Search Results - "Simko, B"

Ro 25-1553: a novel, long-acting vasoactive intestinal peptide agonist. Part I: In vitro and in vivo bronchodilator studies by O'Donnell, M, Garippa, R J, Rinaldi, N, Selig, W M, Simko, B, Renzetti, L, Tannu, S A, Wasserman, M A, Welton, A, Bolin, D R

“…Ro 25-1553, a cyclic peptide analog of vasoactive intestinal peptide (VIP), was designed to overcome many of the deficiencies inherent in this natural…”
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Essential fatty acids are antagonists of the leukotriene B 4 receptor by Yagaloff, K.A., Franco, L., Simko, B., Burghardt, B.

“…A series of essential fatty acids and fatty acid derivatives were evaluated for their ability to inhibit [ 3H] leukotriene B 4 (LTB 4) binding to pig…”
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Essential fatty acids are antagonists of the leukotriene B4 receptor by YAGALOFF, K. A, FRANCO, L, SIMKO, B, BURGHARDT, B

“…A series of essential fatty acids and fatty acid derivatives were evaluated for their ability to inhibit [3H] leukotriene B4 (LTB4) binding to pig neutrophil…”
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Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation by Welton, A F, O'Donnell, M, Renzetti, L, Simko, B, Tocker, J, Cashin, C, Newbold, P, Wasserman, M A

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Structure-activity studies of vasoactive intestinal peptide (VIP): cyclic disulfide analogs by Bolin, D R, Cottrell, J, Garippa, R, O'Neill, N, Simko, B, O'Donnell, M

“…Analogs of vasoactive intestinal peptide with cysteine residues incorporated at selected sites within the sequence were prepared by solid phase methods,…”
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Analogs of arachidonic acid methylated at C-7 and C-10 as inhibitors of leukotriene biosynthesis by Cohen, N, Weber, G, Banner, B L, Welton, A F, Hope, W C, Crowley, H, Anderson, W A, Simko, B A, O'Donnell, M, Coffey, J W

“…The syntheses and biological activity of (all Z)-7,7-dimethyl-5,8,11,14- eicosatetraenoic acid, (all Z)-7,7,-dimethyl-5,8,11-eicosatrienoic acid,…”
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An in vivo model for measuring antigen-induced SRS-A-mediated bronchoconstriction and plasma SRS-A levels in the guinea-pig by Anderson, W H, O'Donnell, M, Simko, B A, Welton, A F

“…1 Pharmacological modulation of antigen-induced anaphylaxis in actively sensitized guinea-pigs with intravenously administered indomethacin (10 mg/kg),…”
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beta.1-Selective adrenoceptor antagonists. 1. Synthesis and .beta.-adrenergic blocking activity of a series of binary (aryloxy)propanolamines by Kierstead, R. W, Faraone, A, Mennona, F, Mullin, J, Guthrie, R. W, Crowley, H, Simko, B, Blaber, L. C

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Regulatory role of adenosine in antigen-induced histamine release from the lung tissue of actively sensitized guinea pigs by Welton, A F, Simko, B A

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Metal ion and guanine nucleotide regulation of the inhibition of lung adenylate cyclase by adenosine analogs by Welton, A F, Simko, B A

“…Adenosine inhibits guinea-pig lung adenylate cyclase (ATP pyrophosphatelyase (cyclizing), EC 4.6.1.1) through a 'P' type regulatory site. The inhibition is of…”
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Role of cyclooxygenase products in some of the biological effects of chemically synthesized leukotrienes (B4, C4, D4, and E4) by Welton, A F, O'Donnell, M, Anderson, W, Crowley, H, Medford, A, Simko, B, Yaremko, B

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3-Phenyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]indole-2-carbonitrile, a potent inhibitor of prostaglandin synthetase and of platelet aggregation by Fahrenholtz, Kenneth E, Silverzweig, Mary Z, Germane, Nicholas, Crowley, Herman J, Simko, Beverly A, Dalton, Colin

“…A number of indoles containing the 2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl side chain have been prepared by standard methods. Alternate, novel…”
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beta 1-selective adrenoceptor antagonists. 1. Synthesis and beta-adrenergic blocking activity of a series of binary (aryloxy)propanolamines by Kierstead, R W, Faraone, A, Mennona, F, Mullin, J, Guthrie, R W, Crowley, H, Simko, B, Blaber, L C

“…A series of binary (aryloxy)propanolamines has been prepared and examined in vitro and in vivo for beta-adrenoreceptor blocking activity. These symmetrical…”
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Comparison of cyclic and linear analogs of vasoactive intestinal peptide by Bolin, D R, Cottrell, J, Garippa, R, Rinaldi, N, Senda, R, Simko, B, O'Donnell, M

“…A series of i-->i + 4 side-chain to side-chain lactam analogs of vasoactive intestinal peptide has been prepared in order to study the effect of cyclization on…”
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Structure-activity studies on the vasoactive intestinal peptide pharmacophore. 1. Analogs of tyrosine by Bolin, D R, Cottrell, J, Garippa, R, Michalewsky, J, Rinaldi, N, Simko, B, O'Donnell, M

“…From previous work, the primary functional groups, i.e. side chains, of the vasoactive intestinal peptide which are responsible for interaction with the VIP…”
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Degradation of vasoactive intestinal peptide in bronchial alveolar lavage fluid by BOLIN, D. R, COTTRELL, J, MICHALEWSKY, J, GARIPPA, R, O'NEILL, N, SIMKO, B, O'DONNELL, M

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β1-Selective adrenoceptor antagonists. I: Synthesis and β-adrenergic blocking activity of a series of binary (aryloxy) propanolamines by KIERSTEAD, R. W, FARAONE, A, MENNONA, F, MULLIN, J, GUTHRIE, R. W, CROWLEY, H, SIMKO, B, BLABER, L. C

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ENDOCARDIAL FIBROELASTOSIS IN AN INFANT DIAGNOSED INTRA VITAM by SZANTO, D, SIMKO, B

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