Search Results - "Simmonds, Andrea C"

BIOACTIVATION OF 1,1-DICHLOROETHYLENE TO ITS EPOXIDE BY CYP2E1 AND CYP2F ENZYMES by SIMMONDS, Andrea C, REILLY, Christopher A, BALDWIN, R. Michael, GHANAYEM, Burhan I, LANZA, Diane L, YOST, Garold S, COLLINS, Kathy S, FORKERT, Poh-Gek

“…1,1-Dichloroethylene (DCE) exposure to mice elicits lung toxicity that selectively targets bronchiolar Clara cells. The toxicity is mediated by DCE metabolites…”
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Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung by Simmonds, Andrea C, Ghanayem, Burhan I, Sharma, Ashish, Reilly, Christopher A, Millen, Brandie, Yost, Garold S, Forkert, Poh-Gek

“…1,1-Dichloroethylene (DCE) exposure evokes lung toxicity with selective damage to bronchiolar Clara cells. Recent in vitro studies have implicated CYP2E1 and…”
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Involvement of cytochrome P450 2F2 in bioactivation of 1,1-dichloroethylene in mouse lung by Simmonds, Andrea C

“…1,1-Dichloroethylene (DCE) elicits pneumotoxicity upon exposure. This toxicity is mediated by CYP2E1-dependent metabolism of DCE to an epoxide, which…”
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