John, Schneemann, Markus, Sherratt, Jonathan A.

“…Cells use a combination of changes in adhesion, proteolysis and motility (directed and random) during the process of migration. Proteolysis of the…”
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Intercellular adhesion molecule-3 is the predominant co-stimulatory ligand for leukocyte function antigen-1 on human blood dendritic cells by Starling, G C, McLellan, A D, Egner, W, Sorg, R V, Fawcett, J, Simmons, D L, Hart, D N

“…Dendritic cells (DC) are potent stimulators of primary T lymphocyte responses to foreign antigen. The initial DC-T lymphocyte interaction involves the binding…”
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Structural motifs for recognition and adhesion in members of the immunoglobulin superfamily by HOLNESS, C. L, SIMMONS, D. L

“…ABSTRACT The immunoglobulin superfamily is the most abundant family of cell surface molecules, accounting for 50% of leukocyte surface glycoproteins. This…”
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Analysis of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated Antigen 1 (∗) by Holness, Claire L., Bates, Paul A., Littler, Amanda J., Buckley, Christopher D., McDowall, Alison, Bossy, David, Hogg, Nancy, Simmons, David L.

“…Intercellular adhesion molecule 3 (ICAM-3, CD50) is a member of the immunoglobulin superfamily and is a constitutively expressed ligand for the leukocyte…”
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