Search Results - "Simkins, Helen M. A."

Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines by Petersen, Troels R, Sika-Paotonu, Dianne, Knight, Deborah A, Simkins, Helen M A, Hermans, Ian F

“…Transfer of antigen between antigen-presenting cells (APCs) is potentially a physiologically relevant mechanism to spread antigen to cells with specialized…”
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The control of CD8+ T cell responses is preserved in perforin-deficient mice and released by depletion of CD4+CD25+ regulatory T cells by Ataera, Haley, Simkins, Helen M. A., Hyde, Evelyn, Yang, Jianping, Hermans, Ian F., Petersen, Troels R., Ronchese, Franca

“…Perforin expression in the host is not required for the normal regulation of perforin‐sufficient CD8+ T cell responses after dendritic cell immunization…”
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Administration of α-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo by Simkins, Helen M. A., Hyde, Evelyn, Farrand, Kathryn J., Ong, Monique L., Degli‐Esposti, Mariapia A., Hermans, Ian F., Ronchese, Franca

“…Injection of a‐GalCer into mice is followed by a TNF‐α‐dependent decrease in the number of CD8+Langerin+ DC, and decreased cross‐presentation of blood‐borne…”
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Dendritic Cells Treated with Lipopolysaccharide Up-Regulate Serine Protease Inhibitor 6 and Remain Sensitive to Killing by Cytotoxic T Lymphocytes In Vivo by Andrew, Kate A, Simkins, Helen M. A, Witzel, Sabine, Perret, Rachel, Hudson, Jenny, Hermans, Ian F, Ritchie, David S, Yang, Jianping, Ronchese, Franca

“…Ag presentation by dendritic cells (DC) in vivo is essential to the initiation of primary and secondary T cell responses. We have reported that DC presenting…”
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B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation by Barnett, Lisa G, Simkins, Helen M A, Barnett, Burton E, Korn, Lisa L, Johnson, Andy L, Wherry, E John, Wu, Gregory F, Laufer, Terri M

“…High-affinity class-switched Abs and memory B cells are products of the germinal center (GC). The CD4+ T cell help required for the development and maintenance…”
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Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort by Simkins, Helen M. A., Merriman, Marilyn E., Highton, John, Chapman, Peter T., O'Donnell, John L., Jones, Peter B. B., Gow, Peter J., McLean, Lachy, Pokorny, Violetta, Harrison, Andrew A., Merriman, Tony R.

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Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells by Korn, L L, Thomas, H L, Hubbeling, H G, Spencer, S P, Sinha, R, Simkins, H MA, Salzman, N H, Bushman, F D, Laufer, T M

“…The innate and adaptive immune systems in the intestine cooperate to maintain the integrity of the intestinal barrier and to regulate the composition of the…”
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