Search Results - "Simmonds, R E"

Signalling, inflammation and arthritis: NF- Kappa B and its relevance to arthritis and inflammation by Simmonds, R E, Foxwell, B M

“…In the synovial cells of patients with RA, activation of the nuclear factor- Kappa B (NF- Kappa B) pathway results in the transactivation of a multitude of…”
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TLR Signalling and Adapter Utilization in Primary Human In vitro Differentiated Adipocytes by Brenner, C., Simmonds, R. E., Wood, S., Rose, V., Feldmann, M., Turner, J.

“…Toll‐like receptors (TLRs) are central to innate immunity and yet their expression is widespread and not restricted to professional inflammatory cells. TLRs…”
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The endothelial cell protein C receptor: a candidate genetic risk factor for thrombosis by Simmonds, R E, Lane, D A

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Haemostatic genetic risk factors in arterial thrombosis by Simmonds, R E, Hermida, J, Rezende, S M, Lane, D A

“…Haemostasis plays an integral role in arterial thrombotic disease. However, establishing which of the factors are risk factors has proven surprisingly…”
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Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect by SIMMONDS, R. E, IRELAND, H, LANE, D. A, ZÖLLER, B, GARCIA DE FRUTOS, P, DAHLBÄCK, B

“…Protein S is an important regulatory protein of the coagulation cascade. The risk for venous thrombosis associated with protein S deficiency has been uncertain…”
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Genetic and Phenotypic Analysis of a Large (122-Member) Protein S–Deficient Kindred Provides an Explanation for the Familial Coexistence of Type I and Type III Plasma Phenotypes by Simmonds, Rachel E., Zöller, Bengt, Ireland, Helen, Thompson, Elizabeth, Garcı́a de Frutos, Pablo, Dahlbäck, Björn, Lane, David A.

“…Protein S deficiency is a known risk factor for thrombosis. The coexistence of phenotypic type I (reduction in total and free antigen) and type III (reduction…”
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Efficient isolation of peptide ligands for the endothelial cell protein C receptor (EPCR) using candidate receptor phage display biopanning by White, Stephen J., Simmonds, Rachel E., Lane, David A., Baker, Andrew H.

“…Phage display biopanning has been used for a number of applications including ligand generation for targeted drug delivery, targeting gene therapy vectors and…”
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Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis by SIMMONDS, R. E, IRELAND, H, KUNZ, G, LANE, D. A

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Signalling, inflammation and arthritis by Simmonds, R. E., Foxwell, B. M.

“…In the synovial cells of patients with RA, activation of the nuclear factor-κB (NF-κB) pathway results in the transactivation of a multitude of responsive…”
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NF-κB and its relevance to arthritis and inflammation by SIMMONDS, R. E, FOXWELL, B. M

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Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis. Protein S Study Group by Simmonds, R E, Ireland, H, Kunz, G, Lane, D A

“…Protein S is a protein C-dependent and independent inhibitor of the coagulation cascade. Deficiency of protein S is an established risk factor for venous…”
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Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene : Comparison with the structure of CD1/major histocompatibility complex α1 and α2 domains by SIMMONDS, R. E, LANE, D. A

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Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S–C4b binding protein complex by Rezende, Suely Meireles, Simmonds, Rachel Elizabeth, Lane, David Anthony

“…Protein S (PS) has an established role as an important cofactor to activated protein C (APC) in the degradation of coagulation cofactors Va and VIIIa. This…”
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Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation by Simmonds, R E, Foxwell, B M

“…In the synovial cells of patients with RA, activation of the nuclear factor-kappaB (NF-kappaB) pathway results in the transactivation of a multitude of…”
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Signalling, inflammation and arthritis: NF- B and its relevance to arthritis and inflammation by Simmonds, R. E., Foxwell, B. M.

“…In the synovial cells of patients with RA, activation of the nuclear factor-κB (NF-κB) pathway results in the transactivation of a multitude of responsive…”
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Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains by Simmonds, R E, Lane, D A

“…The endothelial cell protein C/activated protein C receptor (EPCR) is located primarily on the surface of the large vessels of the vasculature. In vitro…”
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Nocturnal haemodialysis: An Australian cost comparison with conventional satellite haemodialysis (Review Article) by AGAR, JOHN WM, KNIGHT, RICHARD J, SIMMONDS, ROSEMARY E, BODDINGTON, JANEANE M, WALDRON, CLAIRE M, SOMERVILLE, CHRISTINE A

“…Dialysis is an expensive therapy, particularly considering its recurrent, protracted nature while patient numbers are also increasing. To afford dialysis for…”
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Molecular diversity and thrombotic risk in protein S deficiency: The PROSIT study by Biguzzi, Eugenia, Razzari, Cristina, Lane, David A., Castaman, Giancarlo, Cappellari, Antonio, Bucciarelli, Paolo, Fontana, Gessica, Margaglione, Maurizio, D'Andrea, Giovanna, Simmonds, Rachel E., Rezende, Suely M., Preston, Roger, Prisco, Domenico, Faioni, Elena M.

“…The Protein S Italian Team (PROSIT) enrolled 79 protein S (PS) deficient families and found 38 PROS1 variations (19 novel) in 53 probands. Of these, 23…”
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Protein S Gla-domain mutations causing impaired Ca2+-induced phospholipid binding and severe functional protein S deficiency by Rezende, Suely M., Lane, David A., Mille-Baker, Blandine, Samama, Michel M., Conard, Jacqueline, Simmonds, Rachel E.

“…We have identified 2 PROS1 missense mutations in the exon that encodes the vitamin K–dependent Gla domain of protein S (Gly11Asp and Thr37Met) in kindred with…”
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Genetic and phenotypic variability between families with hereditary protein S deficiency by Rezende, Suely M, Lane, David A, Zöller, Bengt, Mille-Baker, Blandine, Laffan, Mike, Dahlbäck, Björn, Simmonds, Rachel E

“…While many mutations thought to result in protein S (PS) deficiency are known, there have been few attempts to relate genotype expression with plasma…”
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