Interferon gamma, interleukin 8 and interleukin 10 in serum of patients with the cervical infection and symptoms of the imminent preterm delivery

Preterm delivery (PTD), defined as a delivery between 24th and 37th completed week, increases the risk of neonatal morbidity and mortality. There is a growing body of evidence that the intrauterine infection as well as cervicovaginal bacterial infections and Chlamydia infections are possible causes...

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Published in:	Srpski arhiv za celokupno lekarstvo Vol. 141; no. 9-10; pp. 623 - 628
Main Authors:	Bogavac, Mirjana, Brkić, Snezana, Celić, Dejan, Simin, Nataja, Matijasević, Jovan, Ilić, Tatjana
Format:	Journal Article
Language:	English
Published:	Serbia Serbian Medical Society 2013
Subjects:	Adolescent Adult bacterial infection Candida Case-Control Studies Chlamydia trachomatis Female Humans Infant, Newborn interferon gamma Interferon-gamma - blood interleukin 10 interleukin 8 Interleukin-10 - blood Interleukin-8 - blood Obstetric Labor, Premature - blood Obstetric Labor, Premature - microbiology Pregnancy Pregnancy Complications, Infectious - blood Pregnancy Complications, Infectious - microbiology preterm delivery Uterine Cervical Diseases - blood Uterine Cervical Diseases - microbiology Young Adult
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Summary:	Preterm delivery (PTD), defined as a delivery between 24th and 37th completed week, increases the risk of neonatal morbidity and mortality. There is a growing body of evidence that the intrauterine infection as well as cervicovaginal bacterial infections and Chlamydia infections are possible causes of preterm delivery. Host response to cervicovaginal and/or intrauterine infections is coupled with a release of various inflammatory mediators, many of which are cytokines. The aim of the study was to find out if cervical infection influenced the serum levels of interferon-gamma (IFN-gamma), interleukin 8 (IL-8) and interleukin 10 (IL-10) in patients with the clinical symptoms of the imminent preterm delivery. A total of 128 pregnant women (from 24 to 30 weeks of gestation) with the clinical symptoms of the imminent preterm delivery were divided in: study group--85 patients with the cervical infection, and control group--43 patients without the cervical infection. The level of cytokines in the serum was measured with commercial ELISA tests. No significant difference could be found in serum levels of IFN-gamma (p = 0.632), IL-8 (p = 0.712) and IL-10 (p = 0.676) between these two investigated groups. The results of our study suggest that there is no significant difference in serum IFN-gamma, IL-8 and IL-10 concentrations between pregnant women with the symptoms of the imminent preterm delivery who had and had no cervical infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0370-8179 2406-0895
DOI:	10.2298/SARH1310623B