Search Results - "Simmonds, Michael"

Endothelial inflammation: how many bad apples? by Simmonds, Michael J.

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Modulation of red blood cell nitric oxide synthase phosphorylation in the quiescent and exercising human forearm by Leo, Jeffrey A, Sabapathy, Surendran, Kuck, Lennart, Simmonds, Michael J

“…In vitro investigations demonstrate that human erythrocytes synthesize nitric oxide via a functional isoform of endothelial nitric oxide synthase (NOS)…”
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Calcium dynamically alters erythrocyte mechanical response to shear by Kuck, Lennart, Peart, Jason N., Simmonds, Michael J.

“…Red blood cells (RBC) are constantly exposed to varying mechanical forces while traversing the cardiovascular system. Upon exposure to mechanical stimuli…”
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Nitric oxide, vasodilation and the red blood cell by Simmonds, Michael J, Detterich, Jon A, Connes, Philippe

“…Since the identification of the elusive endothelium-derived relaxing factor as nitric oxide (NO), much attention has been devoted to understanding its…”
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Blood Rheology and Hemodynamics: Still Illuminating after 20 Years by Simmonds, Michael J, Meiselman, Herbert J, Detterich, Jon A

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Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal by Kuck, Lennart, McNamee, Antony P, Bordukova, Maria, Sadafi, Ario, Marr, Carsten, Peart, Jason N, Simmonds, Michael J

“…Hematopoietic stem cells surrender organelles during differentiation, leaving mature red blood cells (RBC) devoid of transcriptional machinery and…”
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The Respiratory Compensation Point is Not a Valid Surrogate for Critical Power by LEO, JEFFREY A, SABAPATHY, SURENDRAN, SIMMONDS, MICHAEL J, CROSS, TROY J

“…PURPOSEIt is unclear whether the respiratory compensation point (RCP) may be used as a valid surrogate for critical power (CP). Accordingly, we sought to…”
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Red Blood Cell Sublethal Damage: Hemocompatibility Is not the Absence of Hemolysis by McNamee, Antony P., Simmonds, Michael J.

“…•Mechanical support may cause “sublethal” injury to vital blood constituents.•Complications and premature mortality may be induced by this sublethal…”
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Impact of small fractions of abnormal erythrocytes on blood rheology by Kuck, Lennart, McNamee, Antony P., Simmonds, Michael J.

“…Red blood cell (RBC) populations are inherently heterogeneous, given mature RBC lack the transcriptional machinery to re-synthesize proteins affected during in…”
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Sublethal Supraphysiological Shear Stress Alters Erythrocyte Dynamics in Subsequent Low-Shear Flows by McNamee, Antony P., Fitzpatrick, Tom, Tansley, Geoff D., Simmonds, Michael J.

“…Blood is a non-Newtonian, shear-thinning fluid owing to the physical properties and behaviors of red blood cells (RBCs). Under increased shear flow,…”
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Repetitive Supra‐Physiological Shear Stress Impairs Red Blood Cell Deformability and Induces Hemolysis by Horobin, Jarod T., Sabapathy, Surendran, Simmonds, Michael J.

“…The supra‐physiological shear stress that blood is exposed to while traversing mechanical circulatory assist devices affects the physical properties of red…”
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Shear‐thinning behaviour of blood in response to active hyperaemia: Implications for the assessment of arterial shear stress‐mediated dilatation by Leo, Jeffrey A., Simmonds, Michael J., Sabapathy, Surendran

“…New Findings What is the central question of this study? Quantitative values of shear rate‐specific blood viscosity and shear stress in the human…”
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Exercise-induced blood lactate increase does not change red blood cell deformability in cyclists by Simmonds, Michael J, Connes, Philippe, Sabapathy, Surendran

“…The effect of exercise-induced lactate production on red blood cell deformability and other blood rheological changes is controversial, given heavy-exercise…”
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Physical Properties of Blood and their Relationship to Clinical Conditions by Alexy, Tamas, Detterich, Jon, Connes, Philippe, Toth, Kalman, Nader, Elie, Kenyeres, Peter, Arriola-Montenegro, Jose, Ulker, Pinar, Simmonds, Michael J.

“…It has been long known that blood health heavily influences optimal physiological function. Abnormalities affecting the physical properties of blood have been…”
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Reduced blood oxygen levels induce changes in low-threshold motor unit firing that align with the individual's tolerance to hypoxia by McKeown, Daniel J, Simmonds, Michael J, Kavanagh, Justin J

“…This study aimed to quantify how acute hypoxia impacts firing characteristics of biceps brachii motor units (MUs) during sustained isometric elbow flexions. MU…”
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Red blood cell tolerance to shear stress above and below the subhemolytic threshold by Horobin, Jarod T., Sabapathy, Surendran, Simmonds, Michael J.

“…Mechanical circulatory support device (MCS) design has improved over the years and yet blood damage (e.g., hemolysis) remains a problem. Accumulating evidence…”
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A Cross-Sectional Pilot Study to Examine the Criterion Validity of the Modified Shuttle Test-Paeds as a Measure of Cardiorespiratory Fitness in Children by Milne, Nikki, Simmonds, Michael J, Hing, Wayne

“…With accumulating evidence that exercise capacity decreases all-cause mortality independent of adiposity, benefits may be gained by developing…”
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Climate and vegetation dynamics of the Northern Apennines (Italy) during the Late Pleistocene and Holocene by Guido, Maria Angela, Molinari, Chiara, Moneta, Valentina, Branch, Nicholas, Black, Stuart, Simmonds, Michael, Stastney, Philip, Montanari, Carlo

“…This study reconstructs the regional vegetation and climate dynamics between the upper Late Pleistocene and Holocene around Pian del Lago, a coastal mountain…”
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Sublethal mechanical shear stress increases the elastic shear modulus of red blood cells but does not change capillary transit velocity by McNamee, Antony P., Tansley, Geoff D., Simmonds, Michael J.

“…Blood exposure to supraphysiological shear stress within mechanical circulatory support is suspected of reducing red blood cell (RBC) deformability and being…”
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Post‐fatigue ability to activate muscle is compromised across a wide range of torques during acute hypoxic exposure by McKeown, Daniel J., McNeil, Chris J., Simmonds, Michael J., Kavanagh, Justin J.

“…The purpose of this study was to assess how severe acute hypoxia alters the neural mechanisms of muscle activation across a wide range of torque output in a…”
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