Search Results - "Simkó, J"

G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA by Simko, Eric A J, Liu, Honghe, Zhang, Tao, Velasquez, Adan, Teli, Shraddha, Haeusler, Aaron R, Wang, Jiou

“…Abstract The long non-coding RNA NEAT1 serves as a scaffold for the assembly of paraspeckles, membraneless nuclear organelles involved in gene regulation…”
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BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups by Berres, Marie-Luise, Lim, Karen Phaik Har, Peters, Tricia, Price, Jeremy, Takizawa, Hitoshi, Salmon, Hélène, Idoyaga, Juliana, Ruzo, Albert, Lupo, Philip J, Hicks, M John, Shih, Albert, Simko, Stephen J, Abhyankar, Harshal, Chakraborty, Rikhia, Leboeuf, Marylene, Beltrão, Monique, Lira, Sérgio A, Heym, Kenneth M, Bigley, Venetia, Collin, Matthew, Manz, Markus G, McClain, Kenneth, Merad, Miriam, Allen, Carl E

“…Langerhans cell histiocytosis (LCH) is a clonal disorder with elusive etiology, characterized by the accumulation of CD207(+) dendritic cells (DCs) in…”
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Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis by Chakraborty, Rikhia, Hampton, Oliver A., Shen, Xiaoyun, Simko, Stephen J., Shih, Albert, Abhyankar, Harshal, Lim, Karen Phaik Har, Covington, Kyle R., Trevino, Lisa, Dewal, Ninad, Muzny, Donna M., Doddapaneni, Harshavardhan, Hu, Jianhong, Wang, Linghua, Lupo, Philip J., Hicks, M. John, Bonilla, Diana L., Dwyer, Karen C., Berres, Marie-Luise, Poulikakos, Poulikos I., Merad, Miriam, McClain, Kenneth L., Wheeler, David A., Allen, Carl E., Parsons, D. Williams

“…Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207+ dendritic cells with an…”
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The Balance Sheet as an Earnings Management Constraint by Barton, Jan, Simko, Paul J.

“…The balance sheet accumulates the effects of previous accounting choices, so the level of net assets partly reflects the extent of previous earnings…”
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PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer by Crane, C A, Panner, A, Murray, J C, Wilson, S P, Xu, H, Chen, L, Simko, J P, Waldman, F M, Pieper, R O, Parsa, A T

“…Immune escape describes a critical event whereby tumor cells adopt an immunoresistant phenotype to escape adaptive surveillance. We show that expression of a…”
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Clofarabine salvage therapy in refractory multifocal histiocytic disorders, including Langerhans cell histiocytosis, juvenile xanthogranuloma and Rosai-Dorfman disease by Simko, Stephen J., Tran, Huy D., Jones, Jeremy, Bilgi, Mrinalini, Beaupin, Lynda Kwon, Coulter, Don, Garrington, Timothy, McCavit, Timothy L., Moore, Colin, Rivera-Ortegón, Francisco, Shaffer, Linda, Stork, Linda, Turcotte, Lucie, Welsh, Esperanza C., Hicks, M. John, McClain, Kenneth L., Allen, Carl E.

“…Background Existing therapies for recurrent or refractory histiocytoses, including Langerhans cell histiocytosis (LCH), juvenile xanthogranuloma (JXG), and…”
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Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3 by Chen, L, Hong, C, Chen, E C, Yee, S W, Xu, L, Almof, E U, Wen, C, Fujii, K, Johns, S J, Stryke, D, Ferrin, T E, Simko, J, Chen, X, Costello, J F, Giacomini, K M

“…Human organic cation transporter 3 ( OCT3 and SLC22A3 ) mediates the uptake of many important endogenous amines and basic drugs in a variety of tissues. OCT3…”
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Differentiating Skin-Limited and Multisystem Langerhans Cell Histiocytosis by Simko, Stephen J., MD, Garmezy, Benjamin, BA, Abhyankar, Harshal, MS, Lupo, Philip J., PhD, Chakraborty, Rikhia, PhD, Lim, Karen Phaik Har, MS, Shih, Albert, BS, Hicks, M. John, MD, PhD, DDS, Wright, Teresa S., MD, Levy, Moise L., MD, McClain, Kenneth L., MD, PhD, Allen, Carl E., MD, PhD

“…Objective To identify features associated with multisystem involvement and therapeutic failure in patients with skin Langerhans cell histiocytosis (LCH). Study…”
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Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors by Ducker, G S, Atreya, C E, Simko, J P, Hom, Y K, Matli, M R, Benes, C H, Hann, B, Nakakura, E K, Bergsland, E K, Donner, D B, Settleman, J, Shokat, K M, Warren, R S

“…The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But…”
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Morphological features of TMPRSS2-ERG gene fusion prostate cancer by Mosquera, J-M, Perner, S, Demichelis, F, Kim, R, Hofer, MD, Mertz, KD, Paris, PL, Simko, J, Collins, C, Bismar, TA, Chinnaiyan, AM, Rubin, MA

“…The TMPRSS2–ETS fusion prostate cancers comprise 50–70% of the prostate‐specific antigen (PSA)‐screened hospital‐based prostate cancers examined to date,…”
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Prognostic value of Ki67 in localized prostate carcinoma: a multi-institutional study of >1000 prostatectomies by Tretiakova, M S, Wei, W, Boyer, H D, Newcomb, L F, Hawley, S, Auman, H, Vakar-Lopez, F, McKenney, J K, Fazli, L, Simko, J, Troyer, D A, Hurtado-Coll, A, Thompson, I M, Carroll, P R, Ellis, W J, Gleave, M E, Nelson, P S, Lin, D W, True, L D, Feng, Z, Brooks, J D

“…Background: Expanding interest in and use of active surveillance for early state prostate cancer (PC) has increased need for prognostic biomarkers. Using a…”
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The impact of serum lipids on risk for microangiopathy in patients with type 2 diabetes mellitus by Toth, Peter P, Simko, Robert J, Palli, Swetha Rao, Koselleck, Dawn, Quimbo, Ralph A, Cziraky, Mark J

“…Few large-scale, real-world studies have assessed the relative associations of lipid fractions with diabetic microvascular events. The main objective of this…”
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Proarrhythmic Potential of Antimicrobial Agents by Simkó, J., Csilek, A., Karászi, J., Lőrincz, I.

“…Several antiarrhythmic and non-cardiovascular drug therapies including antimicrobial agents have been implicated as the causes for QT interval prolongation,…”
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Effects of rosiglitazone on the configuration of action potentials and ion currents in canine ventricular cells by Szentandrássy, N, Harmati, G, Bárándi, L, Simkó, J, Horváth, B, Magyar, J, Bányász, T, Lőrincz, I, Szebeni, A, Kecskeméti, V, Nánási, PP

“…BACKGROUND AND PURPOSE In spite of its widespread clinical application, there is little information on the cellular cardiac effects of the antidiabetic drug…”
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Carbamazepine and risk of hypothyroidism: a prospective study by Simko, J., Horacek, J.

“…Objectives –  While carbamazepine (CBZ) decreases thyroid hormone concentrations it rarely causes hypothyroidism. We assessed prospectively the early effect of…”
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Can the electrophysiological action of rosiglitazone explain its cardiac side effects? by Szebeni, A, Szentandrássy, N, Pacher, P, Simkó, J, Nánási, P P, Kecskeméti, V

“…Recent large clinical trials found an association between the antidiabetic drug rosiglitazone therapy and increased risk of cardiovascular adverse events. The…”
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Discretionary earnings smoothing, credit quality, and firm value by Allayannis, George, Simko, Paul J.

“…This paper examines the conditional association between earnings smoothing via discretionary accruals and firms’ credit quality and value. We argue that the…”
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Successful whole-exome sequencing from a prostate cancer bone metastasis biopsy by Van Allen, E M, Foye, A, Wagle, N, Kim, W, Carter, S L, McKenna, A, Simko, J P, Garraway, L A, Febbo, P G

“…Background: Comprehensive molecular characterization of cancer that has metastasized to bone has proved challenging, which may limit the diagnostic and…”
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Friction, Wear, and Surface Film Formation Characteristics of Diamond-Like Carbon Thin Coating in Valvetrain Application by GANGOPADHYAY, ARUP, SINHA, KAUSTAV, UY, DAIRENE, MCWATT, DOUGLAS G., ZDRODOWSKI, ROBERT J., SIMKO, STEVEN J.

“…The friction and wear characteristics of thin diamond-like carbon (DLC) coatings have been investigated extensively in recent years mostly in laboratory bench…”
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Valvetrain Friction Reduction through Thin Film Coatings and Polishing by Gangopadhyay, Arup, McWatt, Douglas G., Zdrodowski, Robert J., Simko, Steve J., Matera, Steve, Sheffer, Kirk, Furby, Robert S.

“…In a direct-acting mechanical bucket tappet-type valvetrain, the cam and tappet contact is responsible for about 85% of the total valvetrain frictional losses…”
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